DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Br140 and jade3

DIOPT Version :9

Sequence 1:	NP_001286155.1	Gene:	Br140 / 35648	FlyBaseID:	FBgn0033155	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_970614.2	Gene:	jade3 / 322209	ZFINID:	ZDB-GENE-030131-928	Length:	795	Species:	Danio rerio

Alignment Length:	897	Identity:	241/897 - (26%)
Similarity:	371/897 - (41%)	Gaps:	203/897 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 RNGCSSASAGGGSAS-GVSARQY-ANPESLVSYNEEEATVTFNLDGKSVRLGIDDALPL-----V 151
            |...||.|:...|.| ..|:.:| :.|.:..|..::.|.|        .|..:..|:.|     :
Zfish     5 RTPSSSDSSDNESPSTSFSSNKYGSKPGTPASAQKKPAEV--------FRKDLISAMKLPDSHHI 61

  Fly   152 EDEEFAALVARGCILNADAPPLEENAPWAR-VQVPVARVAEI--PDYRVSDAPPRPLAY---YRF 210
            ..|::..|        ||....|    |.: ||| :|....|  |..|:....|:.:.:   .::
Zfish    62 SSEDYYLL--------ADTWKQE----WEKGVQV-LASPDTIPQPSVRIITEKPKEVLFSKPRKY 113

  Fly   211 IE-----------KSLEEL-DGEVEYDVDEEDSAWLEHMNEERQRLGLNAVGIDTMELLMDRLEK 263
            |:           .:::|| :....||:|:.|..||:.:|.|...:|...|...|||.:|:.||:
Zfish   114 IQCWSQDSTETGYVNIKELAEAMCRYDLDDMDLYWLQQLNAELGMMGDGVVDELTMERVMEALER 178

  Fly   264 ESH---FQAAANGTPTGVEVDDDAVCCICLDGECQNTNVILFCDMCNLAVHQDCYGVPYIPEGQW 325
            :.|   ..|.......|:|.|:|.:|.:|...:.:..|.::|||.||:.|||.|||:..:|:|.|
Zfish   179 QCHENMNHAIETEEGLGIEYDEDVICDVCRSPDSEEGNDMVFCDKCNICVHQACYGIVKVPDGNW 243

  Fly   326 LCRRCLQSPSKPVNCVLCPNAGGAFKQTDHG-QWAHVVCALWIPEVRFANTVFLEPIDSIETIPP 389
            |||.|:...:.  .|:|||..|||.|.|..| :||||.||||||||..|....:|||..:..|||
Zfish   244 LCRTCVLGITP--QCLLCPKTGGAMKATRAGTKWAHVSCALWIPEVSIACPERMEPITKVSHIPP 306

  Fly   390 ARWRLTCYVCKEKGLGACIQCHRNSCYAAFHVTCAQQAGLYMTMDTVKDGHNDSSMHVQKFAYCH 454
            :||.|.|.:||.| .||||||...:|...||||||.:..|  .|.|:.|..::    |:..:||.
Zfish   307 SRWSLICSLCKLK-TGACIQCSVKNCTIPFHVTCAFEHSL--EMKTILDEGDE----VKFKSYCL 364

  Fly   455 AHTPADAKLKMNVPDFEDTRHKMKEARKAL---AKKRSTAPVVLIPTIPPDRVQEIATMVTMQRK 516
            .|    :|.|...|.....|||.......|   |:|...........:.|:.|..     .:...
Zfish   365 KH----SKPKAGEPGLSPARHKPPTETDKLSLRAQKLQELEEEFYTYVHPEEVAH-----DLSLP 420

  Fly   517 KEFLDRIIAYWTLKRHYRNGVPLLRRLQSQGNNHGVIQRNGIEGSPDTGELYRQLKYWQCLRQDL 581
            ...||.|..||.:||.......||...:.:.|.  ::|       |....::.:::.:..|||||
Zfish   421 LHLLDFIFQYWKMKRKSNFNKALLPPKEDEENL--LLQ-------PQEDSIHTRMRMFMHLRQDL 476

  Fly   582 ERARLLCELVRKREKLKVAFVRISEEVVMLQLNPLEAALNKLLDALEARDSMQIFREPVDTSEVP 646
            ||.|.||.:|.:|||||::..:..|::..|.:..:...|:..|....:.::: :|..|      |
Zfish   477 ERVRNLCYMVSRREKLKLSQSKAQEQIFNLHVKLVNQELSAGLPVSSSIENL-LFHPP------P 534

  Fly   647 DYTDIVKQP-MDLGTMRAKLKE-----CQYNSLEQLEADFDLMIQNCLAYNNKDTVFYRAGIRMR 705
            ..|..:|.| :.||..::..|.     |..||              |..|:..:     .||
Zfish   535 RITLKLKMPKVQLGNGKSSSKSGNGPLCPDNS--------------CNLYDTSE-----GGI--- 577

  Fly   706 DQAAPLFVQVRKELQR--DGLLARSQRYHVD-----------------HV-------------EA 738
            .|..|.....|:.::.  :|:|..|.....|                 |.             ||
Zfish   578 GQGKPQLHLGRQRIEERINGILPASIYIRRDGGTPPLAVKQSGKPLALHAALHGQSSNGKTKNEA 642

  Fly   739 EVEQELRLLLAAPASEGIVQKLLILADKSQVLKNPTYRTKKIKQIRLEISRMRKSLQKARFAARH 803
            |..::::       |.||:.|.::..|.|.:..:.       |..|.|||  .|| |.:.|....
Zfish   643 EKTRQIK-------SNGILDKPILQRDTSCLAASE-------KDPRSEIS--GKS-QPSGFHKTS 690

  Fly   804 SSHANQS---------QSDDEDTLGGSPSKKRTRKRFNSSGVDMEL----------------GHD 843
            ..|.::|         :::|..|.     :|.:||   |||....|                |:.
Zfish   691 LEHFSRSLKEATVSLVRTEDLRTF-----EKNSRK---SSGFSKPLSTERPQGGGRASQESDGYC 747

  Fly   844 DDDEEEDSDEDSMGEDTVSKDLLNSTQTPPCSPIKSLNNSSSPVGINRRTAI 895
            .|.|..||:.::.|:....    ..||......:||.:.:....|  .||::
Zfish   748 PDAELSDSEPEAKGKCRQG----GRTQNQRGDYVKSASRAKHSYG--SRTSV 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_001286155.1	EPL1	<192..264	CDD:287484	23/88 (26%)
		PHD_BRPF	283..336	CDD:277047	22/52 (42%)
		ePHD_BRPF	340..456	CDD:277140	56/116 (48%)
		Bromo_brd1_like	615..712	CDD:99944	20/102 (20%)
		BR140_related	1303..1414	CDD:99900
jade3	NP_970614.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		10/35 (29%)
		EPL1	<89..178	CDD:287484	22/88 (25%)
		COG5141	139..555	CDD:227470	151/449 (34%)
		PHD_JADE3	203..252	CDD:277151	21/48 (44%)
		ePHD_JADE3	256..366	CDD:277176	56/116 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	630..654		5/30 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	667..687		8/29 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	714..795		20/94 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840