DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Br140 and Jade1

DIOPT Version :9

Sequence 1:	NP_001286155.1	Gene:	Br140 / 35648	FlyBaseID:	FBgn0033155	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	XP_006232363.1	Gene:	Jade1 / 310352	RGDID:	1306920	Length:	847	Species:	Rattus norvegicus

Alignment Length:	832	Identity:	220/832 - (26%)
Similarity:	349/832 - (41%)	Gaps:	194/832 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 PWAR-----VQVPVARVAEIPDYRVSDAPPRPLAYYRFIEKSL----------------EEL--- 218
            ||.:     |||||:          ....|:|:|.....||||                .||
  Rat    90 PWRQEWEKGVQVPVS----------PGTIPQPVARVVSEEKSLMFIRPKKYIASSGSEPPELGYV 144

  Fly   219 ------DGEVEYDVDEEDSAWLEHMNEERQRLGLNAVGIDTMELLMDRLEKE-----SHFQAAAN 272
                  |....||:::.|:||||..|||.:.:|:..:...|||.:::..|:.     :|......
  Rat   145 DIRTLADSVCRYDLNDMDAAWLELTNEEFKEMGMPELDEYTMERVLEEFEQRCYDNMNHAIETEE 209

  Fly   273 GTPTGVEVDDDAVCCICLDGECQNTNVILFCDMCNLAVHQDCYGVPYIPEGQWLCRRCLQSPSKP 337
            |  .|:|.|:|.||.:|...:.::.|.::|||.||:.|||.|||:..:|||.||||.|......
  Rat   210 G--LGIEYDEDVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGVQP- 271

  Fly   338 VNCVLCPNAGGAFKQTDHG-QWAHVVCALWIPEVRFANTVFLEPIDSIETIPPARWRLTCYVCKE 401
             .|:|||..|||.|.|..| :|.||.||||||||...:...:|||..:..||.:||.|.|.:|.|
  Rat   272 -KCLLCPKKGGAMKPTRSGTKWVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALVCSLCNE 335

  Fly   402 KGLGACIQCHRNSCYAAFHVTCAQQAGLYMTMDTVKDGHNDSSMHVQKFAYCHAHT--------- 457
            | .||.|||...:|..|||||||...||  .|.|:. ..||   .|:..:||..|:
  Rat   336 K-FGASIQCSVKNCRTAFHVTCAFDRGL--EMKTIL-AEND---EVKFKSYCPKHSSHRKPEESL 393

  Fly   458 ---------PADAKLKMNVPDFEDTRHKMKEARKALAKKRSTAPVVLIPTIPPDRVQEIATMVTM 513
                     ..:...:..:..|.......:||.:...:|:....:       .|.......::.:
  Rat   394 GEGAAQENGATECSPQSPLEPFASLEQNREEAHRVSVRKQKLQQL-------EDEFYTFVNLLDV 451

  Fly   514 QR----KKEFLDRIIAYWTLKRHYRNGVPLLRRLQSQGNNHGVIQRNGIEGSPDTGELYRQLKYW 574
            .|    .:|.:|.:..||.|||......||:...:.:.:|  :.:|       :...|:|:|:.:
  Rat   452 ARALRLPEEVVDFLYQYWKLKRKINFNKPLITPKKDEEDN--LAKR-------EQDVLFRRLQLF 507

  Fly   575 QCLRQDLERARLLCELVRKREKLKVAFVRISEEVVMLQLNPLE-AALNKLLDALEARDSMQIFRE 638
            ..|||||||.|.|..:|.:|||:|.:..::.|::..|....|| ..::.:..:..:.::|.:|..
  Rat   508 THLRQDLERVRNLTYMVTRREKIKRSVCKVQEQIFSLYAKLLEQGKVSGVPSSCSSLENMLLFNS 572

  Fly   639 PVDTSEVPDYTDI------VKQPMDLGTMRAKLKECQYNSLEQLEADFDLMIQNCLAYNNKDTVF 697
            |.....||...|:      .::.|....:.:..|..:.::|           ||......| |:.
  Rat   573 PSVGPNVPKIEDLKWHSAFFRKQMGTNLVHSLKKSHKRDAL-----------QNSSGTEGK-TLL 625

  Fly   698 YRAGIRMRDQAAPL----------FVQVR---KELQRDGLLA------RSQRYHVDHVEAEVEQE 743
            .:.|:..|.:.:.:          |.:.|   ...|::|::.      |..|:|.|.|:.:::.:
  Rat   626 KQPGLSGRREGSGVPESLLSFEKTFAEARLISSAQQKNGVVTPDHGKRRDNRFHCDLVKGDLKDK 690

  Fly   744 --------LRLL---------LAAPASEGIVQ------KLLILADKSQVLKNPTYRTKKIKQ--- 782
                    ||..         ..|..|.|:.|      |.::......::|.||.....:|.
  Rat   691 SFKQSHKPLRSTDTSQRHLDNTRAATSPGVGQSAPGTRKEIVPKCNGSLVKVPTTPASPVKSWGG 755

  Fly   783 IRLEISRMRKSLQKARFAARHSSHANQSQSDDEDTLGGS--PSKKRTRKRFNSSGVDMEL-GHDD 844
            .|:.....|:...:|...|.|       |..|...||.|  |:|:|::.|..:   |.|. |:..
  Rat   756 FRIPKKGERQQQGEAHDGACH-------QHSDCSHLGISRAPAKERSKSRLRT---DSENDGYAP 810

  Fly   845 DDEEEDSDEDSMGEDTVSKDLLNSTQTPPCSPIKSLNNSSSPVGINRRTAIL 896
            |.|..||:.::                   |..|.::.||:   |:|||.|:
  Rat   811 DGEMSDSESEA-------------------SEKKCIHASST---ISRRTDII 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_001286155.1	EPL1	<192..264	CDD:287484	25/96 (26%)
		PHD_BRPF	283..336	CDD:277047	24/52 (46%)
		ePHD_BRPF	340..456	CDD:277140	55/116 (47%)
		Bromo_brd1_like	615..712	CDD:99944	17/113 (15%)
		BR140_related	1303..1414	CDD:99900
Jade1	XP_006232363.1	EPL1	<107..195	CDD:287484	24/87 (28%)
		PHD_JADE1	220..265	CDD:277149	22/44 (50%)
		ePHD_JADE1	270..387	CDD:277174	56/125 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810