Protein Alignment Br140 and Jade2

DIOPT Version :10

• Sequence 1: NP_610266.1
• Gene: Br140 / 35648
• FlyBaseID: FBgn0033155
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: XP_038941852.1
• Gene: Jade2 / 303113
• RGDID: 1309152
• Length: 901
• Species: Rattus norvegicus
• Alignment Length: 1160
• Identity: 276/1160 - (23%)
• Similarity: 395/1160 - (34%)
• Gaps: 418/1160 - (36%)

  Fly    52 PQPLTP----------VLTPSRKKARSR----SGGHHSTPRPHKDHPTPGG-------GGAEARN 95
            |:|..|          :..|:...||||    ||||.....| .:|.:|.|       ||.|...
  Rat     4 PRPPAPAPGAPGFRSILPAPAPAAARSRGQRPSGGHRGARAP-GEHTSPPGPPVPSSLGGLELAE 67

  Fly    96 ---------------GCSSASAGGGSASGVSARQYAN-PESLVS----YNEEEATVTFNLDGKSV 140
                           ...::....|..:..||.:.:. |.|..|    .||::.:..|..| ...
  Rat    68 QSTKQMEEKRRKYSISSDNSDTTDGHVTSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTD-LIT 131

  Fly   141 RLGIDDALPLVEDEEFAALVARGCILNADAPPLEENAPWAR-----VQVPVARVAEIPDYRVSDA 200
            .:.|.|:..|..|:.:         :.||        ||.:     ||||....| ||:..|...
  Rat   132 AMKIPDSYQLSPDDYY---------ILAD--------PWRQEWEKGVQVPAGAEA-IPEPVVRIL 178

  Fly   201 PP-----------RPLAYYRFIEKSLEELDGEVEYDVDEEDSAWLEHMNEERQRLGLNAVGIDTM 254
            ||           .|    ...|.:..:..|...||:||.|:.|||.:|.|.:.:....:...|:
  Rat   179 PPLKGPPTLMSPESP----TLGEGAHPDWPGGSRYDLDEIDAYWLELLNSELKEMEKPELDELTL 239

  Fly   255 ELLMDRLEKESH---FQAAANGTPTGVEVDDDAVCCICLDGECQNTNVILFCDMCNLAVHQDCYG 316
            |.:::.||...|   .||.......|:|.|:|.||.:|...|.::.|.::|||.||:.|||.|||
  Rat   240 ERVLEELETLCHQNMAQAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYG 304

  Fly   317 VPYIPEGQWLCRRCLQSPSKPVNCVLCPNAGGAFKQTDHG-QWAHVVCALWIPEVRFANTVFLEP 380
            :..:|.|.||||.|......  .|:|||..|||.|.|..| :|.||.||||||||.......:||
  Rat   305 ILKVPTGSWLCRTCALGVQP--KCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEP 367

  Fly   381 IDSIETIPPARWRLTCYVCKEKGLGACIQCHRNSCYAAFHVTCAQQAGLYMTMDTVKDGHNDSSM 445
            |..|..||.:||.|:|.:||| ..|.||||...||..|||||||...||  .|.|:. ..||
  Rat   368 ITKISHIPASRWALSCSLCKE-CTGTCIQCSTPSCLTAFHVTCAFDRGL--EMRTIL-ADND--- 425

  Fly   446 HVQKFAYCHAHTPADAKLKMNVPDFEDTRHKMKEARKALAKKRSTAPVV--LIPTIPPDRVQEIA 508
            .|:..:.|..|:....:.:.:....|.:: .:::..|...:|:....:.  ....:.|..|.|
  Rat   426 EVKFKSLCQEHSDGGPRSEPSSEPVEPSQ-AVEDLEKVTLRKQRLQQLEENFYELVEPAEVAE-- 487

  Fly   509 TMVTMQRKKEFLDRIIAYWTLKRHYRNGVPLLRRLQSQGNNHGVIQRNGIEGSPDTGE------- 566
               .:...:..:|.|..||.|||......|||                    :|.|.|
  Rat   488 ---RLDLAEALVDFIYQYWKLKRRANANQPLL--------------------TPKTDEVDNLAQQ 529

  Fly   567 ----LYRQLKYWQCLRQDLERARLLCELVRKREKLKVAFVRISEEVVMLQLNPLEAALNKLLDAL 627
                |||:||.:..|||||||.|.||.:|.:||:.|....::.|::..||:
  Rat   530 EQDVLYRRLKLFTHLRQDLERVRNLCYMVTRRERTKHTICKLQEQIFHLQM-------------- 580

  Fly   628 EARDSMQIFREPVDTSEVPDYTDIVKQPMDLGTMRAKLKECQYNSLEQLEADFDLMIQNCLAYNN 692
                                                ||
  Rat   581 ------------------------------------KL--------------------------- 582

  Fly   693 KDTVFYRAGIRMRDQAAPLFVQVRKELQRDGLLARSQRYHVDHVEAEVEQELRLLLAAPASEGIV 757
                                                           :||:|
  Rat   583 -----------------------------------------------IEQDL------------- 587

  Fly   758 QKLLILADKSQVLKNPTYRTKKIKQIRLEISRMRKSLQKARFAARHSSHANQSQSDDEDTLGGSP 822
                        .:.|:.|..|.|:        ..|.:|.|                |...|.||
  Rat   588 ------------CREPSGRRSKGKK--------NDSKRKGR----------------EGPKGSSP 616

  Fly   823 SKKRTRKR---------------------FNS--------SGVDMEL-------GHDDD------ 845
            .||...|.                     |||        :..||.:       ||.:|
  Rat   617 EKKEKMKAGPESVLGQLGLSTSFPIDGTFFNSWLAQSVQITAEDMAMSEWSLNSGHREDPAPGLL 681

  Fly   846 DEEEDSDEDSMGEDTVSKDLLNSTQTPPCSPIKSLNNSSSPVGINRRTAILLTRKAQAALKRPSE 910
            .||...||::         ||:..:.|...|       ..|           .|||:...:.|::
  Rat   682 SEELLQDEET---------LLSFMRDPSLRP-------GDP-----------ARKARGRTRLPAK 719

  Fly   911 PLTTPVKEEQHNSQSSNTQSTSGSSSSVTTAATA----ASSGAGTLNHVLSSAPPTASSFALTQN 971
            ....|:::              |.|:..|....|    |..|.||.... :..||..:|..|..:
  Rat   720 KKPPPLQD--------------GPSARTTPEKPAKKAWAQDGKGTQGPP-ARKPPRRTSSHLPSS 769

  Fly   972 NSSGGGALASGTGIGGSSSAGTAAAASLTSTALAMNSKLSANL--PVKSPKRPGRYRRVPEVRHS 1034
            .::|...:.:..     .|..|.|:..|..|..|. |.|:..:  |..|||..||.|...|::.|
  Rat   770 PAAGDCPVPATL-----ESPPTLASEILDETVPAA-SDLNVQVPGPTVSPKPLGRLRPPREMKVS 828

  Fly  1035 SSMSPKKSPNPAVTVSQALP-----MPE-TLPFERIPDSFRVYRANNQRDVSDSD 1083
                 :|||.........||     .|: :|.|:...|.:     .:..::||||
  Rat   829 -----RKSPGARSDAGTGLPSTVAERPKVSLHFDTEADGY-----FSDEEMSDSD 873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_610266.1	SFP1	<22..61	CDD:227516	3/18 (17%)
		COG5141	203..>625	CDD:227470	145/438 (33%)
		Bromo_brd1_like	615..712	CDD:99944	2/96 (2%)
		MSCRAMM_ClfA	<1080..1163	CDD:468110	4/4 (100%)
		PWWP_BRPF	1303..1414	CDD:438964
Jade2	XP_038941852.1	COG5141	209..>578	CDD:227470	140/403 (35%)
		PHD_SF	326..436	CDD:473978	56/116 (48%)
		PHA03247	<676..852	CDD:223021	50/228 (22%)