DRSC/TRiP Functional Genomics Resources

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Protein Alignment Br140 and BRPF3

DIOPT Version :9

Sequence 1:NP_001286155.1 Gene:Br140 / 35648 FlyBaseID:FBgn0033155 Length:1430 Species:Drosophila melanogaster
Sequence 2:NP_056510.2 Gene:BRPF3 / 27154 HGNCID:14256 Length:1205 Species:Homo sapiens


Alignment Length:1488 Identity:490/1488 - (32%)
Similarity:699/1488 - (46%) Gaps:420/1488 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 RKKARSRSGGHHSTPRPH--KDHPTPGGGGAEARNGCSSASAGGGSASGVSARQYANPESLVSYN 125
            |:|:|..:.|..| |.|:  |..||                                 ...::|.
Human     5 RRKSRQNAEGRRS-PSPYSLKCSPT---------------------------------RETLTYA 35

  Fly   126 EEEATVTFNLDGKSVRLGIDDALPLVEDEEFAALVARGCIL---NADAPPL-------------- 173
            :.:..|..::||:..|:.|.|.|.::.::|..|.....|..   |::.|..              
Human    36 QAQRIVEVDIDGRLHRISIYDPLKIITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKK 100

  Fly   174 ---EENAPWARVQVPVARVAEIPDYRVSD------APPRPLAYYRFIEKSLEELDGEVEYDVDEE 229
               .::|......:|.      |.:|:.|      |||.|.||||:|||..|:||.|||||:|||
Human   101 ESCSKHASGTSFHLPQ------PSFRMVDSGIQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEE 159

  Fly   230 DSAWLEHMNEERQRLGLNAVGIDTMELLMDRLEKESHFQAAANGTPTGVEVDDDAVCCICLDGEC 294
            |.|||:.:||:|:..|.:.|..||.|||:|||||||:.::.::|....: :|:||.||:|||.||
Human   160 DLAWLDMVNEKRRVDGHSLVSADTFELLVDRLEKESYLESRSSGAQQSL-IDEDAFCCVCLDDEC 223

  Fly   295 QNTNVILFCDMCNLAVHQDCYGVPYIPEGQWLCRRCLQSPSKPVNCVLCPNAGGAFKQTDHGQWA 359
            .|:|||||||:|||||||:|||||||||||||||.||||||:||:|:||||.|||||||..|.||
Human   224 HNSNVILFCDICNLAVHQECYGVPYIPEGQWLCRCCLQSPSRPVDCILCPNKGGAFKQTSDGHWA 288

  Fly   360 HVVCALWIPEVRFANTVFLEPIDSIETIPPARWRLTCYVCKEKGLGACIQCHRNSCYAAFHVTCA 424
            |||||:|||||.||||||||||:.|:.||||||:||||:||:|||||.||||:.:||.|||||||
Human   289 HVVCAIWIPEVCFANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCA 353

  Fly   425 QQAGLYMTMDTVKD-GHNDSSMHVQKFAYCHAHTP---ADAKLKMNVP----------------- 468
            |:|||:|.::.::: ..|.:...|:|.|||.||:|   |.|:.|.:.|                 
Human   354 QRAGLFMKIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPRSISETGDEEGLKEGDG 418

  Fly   469 ---DFEDTRHKMKEAR-------KALAKKR--------------------STAPVVLIPTIPPDR 503
               :.|:...:.:||:       |.:.||.                    ||.|::.:|.||..|
Human   419 EEEEEEEVEEEEQEAQGGVSGSLKGVPKKSKMSLKQKIKKEPEEAGQDTPSTLPMLAVPQIPSYR 483

  Fly   504 VQEIATMVTMQRKKEFLDRIIAYWTLKRHYRNGVPLLRRLQSQGNNHGVIQRNGIEGSPD--TGE 566
            :.:|.:.::.|||.:|:.|:..||.|||..||||||:|||.|    |...|||..:...|  |..
Human   484 LNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHS----HLQSQRNAEQREQDEKTSA 544

  Fly   567 LYRQLKYWQCLRQDLERARLLCELVRKREKLKVAFVRISEEVVMLQLNPLEAALNKLLDALEARD 631
            :..:|||||.||.||||||||.||:|||||||...|::.:..:.|:|.|....|...||.|:.:|
Human   545 VKEELKYWQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRTTLDLLQEKD 609

  Fly   632 SMQIFREPVDTSEVPDYTDIVKQPMDLGTMRAKLKECQYNSLEQLEADFDLMIQNCLAYNNKDTV 696
            ...||.|||:.||||||.:.:.:|||..|||.||:...|.:||:.|.||:|::.||:.||.|||:
Human   610 PAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEEFEEDFNLIVTNCMKYNAKDTI 674

  Fly   697 FYRAGIRMRDQAAPLFVQVRKELQRDGL-------LARSQRYH---------VDHV-----EAEV 740
            |:||.:|:||....:....|::.:..|.       |..|.:..         ||::     .|.:
Human   675 FHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFYRFSWEDVDNILIPENRAHL 739

  Fly   741 EQELRLLLAAPASEGIVQKLLILADKSQVLKNPTYRTKKIKQIRLEISRMRKSLQKARFAARHSS 805
            ..|::|           ::||...|....:::...||::::.:|.||:.:|:.|  |:.......
Human   740 SPEVQL-----------KELLEKLDLVSAMRSSGARTRRVRLLRREINALRQKL--AQPPPPQPP 791

  Fly   806 HANQSQSDDEDTLGGSPSKKRTRKRFNSSGVDMELGHDDDDEEEDSDEDSMG-------EDTVSK 863
            ..|::.|:.|  |...|       :.:::.::..|   .::.|:|.|.|...       |.|...
Human   792 SLNKTVSNGE--LPAGP-------QGDAAVLEQAL---QEEPEDDGDRDDSKLPPPPTLEPTGPA 844

  Fly   864 DLLNSTQTPPCSP-IKSLNNSSSPVGINRRTAILLTRKAQ-------AALKRPSEPLTTPVKEEQ 920
            ..|:..::||..| :|.:|:|..|      :..|..||.:       :.|:..:|||        
Human   845 PSLSEQESPPEPPTLKPINDSKPP------SRFLKPRKVEEDELLEKSPLQLGNEPL-------- 895

  Fly   921 HNSQSSNTQSTSGSSSSVTTAATAASSGAGTLNHVLSSAPPTASSFALTQNNSSGGGALASGTGI 985
                 ....|.:|                  :|.:...||.|.:            |...||.| 
Human   896 -----QRLLSDNG------------------INRLSLMAPDTPA------------GTPLSGVG- 924

  Fly   986 GGSSSAGTAAAASLTSTALAMNSKLSANLPVKSPKRPGRYRRVPEVRHSSSMSPKKSPNPAVTVS 1050
                                                    ||       :|:..||:.|      
Human   925 ----------------------------------------RR-------TSVLFKKAKN------ 936

  Fly  1051 QALPMPETLPFERIPDSFRVYRANNQRDVSDSDDAPSQSSSPCSSCSDFSMSGSCSDFDSDEASE 1115
                   .:..:|.||  ||........|:.|..:|:.......| .....|.|||:      ||
Human   937 -------GVKLQRSPD--RVLENGEDHGVAGSPASPASIEEERHS-RKRPRSRSCSE------SE 985

  Fly  1116 GDADGDPDRDGGRSRSEERDSTSQEG---TTDAMDMQHASLNNVQGNNGNMAISSSSGGSGGSSS 1177
            |:          ||..:|.::....|   .|::......||    |.:|.:|..:.||       
Human   986 GE----------RSPQQEEETGMTNGFGKHTESGSDSECSL----GLSGGLAFEACSG------- 1029

  Fly  1178 EDDELEERPLSARQNKPMKVGTRGTPTPTTMARAVALSAGRGRGKRRSNLSESTSSTATPPPLRR 1242
                                     .||..          |.|||               |.|.|
Human  1030 -------------------------LTPPK----------RSRGK---------------PALSR 1044

  Fly  1243 AGKLRSATPNASPLVNNIKARRNTTAAGSAPLTNNNRSKHSEDSASSERHNNHSHGQKPALEPLQ 1307
            .           |.:..:....:...:|.:.|.      ..||...              ||||:
Human  1045 V-----------PFLEGVNGDSDYNGSGRSLLL------PFEDRGD--------------LEPLE 1078

  Fly  1308 LVWAKCRGYPWYPALILDPKTPK-GFVYNGVPLPAPPTDVLAL---RKNCLDEIVFLVLFFDVKR 1368
            ||||||||||.|||||:|||.|: |.::||||:|.||.|||.|   ::....|.:|||||||.||
Human  1079 LVWAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFDNKR 1143

  Fly  1369 TWQWLPANKLDILGIDKQLDQQKLVESRKPAERKAVKKAYQDALHYQSQVSDLEGQGP 1426
            ||||||.:|:..||::..:|:.|::|.||.:.||:|:.||..|:.:.|:|     :||
Human  1144 TWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRV-----RGP 1196

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Br140NP_001286155.1 EPL1 <192..264 CDD:287484 43/77 (56%)
PHD_BRPF 283..336 CDD:277047 44/52 (85%)
ePHD_BRPF 340..456 CDD:277140 77/116 (66%)
Bromo_brd1_like 615..712 CDD:99944 45/96 (47%)
BR140_related 1303..1414 CDD:99900 65/114 (57%)
BRPF3NP_056510.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27 8/22 (36%)
EPL1 48..194 CDD:287484 54/151 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 75..121 5/51 (10%)
PHD_BRPF 212..265 CDD:277047 44/52 (85%)
ePHD_BRPF3 269..386 CDD:277173 77/116 (66%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 387..472 13/84 (15%)
Bromo_brd1_like 593..690 CDD:99944 45/96 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 779..897 30/150 (20%)
DUF4628 <848..972 CDD:292069 38/235 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 907..926 7/71 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 931..1015 24/115 (21%)
BR140_related 1074..1189 CDD:99900 65/114 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 199 1.000 Domainoid score I3056
eggNOG 1 0.900 - - E1_COG5141
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 728 1.000 Inparanoid score I615
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47059
OrthoDB 1 1.010 - - D566217at2759
OrthoFinder 1 1.000 - - FOG0001002
OrthoInspector 1 1.000 - - otm41684
orthoMCL 1 0.900 - - OOG6_102102
Panther 1 1.100 - - LDO PTHR13793
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1726
SonicParanoid 1 1.000 - - X459
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.870

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