DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Br140 and Jade1

DIOPT Version :9

Sequence 1:	NP_001286155.1	Gene:	Br140 / 35648	FlyBaseID:	FBgn0033155	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	XP_006500847.1	Gene:	Jade1 / 269424	MGIID:	1925835	Length:	849	Species:	Mus musculus

Alignment Length:	847	Identity:	227/847 - (26%)
Similarity:	348/847 - (41%)	Gaps:	223/847 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 PWAR-----VQVPVARVAEIPDYRVSDAPPRPLAYYRFIEKSLEEL------------------- 218
            ||.:     |||||:          ....|:|:|.....||||..:
Mouse    91 PWRQEWEKGVQVPVS----------PGTIPQPVARVVSEEKSLMFIRPKKYIASSGSEPPALGYV 145

  Fly   219 ------DGEVEYDVDEEDSAWLEHMNEERQRLGLNAVGIDTMELLMDRLEKE-----SHFQAAAN 272
                  |....||:::.|:||||..|||.:.:|:..:...|||.:::..|:.     :|......
Mouse   146 DIRTLADSVCRYDLNDMDAAWLEVTNEEFKEMGMPELDEYTMERVLEEFEQRCYDNMNHAIETEE 210

  Fly   273 GTPTGVEVDDDAVCCICLDGECQNTNVILFCDMCNLAVHQDCYGVPYIPEGQWLCRRCLQSPSKP 337
            |  .|:|.|:|.||.:|...:.::.|.::|||.||:.|||.|||:..:|||.||||.|......
Mouse   211 G--LGIEYDEDVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGVQP- 272

  Fly   338 VNCVLCPNAGGAFKQTDHG-QWAHVVCALWIPEVRFANTVFLEPIDSIETIPPARWRLTCYVCKE 401
             .|:|||..|||.|.|..| :|.||.||||||||...:...:|||..:..||.:||.|.|.:|.|
Mouse   273 -KCLLCPKKGGAMKPTRSGTKWVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALVCSLCNE 336

  Fly   402 KGLGACIQCHRNSCYAAFHVTCAQQAGLYMTMDTVKDGHNDSSMHVQKFAYCHAHTPADAKLKMN 466
            | .||.|||...:|..|||||||...||  .|.|:. ..||   .|:..:||..|:
Mouse   337 K-FGASIQCSVKNCRTAFHVTCAFDRGL--EMKTIL-AEND---EVKFKSYCPKHS--------- 385

  Fly   467 VPDFEDTRHKMKEARKALAKKRSTAP-----VVLIP--TIPPDRVQEIATMVTMQRKK------- 517
                  :..|.:|.....|.:.:.||     ..|.|  ::.|:|  |.|..|:::::|
Mouse   386 ------SHRKPEEGLGEGAAQENGAPESSPQSPLEPYGSLEPNR--EEAHRVSVRKQKLQQLEDE 442

  Fly   518 ------------------EFLDRIIAYWTLKRHYRNGVPLLRRLQSQGNNHGVIQRNGIEGSPDT 564
                              |.:|.:..||.|||......||:...:.:.:|  :.:|       :.
Mouse   443 FYTFVNLLDVARALRLPEEVVDFLYQYWKLKRKINFNKPLITPKKDEEDN--LAKR-------EQ 498

  Fly   565 GELYRQLKYWQCLRQDLERARLLCELVRKREKLKVAFVRISEEVV-----MLQLNPLEAALNKLL 624
            ..|:|:|:.:..|||||||.|.|..:|.:|||:|.:..::.|::.     :|:...:....:...
Mouse   499 DVLFRRLQLFTHLRQDLERVRNLTYMVTRREKIKRSVCKVQEQIFTQYTKLLEQEKVSGVPSSCS 563

  Fly   625 DALEARDSMQIFREPVDTSEVPDYTDIV-------KQPMDLGT-MRAKLKECQYNSLEQLEADFD 681
            .|||   :|..|..|......|...|:.       ||   :|| :...||:.....
Mouse   564 SALE---NMLFFNSPSVGPNAPKIEDLKWHSAFFRKQ---MGTSLVHPLKKSHKRD--------- 613

  Fly   682 LMIQNCLAYNNKDT------VFYRAGIRMRDQAAPL---FVQVR---KELQRDGLLA------RS 728
             .:||......|.:      ...|.|:.:.:....|   |.:.|   ...|::|::.      |.
Mouse   614 -AVQNSSGTEGKTSHKQPGLCGRREGLEVSESLLSLEKTFAEARLLSSAQQKNGVVTPDHGKRRD 677

  Fly   729 QRYHVDHVEAEVEQE--------LRLL---------LAAPASEGIVQ------KLLILADKSQVL 770
            .|:|.|.|:.:::.:        ||..         ..|..|.|:.|      |.::......::
Mouse   678 NRFHCDLVKGDLKDKSFKQSHKPLRSTDTSQRHLDNTRAATSPGVGQSAPGTRKEIVPKCNGSLV 742

  Fly   771 KNPTYRTKKIKQ---IRLEISRMRKSLQKARFAARHSSHANQSQSDDEDTLGGS--PSKKRTRKR 830
            |.|......:|.   .|:.....|:...:|...|.|       |..|...||.|  |:|:|.:.|
Mouse   743 KVPITPASPVKSWGGFRIPKKGERQQQGEAHDGACH-------QHSDCSHLGVSRAPAKERAKSR 800

  Fly   831 FNSSGVDMEL-GHDDDDEEEDSDEDSMGEDTVSKDLLNSTQTPPCSPIKSLNNSSSPVGINRRTA 894
            ..:   |.|. |:..|.|..||:.::                   |..|.::.||:   |:|||.
Mouse   801 LRA---DSENDGYAPDGEMSDSESEA-------------------SEKKCIHASST---ISRRTD 840

  Fly   895 IL 896
            |:
Mouse   841 II 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_001286155.1	EPL1	<192..264	CDD:287484	23/96 (24%)
		PHD_BRPF	283..336	CDD:277047	24/52 (46%)
		ePHD_BRPF	340..456	CDD:277140	55/116 (47%)
		Bromo_brd1_like	615..712	CDD:99944	20/113 (18%)
		BR140_related	1303..1414	CDD:99900
Jade1	XP_006500847.1	COG5141	115..>543	CDD:227470	147/464 (32%)
Jade1	XP_006500847.1	ePHD_JADE	274..384	CDD:277141	55/116 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840