DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Br140 and BRD1

DIOPT Version :9

Sequence 1:	NP_001286155.1	Gene:	Br140 / 35648	FlyBaseID:	FBgn0033155	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_001291737.1	Gene:	BRD1 / 23774	HGNCID:	1102	Length:	1189	Species:	Homo sapiens

Alignment Length:	1422	Identity:	505/1422 - (35%)
Similarity:	684/1422 - (48%)	Gaps:	333/1422 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 RNG-CSSASAGGGSASGVSARQYANPESLVSYNEEEATVTFNLDGKSVRLGIDDALPLVEDEEFA 157
            |.| |...||....:|..|.:.....|:| :|.:.:..|...::|:..|:.|.|.|.::.:::..
Human     3 RKGRCHRGSAARHPSSPCSVKHSPTRETL-TYAQAQRMVEIEIEGRLHRISIFDPLEIILEDDLT 66

  Fly   158 ALVARGCIL---NADAPPL---------------------EENAPWARVQVPVARVAEIPDYRVS 198
            |.....|..   |::.||:                     ....|.:...:|..:| .|.:|...
Human    67 AQEMSECNSNKENSERPPVCLRTKRHKNNRVKKKNEALPSAHGTPASASALPEPKV-RIVEYSPP 130

  Fly   199 DAPPRPLAYYRFIEKSLEELDGEVEYDVDEEDSAWLEHMNEERQRLGLNAVGIDTMELLMDRLEK 263
            .||.||..||:|||||.||||.|||||:||||.||||.:||:|:...:.||.....|.||||.||
Human   131 SAPRRPPVYYKFIEKSAEELDNEVEYDMDEEDYAWLEIVNEKRKGDCVPAVSQSMFEFLMDRFEK 195

  Fly   264 ESHFQAAANGTPTGVEVDDDAVCCICLDGECQNTNVILFCDMCNLAVHQDCYGVPYIPEGQWLCR 328
            |||.:....|....: :|:|||||||:||||||:|||||||||||||||:|||||||||||||||
Human   196 ESHCENQKQGEQQSL-IDEDAVCCICMDGECQNSNVILFCDMCNLAVHQECYGVPYIPEGQWLCR 259

  Fly   329 RCLQSPSKPVNCVLCPNAGGAFKQTDHGQWAHVVCALWIPEVRFANTVFLEPIDSIETIPPARWR 393
            .||||.::|.:||||||.|||||:||..:|.|||||||||||.||||||:||||.:..||||||:
Human   260 HCLQSRARPADCVLCPNKGGAFKKTDDDRWGHVVCALWIPEVGFANTVFIEPIDGVRNIPPARWK 324

  Fly   394 LTCYVCKEKGLGACIQCHRNSCYAAFHVTCAQQAGLYMTMDTVKD-GHNDSSMHVQKFAYCHAHT 457
            ||||:||:||:|||||||:.:||.||||||||:|||||.|:.||: ....::..|:|.|||..||
Human   325 LTCYLCKQKGVGACIQCHKANCYTAFHVTCAQKAGLYMKMEPVKELTGGGTTFSVRKTAYCDVHT 389

  Fly   458 P-----------ADAKLKMNVPDFEDT----------RHKMKEARKALAKKRSTAPVVLIPTIPP 501
            |           .|.::|..|...|.:          |.|.|:|:||||:..:..|.|..|.|||
Human   390 PPGCTRRPLNIYGDVEMKNGVCRKESSVKTVRSTSKVRKKAKKAKKALAEPCAVLPTVCAPYIPP 454

  Fly   502 DRVQEIATMVTMQRKKEFLDRIIAYWTLKRHYRNGVPLLRRLQSQGNNHGVIQRNGIEGSPDTGE 566
            .|:..||..|.:||||:|::|..:||.|||..|||.||||||||...:....|:.  |...:...
Human   455 QRLNRIANQVAIQRKKQFVERAHSYWLLKRLSRNGAPLLRRLQSSLQSQRSSQQR--ENDEEMKA 517

  Fly   567 LYRQLKYWQCLRQDLERARLLCELVRKREKLKVAFVRISEEVVMLQLNPLEAALNKLLDALEARD 631
            ...:|||||.||.||||||||.||:|||||||...|::.:..:.|:|.||...|..:||.|:.:|
Human   518 AKEKLKYWQRLRHDLERARLLIELLRKREKLKREQVKVEQVAMELRLTPLTVLLRSVLDQLQDKD 582

  Fly   632 SMQIFREPVDTSEVPDYTDIVKQPMDLGTMRAKLKECQYNSLEQLEADFDLMIQNCLAYNNKDTV 696
            ..:||.:||...|||||.|.:|.|||..|||.:|:...|.:|.:.|.||||:|.||:.||.:|||
Human   583 PARIFAQPVSLKEVPDYLDHIKHPMDFATMRKRLEAQGYKNLHEFEEDFDLIIDNCMKYNARDTV 647

  Fly   697 FYRAGIRMRDQAAPLFVQVRKELQRDGLLARSQRYHVDHVEAEVEQEL------RLLLAAPAS-- 753
            ||||.:|:|||...:..|.|:|:...||...|..:..:...|...:..      |||  .||:
Human   648 FYRAAVRLRDQGGVVLRQARREVDSIGLEEASGMHLPERPAAAPRRPFSWEDVDRLL--DPANRA 710

  Fly   754 ----EGIVQKLLILADKSQVLKNPTYRTKKIKQIRLEISRMRKSLQKARFAARHSSHANQSQSDD 814
                |..:::||.:.|.:..:|:...|:|:.|.::.||:.:|..|.:.......:....:...:|
Human   711 HLGLEEQLRELLDMLDLTCAMKSSGSRSKRAKLLKKEIALLRNKLSQQHSQPLPTGPGLEGFEED 775

  Fly   815 EDTLGGSPSKKRTRKRFNSSGVDMELGHDDDDEEEDSDEDSMGEDTVSKDLLNSTQTPPCSPIKS 879
            ...||                  .|.|.:.|.                            ||.|.
Human   776 GAALG------------------PEAGEEGDK----------------------------SPPKL 794

  Fly   880 LNNSSSPVGINRRTAILLTRKAQAALKRPSEPLT-TPVKEEQHNSQSSNTQSTSGSSSSVTTAAT 943
            ..:.:.|:..|..|              .|||.| .||:.....|:.....:....|.|..|.:.
Human   795 EPSDALPLPSNSET--------------NSEPPTLKPVELNPEQSKLFKRVTFDNESHSACTQSA 845

  Fly   944 AASSGAGTLNHVLSSAPPTASSFALTQNNSSGGGALASGTGIGGSSSAGTAAAASLTSTALAMNS 1008
                       ::|..||..:       .:|.|...|             |||:::...|..:|.
Human   846 -----------LVSGRPPEPT-------RASSGDVPA-------------AAASAVAEPASDVNR 879

  Fly  1009 KLSANLPVKSPKRPGRYRRVPEVRHSSSMSPKKSPNPAVT------------VSQALPMPETLPF 1061
            :.|. |..|                |.|:||.||.....|            :|..||..|||..
Human   880 RTSV-LFCK----------------SKSVSPPKSAKNTETQPTSPQLGTKTFLSVVLPRLETLLQ 927

  Fly  1062 ERIPDSFRVYRANNQRDVSDSDDAPSQSSSPCSSCSDFSMSGSCSDFDSDEASEGDADGDPDRDG 1126
            .|                       .:|.|.|                      ||::.:.:..|
Human   928 PR-----------------------KRSRSTC----------------------GDSEVEEESPG 947

  Fly  1127 GRSRSEERDSTSQEGTTDAMDMQHASLNNVQGNNGNMAISSSSGGSGGSSSEDDELEERPLSARQ 1191
            .|                 :|   |.|.|               |.||:.||            |
Human   948 KR-----------------LD---AGLTN---------------GFGGARSE------------Q 965

  Fly  1192 NKPMKVGTRGTPTPTTMARAVALSAGRGRGKRRSNLSESTSSTATPP--------PLRRAGK--- 1245
            .....:|.:.||                   ||...|||:.|::..|        |....||
Human   966 EPGGGLGRKATP-------------------RRRCASESSISSSNSPLCDSSFNAPKCGRGKPAL 1011

  Fly  1246 -LRSATPNASPLVNNIKARRNTTAAGSAPLTNNNRSKHSEDSASSERHNNHSHGQKPALEPLQLV 1309
             .|....:.|.|::.|:......||..|.....:....|.|:|:|            .||||::|
Human  1012 VRRHTLEDRSELISCIENGNYAKAARIAAEVGQSSMWISTDAAAS------------VLEPLKVV 1064

  Fly  1310 WAKCRGYPWYPALILDPKTPK--GFVYNGVPLPAPPTDVLALRKNC---LDEIVFLVLFFDVKRT 1369
            ||||.|||.|||||:|||.|:  |. :|||.:||||.|||.:.::.   .||.:|||||||.||:
Human  1065 WAKCSGYPSYPALIIDPKMPRVPGH-HNGVTIPAPPLDVLKIGEHMQTKSDEKLFLVLFFDNKRS 1128

  Fly  1370 WQWLPANKLDILGIDKQLDQQKLVESRKPAERKAVKKAYQDALHYQSQV-----SDL 1421
            |||||.:|:..||||:.:|:.|::|.|..:.||||:.|:..|:::.|:|     |||
Human  1129 WQWLPKSKMVPLGIDETIDKLKMMEGRNSSIRKAVRIAFDRAMNHLSRVHGEPTSDL 1185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_001286155.1	EPL1	<192..264	CDD:287484	41/71 (58%)
		PHD_BRPF	283..336	CDD:277047	47/52 (90%)
		ePHD_BRPF	340..456	CDD:277140	79/116 (68%)
		Bromo_brd1_like	615..712	CDD:99944	48/96 (50%)
		BR140_related	1303..1414	CDD:99900	63/115 (55%)
BRD1	NP_001291737.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		7/22 (32%)
		Interaction with KAT7/HBO1 and histones. /evidence=ECO:0000269\|PubMed:28334966	31..80		10/49 (20%)
		EPL1	47..196	CDD:287484	53/149 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	92..116		1/23 (4%)
		PHD_BRPF2	214..267	CDD:277147	47/52 (90%)
		ePHD_BRPF2	271..388	CDD:277172	79/116 (68%)
		Bromo_brd1_like	566..663	CDD:99944	48/96 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	755..776		1/20 (5%)
		BR140_related	1058..1173	CDD:99900	63/115 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3056
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	728	1.000	Inparanoid score	I615
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47059
OrthoDB	1	1.010	-	-		D566217at2759
OrthoFinder	1	1.000	-	-		FOG0001002
OrthoInspector	1	1.000	-	-		otm41684
orthoMCL	1	0.900	-	-		OOG6_102102
Panther	1	1.100	-	-	O	PTHR13793
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	1	1.000	-	-		X459
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	12.010