Protein Alignment Br140 and JADE2

DIOPT Version :9

• Sequence 1: NP_001286155.1
• Gene: Br140 / 35648
• FlyBaseID: FBgn0033155
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: NP_001276914.1
• Gene: JADE2 / 23338
• HGNCID: 22984
• Length: 850
• Species: Homo sapiens
• Alignment Length: 1122
• Identity: 268/1122 - (23%)
• Similarity: 385/1122 - (34%)
• Gaps: 364/1122 - (32%)

  Fly    88 GGGAEARNGCSSASAGGGS----ASGVSARQYAN-PESLVS----YNEEEATVTFNLDGKSVRLG 143
            ||..|.|...|.:|....:    |:..||.:.:. |.|..|    .||::.:..|..| ....:.
Human    15 GGMEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTD-LITAMK 78

  Fly   144 IDDALPLVEDEEFAALVARGCILNADAPPLEENAPWAR-----VQVPVARVAEIPDYRVSDAPP- 202
            |.|:..|..|:.:         :.||        ||.:     ||||....| ||:..|...||
Human    79 IPDSYQLSPDDYY---------ILAD--------PWRQEWEKGVQVPAGAEA-IPEPVVRILPPL 125

  Fly   203 -RPLAY-----YRFIEKSLEELDGEVEYDVDEEDSAWLEHMNEERQRLGLNAVGIDTMELLMDRL 261
             .|.|.     ....|.|..:..|...||:||.|:.|||.:|.|.:.:....:...|:|.:::.|
Human   126 EGPPAQASPSSTMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDELTLERVLEEL 190

  Fly   262 EKESHFQAAANGTPT----GVEVDDDAVCCICLDGECQNTNVILFCDMCNLAVHQDCYGVPYIPE 322
            |...| |..|....|    |:|.|:|.||.:|...|.::.|.::|||.||:.|||.|||:..:|.
Human   191 ETLCH-QNMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPT 254

  Fly   323 GQWLCRRCLQSPSKPVNCVLCPNAGGAFKQTDHG-QWAHVVCALWIPEVRFANTVFLEPIDSIET 386
            |.||||.|......  .|:|||..|||.|.|..| :|.||.||||||||.......:|||..|..
Human   255 GSWLCRTCALGVQP--KCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKISH 317

  Fly   387 IPPARWRLTCYVCKEKGLGACIQCHRNSCYAAFHVTCAQQAGLYMTMDTVKDGHNDSSMHVQKFA 451
            ||.:||.|:|.:||| ..|.||||...||..|||||||...||  .|.|:. ..||   .|:..:
Human   318 IPASRWALSCSLCKE-CTGTCIQCSMPSCVTAFHVTCAFDHGL--EMRTIL-ADND---EVKFKS 375

  Fly   452 YCHAHTPADAKLKMNVPDFEDTRHKM--KEARKALAKKRSTAPVV--LIPTIPPDRVQEIATMVT 512
            :|..|:....:   |.|..|.|....  ::..|...:|:....:.  ....:.|..|.|     .
Human   376 FCQEHSDGGPR---NEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDFYELVEPAEVAE-----R 432

  Fly   513 MQRKKEFLDRIIAYWTLKRHYRNGVPLLRRLQSQGNNHGVIQRNGIEGSPDTGE----------- 566
            :...:..:|.|..||.|||......|||                    :|.|.|
Human   433 LDLAEALVDFIYQYWKLKRKANANQPLL--------------------TPKTDEVDNLAQQEQDV 477

  Fly   567 LYRQLKYWQCLRQDLERARLLCELVRKREKLKVAFVRISEEVVMLQLNPLEAALNKLLDALEARD 631
            |||:||.:..|||||||.|.||.:|.:||:.|.|..::.|::..||:..:|.      |....|.
Human   478 LYRRLKLFTHLRQDLERVRNLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQ------DLCRERS 536

  Fly   632 SMQIFREPVDTSEVPDYTDIVKQPMDLGTMRAKLKECQ--YNSLEQLEADFDLMIQNCLAYNNKD 694
            ..:...:..|                     :|.|.|:  ..|.|:.|
Human   537 GRRAKGKKSD---------------------SKRKGCEGSKGSTEKKE----------------- 563

  Fly   695 TVFYRAGIRMRDQAAPLFVQVRKELQRDGLLAR----SQRYHVDHVEAEVEQELRLLLAAPASEG 755
                      :.:|.|           |.:|.:    |..:.:|              ....:..
Human   564 ----------KVKAGP-----------DSVLGQLAGLSTSFPID--------------GTFFNSW 593

  Fly   756 IVQKLLILADKSQVLKNPTYRTKKIKQIRLEISRMRKSLQKARFAARHSSHANQSQSDDEDTLGG 820
            :.|.:.|.|:...:.:.|
Human   594 LAQSVQITAENMAMSEWP----------------------------------------------- 611

  Fly   821 SPSKKRTRKRFNSSGVDMELGHDDD------DEEEDSDEDSMGEDTVSKDLLNSTQTPPCSPIKS 879
                             :..||.:|      .||...||::         ||:..:.|...|
Human   612 -----------------LNNGHREDPAPGLLSEELLQDEET---------LLSFMRDPSLRP--- 647

  Fly   880 LNNSSSPVGINRRTAILLTRKAQAALKRPSEPLTTPVKEEQHNSQSSNTQSTSGSSSSVTTAATA 944
                ..|           .|||:...:.|::....|..     .|......|:...:...|....
Human   648 ----GDP-----------ARKARGRTRLPAKKKPPPPP-----PQDGPGSRTTPDKAPKKTWGQD 692

  Fly   945 ASSGAGTLNHVLSSAPPTASSFALTQNNSSGGGALASGTGIGGSSSAGT-------AAAASLTST 1002
            |.||.|      ...|||......|.::      |.|....|......|       |......:.
Human   693 AGSGKG------GQGPPTRKPPRRTSSH------LPSSPAAGDCPILATPESPPPLAPETPDEAA 745

  Fly  1003 ALAMNSKLSANLPVKSPKRPGRY---------RRVPEVRHSSSMSPKKSPNPAVTVSQALPMPET 1058
            ::|.:|.:....|..|||..||.         ||:|..|..:.|.|..:......||
Human   746 SVAADSDVQVPGPAASPKPLGRLRPPRESKVTRRLPGARPDAGMGPPSAVAERPKVS-------- 802

  Fly  1059 LPFERIPDSFRVYRANNQRDVSDSDDAPSQSSSPCSSCSDFSMSGSCSDFDSDEASEGDADGDPD 1123
            |.|:...|.:                                       |...|.|:.|.:.:
Human   803 LHFDTETDGY---------------------------------------FSDGEMSDSDVEAE-- 826

  Fly  1124 RDGGRSRSEERDSTSQE 1140
             |||..|. .|::.::|
Human   827 -DGGVQRG-PREAGAEE 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_001286155.1	EPL1	<192..264	CDD:287484	24/78 (31%)
		PHD_BRPF	283..336	CDD:277047	24/52 (46%)
		ePHD_BRPF	340..456	CDD:277140	56/116 (48%)
		Bromo_brd1_like	615..712	CDD:99944	12/98 (12%)
		BR140_related	1303..1414	CDD:99900
JADE2	NP_001276914.1	EPL1	<153..191	CDD:287484	12/37 (32%)
		PHD_JADE2	217..262	CDD:277150	22/44 (50%)
		ePHD_JADE2	270..380	CDD:277175	56/116 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810