DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Br140 and Brd1

DIOPT Version :9

Sequence 1:	NP_001286155.1	Gene:	Br140 / 35648	FlyBaseID:	FBgn0033155	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_001028446.2	Gene:	Brd1 / 223770	MGIID:	1924161	Length:	1189	Species:	Mus musculus

Alignment Length:	1429	Identity:	498/1429 - (34%)
Similarity:	686/1429 - (48%)	Gaps:	347/1429 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 RNG-CSSASAGGGSASGVSARQYANPESLVSYNEEEATVTFNLDGKSVRLGIDDALPLVEDEEFA 157
            |.| |...||....:|..|.:.....|:| :|.:.:..|...::|:..|:.|.|.|.::.:::..
Mouse     3 RKGRCHRGSAARHPSSPCSIKHSPTRETL-TYAQAQRMVEIEIEGRLHRISIFDPLEIILEDDLT 66

  Fly   158 ALVARGCIL---NADAPPL---------------------EENAPWARVQVPVARVAEIPDYRVS 198
            |.....|..   |::.||:                     ....|.:...:|..:| .|.:|...
Mouse    67 AQEMSECNSNKENSERPPVCLRTKRHKNNRVKKKNEVLPSTHGTPASASALPEPKV-RIVEYSPP 130

  Fly   199 DAPPRPLAYYRFIEKSLEELDGEVEYDVDEEDSAWLEHMNEERQRLGLNAVGIDTMELLMDRLEK 263
            .||.||..||:|||||.||||.|||||:||||.||||.:||:|:...::||..:..|.||||.||
Mouse   131 SAPRRPPVYYKFIEKSAEELDNEVEYDMDEEDYAWLEIINEKRKGDCVSAVSQNMFEFLMDRFEK 195

  Fly   264 ESHFQAAANGTPTGVEVDDDAVCCICLDGECQNTNVILFCDMCNLAVHQDCYGVPYIPEGQWLCR 328
            ||:.:....|....: :|:|||||||:||||||:|||||||||||||||:|||||||||||||||
Mouse   196 ESYCENQKQGEQQSL-IDEDAVCCICMDGECQNSNVILFCDMCNLAVHQECYGVPYIPEGQWLCR 259

  Fly   329 RCLQSPSKPVNCVLCPNAGGAFKQTDHGQWAHVVCALWIPEVRFANTVFLEPIDSIETIPPARWR 393
            .||||.::|.:||||||.|||||:||..:|.|||||||||||.||||||:||||.:..||||||:
Mouse   260 HCLQSRARPADCVLCPNKGGAFKKTDDDRWGHVVCALWIPEVGFANTVFIEPIDGVRNIPPARWK 324

  Fly   394 LTCYVCKEKGLGACIQCHRNSCYAAFHVTCAQQAGLYMTMDTVKD-GHNDSSMHVQKFAYCHAHT 457
            ||||:||:||:|||||||:.:||.||||||||:|||||.|:.||: ....::..|:|.|||..||
Mouse   325 LTCYLCKQKGVGACIQCHKANCYTAFHVTCAQKAGLYMKMEPVKELTGGSATFSVRKTAYCDVHT 389

  Fly   458 P-----------ADAKLKMNVPDFEDT----------RHKMKEARKALAKKRSTAPVVLIPTIPP 501
            |           .|.::|..|...|.:          |.|.|:|:|.||:..:..|.|..|.|||
Mouse   390 PPGCTRRPLNIYGDVEMKNGVCRKESSVKTVRSTSKVRKKAKKAKKTLAEPCAVLPTVCAPYIPP 454

  Fly   502 DRVQEIATMVTMQRKKEFLDRIIAYWTLKRHYRNGVPLLRRLQSQGNNHGVIQRNGIEGSPDTGE 566
            .|:..||..|.:||||:|::|..:||.|||..|||.||||||||...:....|:.  |...:...
Mouse   455 QRLNRIANQVAIQRKKQFVERAHSYWLLKRLSRNGAPLLRRLQSSLQSQRNTQQR--ENDEEMKA 517

  Fly   567 LYRQLKYWQCLRQDLERARLLCELVRKREKLKVAFVRISEEVVMLQLNPLEAALNKLLDALEARD 631
            ...:|||||.||.||||||||.||:|||||||...|::.:..:.|:|.||...|..:|:.|:.:|
Mouse   518 AKEKLKYWQRLRHDLERARLLIELLRKREKLKREQVKVEQMAMELRLTPLTVLLRSVLEQLQEKD 582

  Fly   632 SMQIFREPVDTSEVPDYTDIVKQPMDLGTMRAKLKECQYNSLEQLEADFDLMIQNCLAYNNKDTV 696
            ..:||.:||...|||||.|.:|.|||..|||.:|:...|.:|...|.||:|::.||:.||.||||
Mouse   583 PAKIFAQPVSLKEVPDYLDHIKHPMDFATMRKRLEAQGYKNLHAFEEDFNLIVDNCMKYNAKDTV 647

  Fly   697 FYRAGIRMRDQAAPLFVQVRKELQR----------------------------DGLLARSQRYHV 733
            ||||.:|:|||...:..|.|:|::.                            |.||..:.|.|:
Mouse   648 FYRAAVRLRDQGGVVLRQARREVESIGLEEASGMHLPERPIAAPRRPFSWEEVDRLLDPANRAHM 712

  Fly   734 DHVEAEVEQELRLLLAAPASEGIVQKLLILADKSQVLKNPTYRTKKIKQIRLEISRMRKSLQKAR 798
                 .:|::||.||         .||    |.:..:|:...|:|:.|.::.||:.:|..|
Mouse   713 -----SLEEQLRELL---------DKL----DLTCSMKSSGSRSKRAKLLKKEIALLRNKL---- 755

  Fly   799 FAARHSSHANQSQSDDEDTLGGSPSKKRTRKRFNSSGVDMELGHDDDDEEEDSDEDSMGEDTVSK 863
                     :|..|....|..|:.                  |.:|
Mouse   756 ---------SQQHSQAPPTGAGTG------------------GFED------------------- 774

  Fly   864 DLLNSTQTPPCSPIKSLNNSSSPVGINRRTAILLTRKAQAALKRPSEPLT-TPVKEEQHNSQSSN 927
                  :..|.:|..:...::||..:....|:.|...::.    .|||.| .||  |.|..||..
Mouse   775 ------EAAPLAPDTAEEGANSPPKLEPSDALPLPSNSET----NSEPPTLNPV--ELHPEQSKL 827

  Fly   928 TQSTSGSSSSVTTAATAASSGAGTLNHVLSSAPPTASSFALTQNNSSGGGALASGTGIGGSSSAG 992
            .:..:..:.|.:|...:|         ::|..||..:              |||      |....
Mouse   828 FKRVTFDNESHSTCTQSA---------LVSGHPPEPT--------------LAS------SGDVP 863

  Fly   993 TAAAASLTSTALAMNSKLSANLPVKSPKRPGRYRRVPEVRHSSSMSPKKSPNPAVT--------- 1048
            .|||:::...:..:|.:.|. |..|                |.|:||.||.....|
Mouse   864 AAAASAVAEPSSDVNRRTSV-LFCK----------------SKSVSPPKSAKNTETQPTSPQLGT 911

  Fly  1049 ---VSQALPMPETL--PFERIPDSFRVYRANNQRDVSDSDDAPSQSSSPCSSCSDFSMSGSCSDF 1108
               :|..||..|||  |.:|                       |:|              :|.|.
Mouse   912 KTFLSVVLPRLETLLQPRKR-----------------------SRS--------------TCGDS 939

  Fly  1109 DSDEASEGD-ADGDPDRDGGRSRSEERDSTSQEGTTDAMDMQHASLNNVQGNNGNMAISSSSGGS 1172
            :.:|.|.|. .|.......|.:|||:                                 ...||.
Mouse   940 EVEEESPGKRLDTGLTNGFGGARSEQ---------------------------------EPGGGP 971

  Fly  1173 GGSSSEDDELEERPLSARQNKPMKVGTRGTPTPTTMARAVALSAGRGRGKRRSNLSESTSSTATP 1237
            |..::..............|.|:...:..||           ..|||:
Mouse   972 GRKAAPRRRCASESSICSSNSPLCDSSFSTP-----------KCGRGK----------------- 1008

  Fly  1238 PPLRRAGKLRSATPNASPLVNNIKARRNTTAAGSAPLTNNNRSKHSEDSASSERHNNHSHGQKPA 1302
            |.|.|    |....:.|.|::.|:......||..|.....:....|.|:|:|            .
Mouse  1009 PALVR----RHTLEDRSELISCIENGNYAKAARIAAEVGQSNMWISTDAAAS------------V 1057

  Fly  1303 LEPLQLVWAKCRGYPWYPALILDPKTPK--GFVYNGVPLPAPPTDVLALRKNC---LDEIVFLVL 1362
            ||||::|||||.|||.|||||:|||.|:  |. :|||.:||||.|||.:.::.   .:|.:||||
Mouse  1058 LEPLKVVWAKCSGYPSYPALIIDPKMPRVPGH-HNGVTIPAPPLDVLKIGEHMQTKSEEKLFLVL 1121

  Fly  1363 FFDVKRTWQWLPANKLDILGIDKQLDQQKLVESRKPAERKAVKKAYQDALHYQSQV-----SDL 1421
            |||.||:|||||.:|:..||:|:.:|:.|::|.|..:.||||:.|:..|:::.|:|     |||
Mouse  1122 FFDNKRSWQWLPKSKMVPLGVDETIDKLKMMEGRNSSIRKAVRIAFDRAMNHLSRVHGEPASDL 1185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_001286155.1	EPL1	<192..264	CDD:287484	41/71 (58%)
		PHD_BRPF	283..336	CDD:277047	47/52 (90%)
		ePHD_BRPF	340..456	CDD:277140	79/116 (68%)
		Bromo_brd1_like	615..712	CDD:99944	46/96 (48%)
		BR140_related	1303..1414	CDD:99900	61/115 (53%)
Brd1	NP_001028446.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		7/21 (33%)
		Interaction with KAT7/HBO1 and histones. /evidence=ECO:0000250\|UniProtKB:O95696	31..80		10/49 (20%)
		EPL1	47..196	CDD:287484	53/149 (36%)
		PHD_BRPF2	214..267	CDD:277147	47/52 (90%)
		ePHD_BRPF2	271..388	CDD:277172	79/116 (68%)
		Bromo_brd1_like	566..663	CDD:99944	46/96 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	754..776		7/77 (9%)
		BR140_related	1058..1173	CDD:99900	61/115 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3057
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	735	1.000	Inparanoid score	I600
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47059
OrthoDB	1	1.010	-	-		D566217at2759
OrthoFinder	1	1.000	-	-		FOG0001002
OrthoInspector	1	1.000	-	-		otm43732
orthoMCL	1	0.900	-	-		OOG6_102102
Panther	1	1.100	-	-	O	PTHR13793
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	1	1.000	-	-		X459
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870