DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Br140 and lin-49

DIOPT Version :9

Sequence 1:	NP_001286155.1	Gene:	Br140 / 35648	FlyBaseID:	FBgn0033155	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_501475.1	Gene:	lin-49 / 177666	WormBaseID:	WBGene00003034	Length:	1042	Species:	Caenorhabditis elegans

Alignment Length:	907	Identity:	261/907 - (28%)
Similarity:	403/907 - (44%)	Gaps:	171/907 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 PPLEENAPWARVQVPVA-----RVAEIPDYRVSDAPPRPLAYYRFIEKSLEELDGE-VEYDVDEE 229
            ||::...  |.:..|||     .:.:.|:::...            ||...|.|.: |:|.|||.
Worm    90 PPIQRVD--AHIVTPVAGKCGMPLQKFPEFKHDH------------EKIKIERDAKYVDYSVDEF 140

  Fly   230 DSAWLEHMNEERQRLGLNAVGIDTMELLMDRLE-------KESHFQAAANGTPTGVEVDDDAVCC 287
            |.:|:..||.:|.:|||....:...|..:||||       ||.|.....||.    |:||  ||.
Worm   141 DMSWMSIMNAKRTKLGLEIFSVAIYEHWVDRLEKMCIWKPKEFHKLKDENGE----ELDD--VCN 199

  Fly   288 ICLDGECQNTNVILFCDMCNLAVHQDCYGVPYIPEGQWLCRRCLQSPSKPVNCVLCPNAGGAFKQ 352
            |||||:..|.|.|::||.|||:|||||||:|:||||...||||..||:..|||||||:..|||||
Worm   200 ICLDGDTSNCNQIVYCDRCNLSVHQDCYGIPFIPEGCLECRRCGISPAGRVNCVLCPSTTGAFKQ 264

  Fly   353 TDHGQWAHVVCALWIPEVRFANTVFLEPIDSIETIPPARWRLTCYVCKEK---GLGACIQCHRNS 414
            .|..:|.||:|.:|:.|..|.||:|:|.:.::|.....|..|:|.:||.:   .:||||||....
Worm   265 VDQKRWVHVLCVIWVDETHFGNTIFMENVQNVEKALHDRRALSCLLCKNRQNARMGACIQCSETK 329

  Fly   415 CYAAFHVTCAQQAGLYMTMDTVKDGHNDSSMHVQKFAYCHAHTP--ADAKLKMNVPDFEDTRHKM 477
            |.|:||||||:.:||.|.::..:||      .|.:|.:|..|.|  .||       |.|..:..:
Worm   330 CTASFHVTCARDSGLVMRINETEDG------QVNRFVWCPKHAPPLTDA-------DREMRQLML 381

  Fly   478 KEARKALAKKRSTAPVVLIPTIPPDRVQEIATMVTMQRKKEFLDRIIAYWTLKRHYRNGVPLLRR 542
            :.||:...:|   .|::.:||:    ::.:.:.:.::|.......||.:|..||..|.|.|||:.
Worm   382 RNARRENERK---GPMISMPTL----MKSMISTICVERPFSDYSEIIYFWYEKRLNRLGAPLLKN 439

  Fly   543 L-QSQGNNHGVIQRNGIEGSPDTGELYRQLKYWQCLRQDLERARLLCELVRKREKLKV----AFV 602
            . |....:..::.::.|.|.....|.....|....:::.|.....:.:::.:||:.|.    :::
Worm   440 FTQGASKSRRLLPKSTICGQLKNVETCEMKKQVNAVKESLASGLEIFDMIVRREERKKDMLNSYI 504

  Fly   603 RISEEVVMLQLNPLEAALNKLLDALEARDSMQIFREPVDTSEVPDYTDIVKQPMDLGTMRAKLKE 667
            |:.|.    ...|.|....::::||:..|:.::|.|||   |:..||||::.|:.|..|..|...
Worm   505 RMFER----GFKPTELLCQEVIEALKTIDAGKVFAEPV---ELVGYTDIIENPICLKDMSEKAAS 562

  Fly   668 CQYNSLEQLEADFDLMIQNCLAYNNKDTVFYRAGIRMRDQAAPLFVQVRKELQRDGLLARSQRYH 732
            .:|:::..|.||..||:.||..:|..:.|:.:.|...|..:.|:.....||
Worm   563 GKYSTVAALSADVQLMLSNCATFNKGNRVYIKYGNTYRKDSTPILEIAEKE-------------- 613

  Fly   733 VDHVEAEVEQELRLLLAAPASEGIVQKLLILADKSQVLKNPTYRTKKIKQIRLEISRMRKSLQKA 797
                  |||:     ||....|..:.:||     :.|:.......:...::..||.....|..:.
Worm   614 ------EVER-----LALKTDEKFMTQLL-----NGVMVEYNGWAQSRNEVAKEIPPPTPSRGRG 662

  Fly   798 RFAARHSSHANQSQSDDEDTLGGS-------PSKKRTRKRFNSSGVDMELGHDDDDEEEDSD--E 853
            ....|.:...:..:.|.:|:...|       .|||.:|||          |..|...|||.:  .
Worm   663 TGRRRQNPFLDVQELDTDDSKDSSALSEIPGSSKKSSRKR----------GIQDTKMEEDEEIKP 717

  Fly   854 DSMGEDTV-----------SKDLLNSTQTPPCSPIKSLNNSSSPVGINRRTAILLTRKAQAALKR 907
            .:.|.:.|           ||:...|:.....||..|...|.|       |:..|.|:.|.....
Worm   718 STSGTNAVASVPLLSSSRESKNKSKSSDADVSSPKSSWLGSPS-------TSQNLRRRVQGFSGN 775

  Fly   908 PSEPLTTPVKEEQHNSQSSNTQSTS---------GSSSSVTTA-ATAASSGAGTLN---HVLSSA 959
            .|.| ....|....|..:||.:.|:         .:...||.| .||..||:|..|   ..|...
Worm   776 ESSP-KVHKKLSTDNPSNSNLRQTTLTNFFGTNPKTQQQVTFADMTATPSGSGNKNVSQRSLFDT 839

  Fly   960 PPT--ASSFALTQNNSSGGGALASGTGIGGSSSAGTAAAASLTSTALAMNSKLSANLPVKSP 1019
            |.|  ||||                |.:  ||:..:..:.|:..|....|:...::..::||
Worm   840 PSTSKASSF----------------TSL--SSTRPSTRSTSIIPTINKKNAFRMSSASIQSP 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_001286155.1	EPL1	<192..264	CDD:287484	23/79 (29%)
		PHD_BRPF	283..336	CDD:277047	33/52 (63%)
		ePHD_BRPF	340..456	CDD:277140	50/118 (42%)
		Bromo_brd1_like	615..712	CDD:99944	31/96 (32%)
		BR140_related	1303..1414	CDD:99900
lin-49	NP_501475.1	EPL1	<61..174	CDD:287484	28/97 (29%)
		PHD_BRPF_JADE_like	197..242	CDD:276967	29/44 (66%)
		zf-HC5HC2H_2	251..365	CDD:290544	51/119 (43%)
		BROMO	508..610	CDD:197636	32/108 (30%)
		Sporozoite_P67	642..>1029	CDD:253298	63/278 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159936
Domainoid	1	1.000	119	1.000	Domainoid score	I3613
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	307	1.000	Inparanoid score	I1581
Isobase	1	0.950	-	0	Normalized mean entropy	S3175
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D566217at2759
OrthoFinder	1	1.000	-	-		FOG0001002
OrthoInspector	1	1.000	-	-		oto18948
orthoMCL	1	0.900	-	-		OOG6_102102
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	1	1.000	-	-		X459
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.680