Protein Alignment Br140 and lin-49

DIOPT Version :10

• Sequence 1: NP_610266.1
• Gene: Br140 / 35648
• FlyBaseID: FBgn0033155
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: NP_501475.1
• Gene: lin-49 / 177666
• WormBaseID: WBGene00003034
• Length: 1042
• Species: Caenorhabditis elegans
• Alignment Length: 907
• Identity: 261/907 - (28%)
• Similarity: 403/907 - (44%)
• Gaps: 171/907 - (18%)

  Fly   171 PPLEENAPWARVQVPVA-----RVAEIPDYRVSDAPPRPLAYYRFIEKSLEELDGE-VEYDVDEE 229
            ||::...  |.:..|||     .:.:.|:::...            ||...|.|.: |:|.|||.
 Worm    90 PPIQRVD--AHIVTPVAGKCGMPLQKFPEFKHDH------------EKIKIERDAKYVDYSVDEF 140

  Fly   230 DSAWLEHMNEERQRLGLNAVGIDTMELLMDRLE-------KESHFQAAANGTPTGVEVDDDAVCC 287
            |.:|:..||.:|.:|||....:...|..:||||       ||.|.....||.    |:||  ||.
 Worm   141 DMSWMSIMNAKRTKLGLEIFSVAIYEHWVDRLEKMCIWKPKEFHKLKDENGE----ELDD--VCN 199

  Fly   288 ICLDGECQNTNVILFCDMCNLAVHQDCYGVPYIPEGQWLCRRCLQSPSKPVNCVLCPNAGGAFKQ 352
            |||||:..|.|.|::||.|||:|||||||:|:||||...||||..||:..|||||||:..|||||
 Worm   200 ICLDGDTSNCNQIVYCDRCNLSVHQDCYGIPFIPEGCLECRRCGISPAGRVNCVLCPSTTGAFKQ 264

  Fly   353 TDHGQWAHVVCALWIPEVRFANTVFLEPIDSIETIPPARWRLTCYVCKEK---GLGACIQCHRNS 414
            .|..:|.||:|.:|:.|..|.||:|:|.:.::|.....|..|:|.:||.:   .:||||||....
 Worm   265 VDQKRWVHVLCVIWVDETHFGNTIFMENVQNVEKALHDRRALSCLLCKNRQNARMGACIQCSETK 329

  Fly   415 CYAAFHVTCAQQAGLYMTMDTVKDGHNDSSMHVQKFAYCHAHTP--ADAKLKMNVPDFEDTRHKM 477
            |.|:||||||:.:||.|.::..:||      .|.:|.:|..|.|  .||       |.|..:..:
 Worm   330 CTASFHVTCARDSGLVMRINETEDG------QVNRFVWCPKHAPPLTDA-------DREMRQLML 381

  Fly   478 KEARKALAKKRSTAPVVLIPTIPPDRVQEIATMVTMQRKKEFLDRIIAYWTLKRHYRNGVPLLRR 542
            :.||:...:|   .|::.:||:    ::.:.:.:.::|.......||.:|..||..|.|.|||:.
 Worm   382 RNARRENERK---GPMISMPTL----MKSMISTICVERPFSDYSEIIYFWYEKRLNRLGAPLLKN 439

  Fly   543 L-QSQGNNHGVIQRNGIEGSPDTGELYRQLKYWQCLRQDLERARLLCELVRKREKLKV----AFV 602
            . |....:..::.::.|.|.....|.....|....:::.|.....:.:::.:||:.|.    :::
 Worm   440 FTQGASKSRRLLPKSTICGQLKNVETCEMKKQVNAVKESLASGLEIFDMIVRREERKKDMLNSYI 504

  Fly   603 RISEEVVMLQLNPLEAALNKLLDALEARDSMQIFREPVDTSEVPDYTDIVKQPMDLGTMRAKLKE 667
            |:.|.    ...|.|....::::||:..|:.::|.|||   |:..||||::.|:.|..|..|...
 Worm   505 RMFER----GFKPTELLCQEVIEALKTIDAGKVFAEPV---ELVGYTDIIENPICLKDMSEKAAS 562

  Fly   668 CQYNSLEQLEADFDLMIQNCLAYNNKDTVFYRAGIRMRDQAAPLFVQVRKELQRDGLLARSQRYH 732
            .:|:::..|.||..||:.||..:|..:.|:.:.|...|..:.|:.....||
 Worm   563 GKYSTVAALSADVQLMLSNCATFNKGNRVYIKYGNTYRKDSTPILEIAEKE-------------- 613

  Fly   733 VDHVEAEVEQELRLLLAAPASEGIVQKLLILADKSQVLKNPTYRTKKIKQIRLEISRMRKSLQKA 797
                  |||:     ||....|..:.:||     :.|:.......:...::..||.....|..:.
 Worm   614 ------EVER-----LALKTDEKFMTQLL-----NGVMVEYNGWAQSRNEVAKEIPPPTPSRGRG 662

  Fly   798 RFAARHSSHANQSQSDDEDTLGGS-------PSKKRTRKRFNSSGVDMELGHDDDDEEEDSD--E 853
            ....|.:...:..:.|.:|:...|       .|||.:|||          |..|...|||.:  .
 Worm   663 TGRRRQNPFLDVQELDTDDSKDSSALSEIPGSSKKSSRKR----------GIQDTKMEEDEEIKP 717

  Fly   854 DSMGEDTV-----------SKDLLNSTQTPPCSPIKSLNNSSSPVGINRRTAILLTRKAQAALKR 907
            .:.|.:.|           ||:...|:.....||..|...|.|       |:..|.|:.|.....
 Worm   718 STSGTNAVASVPLLSSSRESKNKSKSSDADVSSPKSSWLGSPS-------TSQNLRRRVQGFSGN 775

  Fly   908 PSEPLTTPVKEEQHNSQSSNTQSTS---------GSSSSVTTA-ATAASSGAGTLN---HVLSSA 959
            .|.| ....|....|..:||.:.|:         .:...||.| .||..||:|..|   ..|...
 Worm   776 ESSP-KVHKKLSTDNPSNSNLRQTTLTNFFGTNPKTQQQVTFADMTATPSGSGNKNVSQRSLFDT 839

  Fly   960 PPT--ASSFALTQNNSSGGGALASGTGIGGSSSAGTAAAASLTSTALAMNSKLSANLPVKSP 1019
            |.|  ||||                |.:  ||:..:..:.|:..|....|:...::..::||
 Worm   840 PSTSKASSF----------------TSL--SSTRPSTRSTSIIPTINKKNAFRMSSASIQSP 883

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_610266.1	SFP1	<22..61	CDD:227516
		COG5141	203..>625	CDD:227470	151/439 (34%)
		Bromo_brd1_like	615..712	CDD:99944	31/96 (32%)
		MSCRAMM_ClfA	<1080..1163	CDD:468110
		PWWP_BRPF	1303..1414	CDD:438964
lin-49	NP_501475.1	COG5141	133..548	CDD:227470	159/447 (36%)
		BROMO	508..610	CDD:197636	32/108 (30%)
		TFIIF_alpha	<673..869	CDD:310411	56/231 (24%)