DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Br140 and Mllt10

DIOPT Version :9

Sequence 1:	NP_001286155.1	Gene:	Br140 / 35648	FlyBaseID:	FBgn0033155	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	XP_006497436.2	Gene:	Mllt10 / 17354	MGIID:	1329038	Length:	1101	Species:	Mus musculus

Alignment Length:	1276	Identity:	266/1276 - (20%)
Similarity:	429/1276 - (33%)	Gaps:	413/1276 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 CCICLDGECQNTNVILFCD--MCNLAVHQDCYGVPYIPEGQWLCRRC-LQSPSKPVNCVLCPNAG 347
            ||:|.|......|.:::||  .|::||||.|||:..:|.|.|.||:| .|..:..|.|.|||:..
Mouse    25 CCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKD 89

  Fly   348 GAFKQTDHGQWAHVVCALWIPEVRFANTVFLEPIDSIETIPPARWRLTCYVCKEKG------LGA 406
            ||.|:||:|.||||||||:||||:|||...:||| .::::|..|:..|||:|.|:|      .||
Mouse    90 GALKRTDNGGWAHVVCALYIPEVQFANVSTMEPI-VLQSVPHDRYNKTCYICDEQGRESKAATGA 153

  Fly   407 CIQCHRNSCYAAFHVTCAQQAGLYMTMDTVKDGHNDSSMHVQKFAYCHAHTPADAKLK------- 464
            |:.|:::.|..||||||||.|||      :.:...:.:.:||...||..|.   :|||
Mouse   154 CMTCNKHGCRQAFHVTCAQFAGL------LCEEEGNGADNVQYCGYCKYHF---SKLKKSKRGSN 209

  Fly   465 ----MNVPDF-----------EDTRHKMKEARKALAKKRSTAPVVLIPTIPPDRVQEIATMVTMQ 514
                .::.|.           |..::|.|:..|...||:......|:|::            |:.
Mouse   210 RSYEQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSL------------TVT 262

  Fly   515 RKKEFLDRIIAYWTLKRHYRNGVPLLRRLQSQGNNHGVIQRNGIEGSPDTGELYRQLKYWQCLRQ 579
            .:|.:                        .|..|       |.|.||
Mouse   263 TEKTY------------------------TSTSN-------NSISGS------------------ 278

  Fly   580 DLERARLLCELVRKREKLKVAFVRISEEVVMLQLNPLEAALNKLLDALEAR------------DS 632
                       :::.|.....|...:.:.|       .|..:...|..|||            .|
Mouse   279 -----------LKRLEDTAARFTNANFQEV-------SAHTSSGKDVSEARGSEGKGKKSSAHSS 325

  Fly   633 MQIFREPVDTSEVPDYTDIVKQPMDLGTMRAKLKECQYNSLEQLEADFDLMIQNCLAYNNKDTVF 697
            .|..|:| .....|........|...|:........:.:|...:::.     |:.|::.:.|
Mouse   326 GQRGRKP-GAGRNPGTAVSASSPFPQGSFSGTPGSVKSSSGSSVQSP-----QDFLSFTDSD--- 381

  Fly   698 YRAGIRMRDQAAPLFVQVRKELQRDGLLARSQRYHVDHV--------EAEVEQELRLLLAAPASE 754
                                 |:.|......|......|        ||.| .....|:..|.:
Mouse   382 ---------------------LRSDSYTHTQQPSSTKDVHKGESGSQEAAV-NSFSSLVGHPVT- 423

  Fly   755 GIVQKLLILADKSQVLKNPTYRTKKIKQIRLEISRMRKSLQKARFAARHSSHANQSQSDDEDTLG 819
                        |.|:..|                                   :|..:....||
Mouse   424 ------------STVISQP-----------------------------------KSFDNSPGELG 441

  Fly   820 GSPSKKRTRKRFNSSGVDMEL-------GHDDDDEEEDSDEDSMGEDTVSKDLLNSTQTPPCSPI 877
            .|.......||..:||::.|.       |:..........:.:..::.||.  |:.:...|.|.:
Mouse   442 SSSLPTAGYKRAQTSGIEEEAVKEKKRKGNKQSKHGPGRPKGNKNQENVSH--LSVSSASPTSSV 504

  Fly   878 KSLNNSSSPVGINRRTAILLTRKAQAALKRPSEPLTTPVKEEQHNSQSSNTQSTSG--------- 933
            .|...|.:...:.:...:|.....| :|...|.|:.:.:..:..:..:..|.:.|.
Mouse   505 ASAAGSVTSSSLQKSPTLLRNGSLQ-SLSVGSSPVGSEISMQYRHDGACPTTTFSELLNAIHNGI 568

  Fly   934 -SSSSVTTAATAASSGAGTLNHVLSSAPPTASSFALTQNNSSGGGALASGTGIGGSSSAGTAAAA 997
             :|:.|..:.....||:|:...|.||..|..||..|.|..:....|.:|.|....::.|.|.:.:
Mouse   569 YNSNDVAVSFPNVVSGSGSSTPVSSSHIPQQSSGHLQQVGALSPSAASSVTPAAATTQANTVSGS 633

  Fly   998 SLTSTALAM-NSKLSANLPVKSPKRPGRYRRVPEVRHSSSMSPKKSPNPAVTVSQALPMPETLPF 1061
            ||:.....| .|:|:.|                             |:.||.::|:
Mouse   634 SLSQAPAHMYGSRLNQN-----------------------------PSMAVLIAQS--------- 660

  Fly  1062 ERIPDSFRVYR--ANNQRDVSDSDDAPSQSSSPCSSCSDFSMSGSCSDFDSDEASEGDADGDPDR 1124
                :|.:..:  .:|.|.:.....:|..|.||.|..|:..:.       .|:.|....:..|..
Mouse   661 ----ESSQTDQDLGDNARSLGGRGSSPRGSLSPRSPVSNLQLR-------YDQPSNSSLETVPPV 714

  Fly  1125 DGG------RSRSEERDSTSQEGTT-DAMDMQHASLNNVQGNNGNMAISSSSGGSGGSSSEDDEL 1182
            ...      |..||.:....::||. |.:.|. .||:.:|                   .|:..|
Mouse   715 AASIEQLLERQWSEGQQFLLEQGTPGDILGML-KSLHQLQ-------------------VENRRL 759

  Fly  1183 EE--RPLSARQNKPMKVGTR-GTPTPTTMARAVALSAGRGRGKRRSNLSES------TSSTATPP 1238
            ||  :.|:|::.:...:..: ..|.|..                .:|.|.|      |:.||.||
Mouse   760 EEQIKNLTAKKERLQLLNAQLSVPFPAI----------------TTNPSPSHQMHTYTAQTAPPP 808

  Fly  1239 PLRRAGKLRSATPNASPLVNNIKARRNTTAAGSAPLTNNNRSKHSEDSASSERHNNHSHGQKPAL 1303
            .        |...:.||.:.|.....|:....:..||::.:|    .|:||........||.||.
Mouse   809 D--------SLNSSKSPHIGNSFLPDNSLPVLNQDLTSSGQS----TSSSSALSTPPPAGQSPAQ 861

  Fly  1304 EPLQL----------VWAKCRGYPWYPALILDPKTPKGFV----------------YNGV---PL 1339
            :...:          |.|...|.....:.|.......|.:                .|||   |:
Mouse   862 QSSGVSGVQQVNGVTVGALASGMQTVTSTIPAVSAVGGIIGALPGNQLAINGIVGALNGVIQTPV 926

  Fly  1340 -----PAPPTDVLALRKNCLDEIVFLVLFFDVKRTWQWLPANKLDILGI--DKQLDQ-------Q 1390
                 |||.|.. ::..|....:....|            .|....||:  |:|...       |
Mouse   927 TISQNPAPLTHT-SVPPNAAHPMPAAAL------------TNSASGLGLLSDQQRQMFIQQQQFQ 978

  Fly  1391 KLVESRK--PAERKAVKKAYQDALHYQSQVSDLEGQGPDPI 1429
            :|:.|::  |.:.:|.........|:..::..|:..||..|
Mouse   979 QLLNSQQLTPEQHQAFLYQLMQQQHHPPELQQLQLPGPTQI 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_001286155.1	EPL1	<192..264	CDD:287484
		PHD_BRPF	283..336	CDD:277047	22/52 (42%)
		ePHD_BRPF	340..456	CDD:277140	56/121 (46%)
		Bromo_brd1_like	615..712	CDD:99944	16/108 (15%)
		BR140_related	1303..1414	CDD:99900	25/155 (16%)
Mllt10	XP_006497436.2	PHD_AF10_AF17	24..71	CDD:277049	20/45 (44%)
Mllt10	XP_006497436.2	ePHD_AF10	78..206	CDD:277178	61/137 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840