DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Br140 and phf14

DIOPT Version :9

Sequence 1:	NP_001286155.1	Gene:	Br140 / 35648	FlyBaseID:	FBgn0033155	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	XP_012819844.1	Gene:	phf14 / 100216242	XenbaseID:	XB-GENE-992415	Length:	968	Species:	Xenopus tropicalis

Alignment Length:	887	Identity:	194/887 - (21%)
Similarity:	301/887 - (33%)	Gaps:	294/887 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 EELDGEVE---YDV---------DEE------------DSAWLEHMNEERQRLGLNAVGIDTMEL 256
            ||.||..|   |..         |||            :||..|.:..:...|..:....|:  |
Frog   190 EEEDGSDEGSNYQAGHDNCSSSSDEEGKKKKKIKFPSRNSADDEELTNDSLTLSQSKSNEDS--L 252

  Fly   257 LMDRLEKESHFQAAANGTPTGVEVDDDAVCCICLDGECQNTNVILFCDMCNLAVHQDCYGVPYIP 321
            ::::.||.|           ..:||...:||:||....::.:.|:.||.|.:.||:.||||
Frog   253 ILEKSEKWS-----------SQKVDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGV---- 302

  Fly   322 EGQ---------------WLCR--RCLQSPSKPVNCVLCPNAGGAFKQTDHGQWAHVVCALWIPE 369
            :|:               |.|.  :|..|||    |.||||..|.||:||.|:|.|:||||::|.
Frog   303 DGESDSIMSSASENSTEPWFCDACKCGVSPS----CELCPNQDGIFKETDAGRWVHIVCALYVPG 363

  Fly   370 VRFANTVFLEPIDSIETIPPARWRLTCYVCKEKGL---GACIQCHRNSCYAAFHVTCAQQAGLYM 431
            |.|.:...|.|:...|..........|..|::...   |.||.|....|.:.|||||||:.||
Frog   364 VAFGDIDKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGVCISCDAGMCRSYFHVTCAQKEGL-- 426

  Fly   432 TMDTVKDGHNDSSMHVQKFAYCHAHTPA-DAKLK-MNVPDFED-TRHKMKEARKALAKKRSTAPV 493
                :.:...:..:....||||..|... |.|.| .|....:. .:..:||..|.||
Frog   427 ----LSEAAAEEDIADPFFAYCKQHADRFDRKWKRKNYLALQSYCKMSLKEREKQLA-------- 479

  Fly   494 VLIPTIPPDRVQEIATMVTMQRKKEFLDRII--AYWT----LKRHYRNGVPLLRRLQSQGNNHGV 552
                   |:....|:|.:...|.|..|.|..  ..|.    |.|...:....:|:|..:....|:
Frog   480 -------PEAQARISTRLQQYRVKSELARSTRPQAWVPREKLPRPLTSSASAIRKLMRKAELMGI 537

  Fly   553 I----------QRNGIEG---------SPDTGELY--RQLKYWQCLRQDLERARLLCELVRKREK 596
            .          ..:.::|         |.|....|  |.::..|......|:..:..:|..::||
Frog   538 STDIFPVDNSDTSSSVDGRRKHKQPALSADFVNYYLERNMRMMQLQENMTEQKNIKDKLENEQEK 602

  Fly   597 LKVAFVRISEEVVMLQ-LN--------PLEAALNKLLDALEARDSMQIFREPVD----------- 641
            |.:.:.::.|.:..|| :|        .|...::|:  |.:..:...|.|.|.:
Frog   603 LHIEYNKLCETLDDLQNMNSSLRNEGQTLWIMMSKI--AGQKTNIPAILRSPKERKPSKREGGTQ 665

  Fly   642 -TSEVPD--YT----------------DIVKQPMDLGTMRAKL--------------KECQYNSL 673
             ||.:|.  |:                |..|....||.:...|              .||.....
Frog   666 KTSPLPAVLYSCGICKRSNDQHLLLLCDTCKLHYHLGCLDPPLTRMPKKTKNSYWQCSECDQAGS 730

  Fly   674 EQLEADFDLMIQNCLAYNNKDTVFYRAGIRMRDQAAPLFVQVRKELQRDGLLARSQRYHVDHVEA 738
            ..:||||.:                                   |...|| ..||:|
Frog   731 SDIEADFAM-----------------------------------ETLPDG-TKRSRR-------- 751

  Fly   739 EVEQELRLLLAAPASEGIVQKLLILADKSQVLKNPTYRTKKIKQIRLEISRMRKSLQKARFAARH 803
            ::::.::.:                   ||.:...|.:|.            .:|.||..:..|.
Frog   752 QIKEPIKFV-------------------SQDMPQDTKKTP------------LRSTQKHCYRGRR 785

  Fly   804 -SSH----------------ANQSQSDDEDTLGGSP-SKKRTRKRFNSSGVDME-LGHDDDDEEE 849
             |||                :.||:...|.|..|.. |:.|.:||..|..::.| |......|..
Frog   786 KSSHFVTSDDLTSEKQSLDSSRQSELQHEHTQRGDVLSRTRGQKRRRSFMLEEEKLEERTPRERR 850

  Fly   850 DSDEDSMGEDTVSKDLLNSTQTPPCSPIKSLNNSSSPVGINRRTAILLTRKAQAALKRPSEPLTT 914
            .....::.:...|.||...     |:..|...::.:           |.|..:..|......|..
Frog   851 RRQPMALHKKPKSDDLRTE-----CAVCKGTGDNEN-----------LVRCDECTLCYHFGCLDP 899

  Fly   915 PVKE-----------EQHNSQSSNT--QSTSGSSSSVTTAAT 943
            |:|:           ::.:|.||..  |:.:|||.|..|..|
Frog   900 PLKKSPKQTGYGWICQECDSTSSKEVYQNAAGSSESAATRKT 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_001286155.1	EPL1	<192..264	CDD:287484	16/71 (23%)
		PHD_BRPF	283..336	CDD:277047	20/69 (29%)
		ePHD_BRPF	340..456	CDD:277140	43/118 (36%)
		Bromo_brd1_like	615..712	CDD:99944	21/140 (15%)
		BR140_related	1303..1414	CDD:99900
phf14	XP_012819844.1	PHD1_PHF14	270..326	CDD:277036	17/59 (29%)
		ePHD_PHF14	334..447	CDD:277144	43/118 (36%)
		PHD2_PHF14	676..725	CDD:277037	5/48 (10%)
		PHD3_PHF14	869..917	CDD:277038	8/63 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D566217at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920