Protein Alignment Br140 and brpf3a

DIOPT Version :10

• Sequence 1: NP_610266.1
• Gene: Br140 / 35648
• FlyBaseID: FBgn0033155
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: XP_021335519.1
• Gene: brpf3a / 100149254
• ZFINID: ZDB-GENE-130530-730
• Length: 1214
• Species: Danio rerio
• Alignment Length: 1486
• Identity: 481/1486 - (32%)
• Similarity: 679/1486 - (45%)
• Gaps: 403/1486 - (27%)

  Fly    63 RKKARSRSGG-----------HHSTPRPHKD------HPTPGGGGAEARNGCSSASAGGGSASGV 110
            ::.|:||:||           ....|..|.|      .|:|          |
Zfish     6 KRVAQSRAGGFGRGLVREEDQDQVGPSSHVDMDALLCPPSP----------C------------- 47

  Fly   111 SARQYANPESLVSYNEEEATVTFNLDGKSVRLGIDDALPLVEDEEFAALVARGCILNADAPPLEE 175
             ...::.....::|.:.:..|...|:|:..|:.|.|.|.:|.::|..|.....|..|      :|
Zfish    48 -RLNFSPTRDTLTYAQAQRMVEIELEGRLHRINICDQLSVVTEDEMLAQDLTECNSN------KE 105

  Fly   176 NAPW----------------------------------ARVQVPVAR--VAEIPDYRVSDAPPRP 204
            |:..                                  |.:|.|:.:  ..::.::.||||||.|
Zfish   106 NSEQRQGNKQAASKSKKKDGKHTAKKKSGGQYGLQGQVAHLQAPLPKPTFRKLDNFTVSDAPPLP 170

  Fly   205 LAYYRFIEKSLEELDGEVEYDVDEEDSAWLEHMNEERQRLGLNAVGIDTMELLMDRLEK----ES 265
            :||||::|||.||||.|.|||:||||.||||.:|::|...|..:|..||.|||:||||:    ||
Zfish   171 VAYYRYMEKSGEELDNEAEYDMDEEDMAWLEMVNQKRVSDGHASVPPDTFELLIDRLERESILES 235

  Fly   266 HFQAAANGTPTGVEVDDDAVCCICLDGECQNTNVILFCDMCNLAVHQDCYGVPYIPEGQWLCRRC 330
            ..||.:..|     :|:||.||:|||.||.|:|||||||:|||||||:|||||||||||||||||
Zfish   236 RSQALSQST-----IDEDAYCCVCLDDECLNSNVILFCDICNLAVHQECYGVPYIPEGQWLCRRC 295

  Fly   331 LQSPSKPVNCVLCPNAGGAFKQTDHGQWAHVVCALWIPEVRFANTVFLEPIDSIETIPPARWRLT 395
            |||||:||:||||||.|||||||..|.||||:||:|||||.|||||||||::.::.||||||:||
Zfish   296 LQSPSRPVDCVLCPNRGGAFKQTSDGSWAHVICAIWIPEVCFANTVFLEPVEGVKNIPPARWKLT 360

  Fly   396 CYVCKEKGLGACIQCHRNSCYAAFHVTCAQQAGLYMTMDTVKD-GHNDSSMHVQKFAYCHAHTPA 459
            ||:||:||.||.||||:.:||.||||||||:|||||.:|.|:: |.|.::..|:|.|||..|:|.
Zfish   361 CYLCKQKGRGASIQCHKANCYRAFHVTCAQRAGLYMKIDPVRETGTNGTTFTVKKTAYCENHSPP 425

  Fly   460 DAKLKMNVPDFEDT--------------------------RHKMKEARKALAKKRS-------TA 491
            ..    ....:||.                          |.|...|::...:|.|       ..
Zfish   426 GT----GTEGYEDNGLVGGRGNRGQRSYTLGPPLQQNQNGRKKGSAAQQKKTQKNSGGGSRKTGV 486

  Fly   492 PVVLIPTIPPDRVQEIATMVTMQRKKEFLDRIIAYWTLKRHYRNGVPLLRRLQSQGNNHGVIQRN 556
            |::|:|.||..|:.:|.|.|:::||.:|:.|:..||.||||.||||||:|||.|    |...|::
Zfish   487 PLLLVPQIPSFRLNKICTGVSVERKNQFMQRLHNYWLLKRHSRNGVPLIRRLHS----HLQAQKS 547

  Fly   557 GIEGSPDT--GELYRQLKYWQCLRQDLERARLLCELVRKREKLKVAFVRISEEVVMLQLNPLEAA 619
            . :..||.  ..:..:|||||.||||||:||||.||:||||:||...:::.:..:.|||.|....
Zfish   548 E-QREPDAKLQAVREELKYWQKLRQDLEKARLLIELIRKRERLKREQMKLQQAALELQLTPALVF 611

  Fly   620 LNKLLDALEARDSMQIFREPVDTSEVPDYTDIVKQPMDLGTMRAKLKECQYNSLEQLEADFDLMI 684
            |...|:.|:.:|:..||..||:..|||||.:.|..|||..||..||:..:|:|:..||.||:||:
Zfish   612 LRATLEQLKEKDTDHIFTTPVNLKEVPDYLEFVTVPMDFSTMHDKLEAHKYSSVADLENDFNLMV 676

  Fly   685 QNCLAYNNKDTVFYRAGIRMRDQAAPLFVQVRKELQRDGLLARSQRYHV--------------DH 735
            .|||.||:.||||::|.:::|:....:....:.:....| |..|...|:              |.
Zfish   677 SNCLRYNSNDTVFHKAAMQLREVGGAILRHAQHQALSIG-LDPSTGMHLPDKPIPHNTTVSWCDE 740

  Fly   736 VEAEVEQELRLLLAAPASEGIVQKLLILADKSQVLKNPTYRTKKIKQIRLEISRMRKSLQKARFA 800
            |:..::.:.|:.:.|   |..::.||...|....::....|||:::.:|.||:.:|..:
Zfish   741 VDMLLDPDNRVHMCA---EDQLKTLLDKLDLVASMRTSGGRTKRMRLLRREINSLRHKI------ 796

  Fly   801 ARHSSHANQSQSDDEDTLGGSPSKKRTRKRFNSSGVDMELGHDDDDEEEDSDEDSMGEDTVSKDL 865
                ||    |..:...|.|...:::::                 |.:.:...|.:..:...|..
Zfish   797 ----SH----QDRNSRLLNGKIREEKSK-----------------DAKSEKKMDYITSEDPKKSA 836

  Fly   866 LNSTQTPPCSPIKSLNNSSSPVGINRRTAILLTRKAQAALKRPSEPL--------TTPVKEEQHN 922
            ....|.|.| |..|.....:|                     |:.||        |||.   |.|
Zfish   837 SQKAQEPAC-PASSPLPGDAP---------------------PNPPLFCLETGRTTTPA---QSN 876

  Fly   923 SQSSNTQSTSGSSSSVTTAATAASSGAGTLNHVLSSAPPTASSFALTQNNSS-GGGALASGTGIG 986
            ...|..|...|...|:..            ||  :..|....:|...:|:|| ....:.|.....
Zfish   877 KPGSRKQRAKGKDRSLRE------------NH--NQTPKEDENFHTKENDSSPQEDRVCSAKNQS 927

  Fly   987 GSSSAGTAAAASLTSTALAMNSKLSANLPVKSPKRPGRYRRVPEVRHSSSMSPKKSPNPAVTVSQ 1051
            .|...|.....|:........::.:.:.||..|....:.:.......::......:|.|   ||
Zfish   928 DSPKIGVGRRTSILFKKAKNGARPTKDKPVLLPNGVSKAQNGASQEQNTQAKAPSTPKP---VS- 988

  Fly  1052 ALPMPETLPFERIPDSFRVYRANNQRDVSDSDDAPSQSSSPCSSCSDFSMSGSCSDFDSDEASEG 1116
              |.|..|                             .|...|:|||               .||
Zfish   989 --PSPHQL-----------------------------RSRGLSTCSD---------------GEG 1007

  Fly  1117 -DADGDPDRDGGRSRSEERDSTSQEGTTDAMDMQHASLNNVQGNNGNMAISSSSGGSGGSSSEDD 1180
             .|:..|:.:|                         ..|.::.:|||.:.|.:|
Zfish  1008 MKANSLPEENG-------------------------LTNGLKRHNGNSSDSENS----------- 1036

  Fly  1181 ELEERPLSARQNKPMKVGTRGTPT-PTTMARAVALSAGRGRGKRRSNLSESTSSTATPPPLRRAG 1244
                                 ||. ||                      .|:|     ||.|..|
Zfish  1037 ---------------------TPAFPT----------------------HSSS-----PPKRSRG 1053

  Fly  1245 KLRSATPNASPLVNNIKARRNTTAAGSAPLTNNNRSKHSEDSASSERHNNHSHGQKPALEPLQLV 1309
            |                     .|....|:   :..|:...:.:||...|...     :|||.||
Zfish  1054 K---------------------PALSKVPV---DEEKNEVTNTNSEASQNDGE-----MEPLTLV 1089

  Fly  1310 WAKCRGYPWYPALILDPKTP-KGFVYNGVPLPAPPTDVLAL---RKNCLDEIVFLVLFFDVKRTW 1370
            ||||||||.|||:|:|||.| :|.::||:|:|.||||||.|   |:...:|.:|||||||.||||
Zfish  1090 WAKCRGYPSYPAMIVDPKMPQEGILHNGIPIPVPPTDVLDLGKRRQEESEEKLFLVLFFDTKRTW 1154

  Fly  1371 QWLPANKLDILGIDKQLDQQKLVESRKPAERKAVKKAYQDALHYQSQVSDLEGQGP 1426
            ||||.:||..:|||..:|:.:|:|.:||..||:|..||..|:.:.|.|.:.....|
Zfish  1155 QWLPQDKLHHMGIDDTVDRLRLMEGKKPNVRKSVHTAYDRAMTHLSHVQENSSFNP 1210

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_610266.1	SFP1	<22..61	CDD:227516
		COG5141	203..>625	CDD:227470	239/461 (52%)
		Bromo_brd1_like	615..712	CDD:99944	41/96 (43%)
		MSCRAMM_ClfA	<1080..1163	CDD:468110	13/83 (16%)
		PWWP_BRPF	1303..1414	CDD:438964	66/114 (58%)
brpf3a	XP_021335519.1	COG5141	125..654	CDD:227470	265/542 (49%)
		ePHD_BRPF3	305..422	CDD:277173	78/116 (67%)
		Bromodomain	607..704	CDD:445827	41/96 (43%)
		PWWP	1083..1200	CDD:470613	66/116 (57%)