Protein Alignment Br140 and brpf1

DIOPT Version :10

• Sequence 1: NP_610266.1
• Gene: Br140 / 35648
• FlyBaseID: FBgn0033155
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: XP_012815976.1
• Gene: brpf1 / 100127652
• XenbaseID: XB-GENE-995817
• Length: 1273
• Species: Xenopus tropicalis
• Alignment Length: 1589
• Identity: 557/1589 - (35%)
• Similarity: 741/1589 - (46%)
• Gaps: 486/1589 - (30%)

  Fly     1 MGLDFDAVEYCKGVKTQQSQPPFACPVRGCDRSYKTIMGLQYHLMKYDHDNPQPLTPVLTPSRKK 65
            ||:|||...:|..::.  ::||:.|||..|.:.||:..|::|||..|||||| ||.. .||.||
 Frog     2 MGVDFDVKTFCHNLRA--TKPPYECPVETCRKIYKSYSGIEYHLYHYDHDNP-PLQQ-QTPIRK- 61

  Fly    66 ARSRSGGHHSTPR-PHKDHPTPGGGGAEARNGCSSASAGGGSASGVSARQYANPESLVSYNEEEA 129
              |:..|.|  || .:|..||                  ....|....|:      :::|.:.:.
 Frog    62 --SKKKGRH--PRSANKQSPT------------------NSEVSQSPTRE------VMTYAQAQR 98

  Fly   130 TVTFNLDGKSVRLGIDDALPLVEDEEFAALVARGCILNADAPPLE--------EN---------- 176
            .|...|.|:..|:.|.|.|.:|.::              |.||.|        ||
 Frog    99 LVEVELHGRVHRISIFDNLDVVSED--------------DDPPEETPENGSNKENNDTPATTPKS 149

  Fly   177 --------------------APWARVQVP--VARVAEIPDYRVSDAPPRPLAYYRFIEKSLEELD 219
                                ...|..::|  |.|..|:..   .||||||.:|||:||||.||||
 Frog   150 GKHKNKDKRKDSNHHHHHSATAGAATKLPEVVYRELELDS---PDAPPRPSSYYRYIEKSAEELD 211

  Fly   220 GEVEYDVDEEDSAWLEHMNEERQRLGLNAVGIDTMELLMDRLEKESHFQAAANGTPTGVEVDDDA 284
            .|||||:||||..||:.||:.|:..|:|.:..:..|.|||||||||:|::...|.|..: :|:||
 Frog   212 EEVEYDMDEEDYIWLDIMNDRRKNDGVNHIPQEIFEYLMDRLEKESYFESHNKGDPNSL-IDEDA 275

  Fly   285 VCCICLDGECQNTNVILFCDMCNLAVHQDCYGVPYIPEGQWLCRRCLQSPSKPVNCVLCPNAGGA 349
            |||||.||||||:|||||||||||||||:||||||||||||||||||||||:.|:|.||||.|||
 Frog   276 VCCICNDGECQNSNVILFCDMCNLAVHQECYGVPYIPEGQWLCRRCLQSPSRAVDCALCPNKGGA 340

  Fly   350 FKQTDHGQWAHVVCALWIPEVRFANTVFLEPIDSIETIPPARWRLTCYVCKEKGLGACIQCHRNS 414
            |||||.|:|||||||||||||.||||||||||||||.||||||:||||:||::|.|||||||:.:
 Frog   341 FKQTDDGRWAHVVCALWIPEVCFANTVFLEPIDSIEHIPPARWKLTCYICKQRGSGACIQCHKAN 405

  Fly   415 CYAAFHVTCAQQAGLYMTMDTVKD-GHNDSSMHVQKFAYCHAHTPADAKLKM-----------NV 467
            ||.||||||||||||||.|:.|:: |.|.:|..|:|.|||..|||..:..|:           :.
 Frog   406 CYTAFHVTCAQQAGLYMKMEPVRETGANGTSFSVRKTAYCDIHTPPGSVCKLPALSHSEGEEEDD 470

  Fly   468 PDFED---------------TRHKMKEARKALAKKRSTAPVVLIPTIPPDRVQEIATMVTMQRKK 517
            .:.||               :|.|||:|||.||:||:.||||.:|.|||.|:.:|...:|:|||.
 Frog   471 EEEEDGKGWSSEKVKKAKAKSRIKMKKARKILAEKRAAAPVVSVPCIPPHRLSKITNRLTIQRKS 535

  Fly   518 EFLDRIIAYWTLKRHYRNGVPLLRRLQSQGNNHGVIQRN-------------------------- 556
            :|:.|:.:||||||..|||||||||||:    |...|||
 Frog   536 QFMQRLHSYWTLKRQSRNGVPLLRRLQT----HLQSQRNCDQKASSSESETTYSACLSAFGTVQE 596

  Fly   557 ---GIEGSPDT--------------GE-------------LYRQLKYWQCLRQDLERARLLCELV 591
               .|..|.||              |:             |..|||.||.||.||||||||.||:
 Frog   597 MKWRIPISDDTPGHLGTIAISNEEPGDQANKNDPTDKNWVLKEQLKSWQRLRHDLERARLLVELI 661

  Fly   592 RKREKLKVAFVRISEEVVMLQLNPLEAALNKLLDALEARDSMQIFREPVDTS------EVPDYTD 650
            |||||||...:::.:..:.:||.|....|.|.|:.|:.:|:..||.|||..|      |||||.:
 Frog   662 RKREKLKRETIKVQQMALEMQLTPFLILLRKTLELLQEKDTSNIFTEPVPLSEVTEIYEVPDYLE 726

  Fly   651 IVKQPMDLGTMRAKLKECQYNSLEQLEADFDLMIQNCLAYNNKDTVFYRAGIRMRDQAAPLFVQV 715
            .||:|||..||:..|:..:|.:.:|.|.||:|::.||:.||.|||:||||..|:|:|.|.|..|.
 Frog   727 HVKKPMDFQTMKRNLEAFRYQNFDQFEEDFNLIVNNCIKYNAKDTIFYRAASRLREQGAALLRQA 791

  Fly   716 RKELQRDGL----------------LARS------QRYHV--DHVEAEVEQELRLLLAAPASEGI 756
            ||:.::.|:                :.|.      :|.|:  ...:..:|::|::.||.
 Frog   792 RKQAEKIGIDFETGMHIHPVITGNEIGRHGRENDFERAHLSDSRKQLPLEEQLKVQLAR------ 850

  Fly   757 VQKLLILADKSQVLKNPTYRTKKIKQIRLEISRMRKSLQKARFAARHSSHANQSQSDDEDTLGGS 821
                   .|:....|....|.::.|.||.||:.:|:.:          .:..:|:.|     |||
 Frog   851 -------LDEVNASKQSIGRARRAKMIRKEITSIRRKM----------VYQQESRRD-----GGS 893

  Fly   822 PSKKRTRKRFNSSGVDMELGHDDDDEEEDSDEDSMGEDTVSKDLLNSTQTPPCSPIKSLNNSSSP 886
                   :|.:|:|......|  ...|:|...||..|::.|::....     ..|..|..|:..
 Frog   894 -------ERHSSAGRGALPLH--GPSEKDGQTDSAAEESSSQETGKG-----LGPNTSSTNAHE- 943

  Fly   887 VGINRRTAILLTRKAQAALKRPSEPLTTPVKEEQHNSQSSNTQSTSGSSSSVTTAATAASSGAGT 951
              :.|||::|.::|.......|..|...|        ::.:.|.:||..||.......:.:|...
 Frog   944 --VGRRTSVLFSKKNPKTAGPPKRPGRPP--------KNRDNQLSSGQISSPIGPPQLSVTGGSQ 998

  Fly   952 LNHVLSSAPPTASSFALTQNNSSGGGALASGTGIGGSSSAGTAAAASLTSTALAMNSKLSANLPV 1016
            ....:.|..||:||.:                   .|.|..:|...||             :||.
 Frog   999 RRKRVRSPRPTSSSDS-------------------DSDSEKSAEEPSL-------------DLPT 1031

  Fly  1017 KSPKRPGRYRRVPEVRHSSSMSPKKSPNPAVTVSQALPMPETLPFERIPDSFRVYR--ANNQRDV 1079
            ..              .|||.                        :::..||.|||  .|..|..
 Frog  1032 NG--------------FSSST------------------------QQVKKSFLVYRTDCNLPRSS 1058

  Fly  1080 SDSDDAPSQSSSPCSSCSDFSMSGSCSDFDSDEASEGDADGDPDRDGGRSRSEERDSTSQEGTTD 1144
            |||:.:.:.|||..                ||..|.     .|.:.|....|..||:.:.
 Frog  1059 SDSESSTTSSSSAA----------------SDRTST-----TPSKQGRGKPSFSRDNFAD----- 1097

  Fly  1145 AMDMQHASLNNVQGNNGNMAISSSSGGSGGSSSEDDELEERPLSARQNKPMKVGTRGTPTPTTMA 1209
                                          .||||       .|..:|:...||
 Frog  1098 ------------------------------YSSED-------TSGTENESYSVG----------- 1114

  Fly  1210 RAVALSAGR-GRGKRRSNLSESTSSTATPPPLRRAGKLRSATPNASPLVNNIKARRNTTAAGSAP 1273
                   || |.|..|..|..           |.||.|
 Frog  1115 -------GRVGHGLVRKGLES-----------RGAGWL--------------------------- 1134

  Fly  1274 LTNNNRSKHSEDSASSERHNNHSHGQKPALEPLQLVWAKCRGYPWYPALILDPKTPK-GFVYNGV 1337
                     |||..|             .||.|.||||||||||.|||||:|||.|: |..::||
 Frog  1135 ---------SEDEDS-------------PLEALDLVWAKCRGYPSYPALIIDPKMPREGVFHHGV 1177

  Fly  1338 PLPAPPTDVLALRKNCLDEI---VFLVLFFDVKRTWQWLPANKLDILGIDKQLDQQKLVESRKPA 1399
            |:|.||.|||.|.:....|.   ::||||||.||||||||..||..||::::||::|::|.||..
 Frog  1178 PIPVPPVDVLKLGEQMAQEAQEHLYLVLFFDNKRTWQWLPRTKLVPLGMNRELDKEKMLEGRKSN 1242

  Fly  1400 ERKAVKKAYQDALHYQSQVSDLEGQGPDP 1428
            .||:|:.||..|:.::::|     || ||
 Frog  1243 IRKSVQIAYDRAMQHRNKV-----QG-DP 1265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_610266.1	SFP1	<22..61	CDD:227516	19/38 (50%)
		COG5141	203..>625	CDD:227470	270/504 (54%)
		Bromo_brd1_like	615..712	CDD:99944	46/102 (45%)
		MSCRAMM_ClfA	<1080..1163	CDD:468110	14/82 (17%)
		PWWP_BRPF	1303..1414	CDD:438964	64/114 (56%)
brpf1	XP_012815976.1	SFP1	<21..53	CDD:227516	17/32 (53%)
		COG5141	180..>558	CDD:227470	232/381 (61%)
		ePHD_BRPF1	331..451	CDD:277171	89/119 (75%)
		Bromodomain	685..788	CDD:445827	46/102 (45%)
		PWWP_BRPF1	1142..1261	CDD:438984	64/118 (54%)