Protein Alignment Br140 and brd1b

DIOPT Version :10

• Sequence 1: NP_610266.1
• Gene: Br140 / 35648
• FlyBaseID: FBgn0033155
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: XP_005163199.1
• Gene: brd1b / 100009661
• ZFINID: ZDB-GENE-070209-98
• Length: 1168
• Species: Danio rerio
• Alignment Length: 1398
• Identity: 468/1398 - (33%)
• Similarity: 653/1398 - (46%)
• Gaps: 351/1398 - (25%)

  Fly   117 NPESLVSYNEEEATVTFNLDGKSVRLGIDDALPLVEDEEFAALVARGC----------------- 164
            |.|:| :|.|.:..|...:||:..||.|.|.|.:::.::..|.....|
Zfish    25 NRETL-TYAEAQRMVELEIDGRVHRLSIYDKLDVIDSDDPLAQEISECTSNKENTEKPQQVLVRS 88

  Fly   165 -------------ILNADAPPLEENAPWARVQVPVARVAEIPDYRVSDAPPRPLAYYRFIEKSLE 216
                         :.|....|.:     .|:..|..|:.|   |.:...|.||..||.::||:|:
Zfish    89 VRLKNNQQKKSAALTNVQGSPAQ-----GRLPEPKIRMVE---YNLPAVPRRPSVYYTYMEKTLD 145

  Fly   217 ELDGEVEYDVDEEDSAWLEHMNEERQRLGLNAVGIDTMELLMDRLEKESHFQAAANGTPTGVEVD 281
            |||.|||||:||||.||||.|||:|:..|.:.|..:..|.||||.||||.|.:.|.|.|..: :|
Zfish   146 ELDEEVEYDMDEEDYAWLEMMNEKRKSDGHSQVSQNVFEFLMDRFEKESFFDSQAQGEPQSL-ID 209

  Fly   282 DDAVCCICLDGECQNTNVILFCDMCNLAVHQDCYGVPYIPEGQWLCRRCLQSPSKPVNCVLCPNA 346
            :|||||||:||||||:|.|||||||||||||:|||||:||||:||||.||.|||:...|:.|||.
Zfish   210 EDAVCCICMDGECQNSNAILFCDMCNLAVHQECYGVPHIPEGRWLCRHCLNSPSQLAECIFCPNK 274

  Fly   347 GGAFKQTDHGQWAHVVCALWIPEVRFANTVFLEPIDSIETIPPARWRLTCYVCKEKGLGACIQCH 411
            |||.|:||..:|.|||||:|:|||.|.||:|:||||.:..||||||:||||:||:||:||||||.
Zfish   275 GGALKRTDDDRWGHVVCAIWVPEVGFTNTLFIEPIDGVANIPPARWKLTCYLCKKKGVGACIQCS 339

  Fly   412 RNSCYAAFHVTCAQQAGLYMTMDTVKD--GHNDSSMHVQKFAYCHAHTP-----------ADAKL 463
            :.:||.||||:|||:|||||.|:.||:  ....::..|:|.|||..|||           .|:|.
Zfish   340 KANCYTAFHVSCAQKAGLYMKMEPVKEVTESGGTTFSVKKTAYCCPHTPNGFVRRPLTIYDDSKS 404

  Fly   464 KMNVPDFEDTRHKMKEARKALAKKRSTAPVVLIPT-----IPPDRVQEIATMVTMQRKKEFLDRI 523
            |..|......|.::|..:|...||..:.|..::||     |.|.....|...|::|:|:.|::|:
Zfish   405 KNGVCQKAAHRERVKGCQKKKNKKPESEPDTVVPTVSGPSITPKSFNTILNQVSVQKKRMFVERV 469

  Fly   524 IAYWTLKRHYRNGVPLLRRLQSQGNNHGVIQRNGIEGSP---DTGELYRQLKYWQCLRQDLERAR 585
            ::||.|||..||||||:||||:     .:..:...|..|   |...|..|||....||.||||||
Zfish   470 LSYWMLKRQSRNGVPLIRRLQT-----AIQTQKDPEDDPCVDDHQTLTDQLKDLHRLRHDLERAR 529

  Fly   586 LLCELVRKREKLKVAFVRISEEVVMLQLNPLEAALNKLLDALEARDSMQIFREPVDTSEVPDYTD 650
            ||.||:|||||||...:::.:.|:.:||.|....|...||.|:.:|..:||.:||..:|||||.|
Zfish   530 LLLELIRKREKLKREEMKLQQSVLEMQLTPFPIILRVALDQLQEKDQAKIFAQPVSVTEVPDYLD 594

  Fly   651 IVKQPMDLGTMRAKLKECQYNSLEQLEADFDLMIQNCLAYNNKDTVFYRAGIRMRDQAAPLFVQV 715
            .:|.|||..|||.::...:|.||::.|.||:|:|.|||.||.|||.|||||:||||....:..:.
Zfish   595 HIKHPMDFSTMRKRIDGHEYQSLDEFEEDFNLIINNCLKYNAKDTYFYRAGVRMRDHGGVILRRT 659

  Fly   716 RKELQRDGL---------------LARSQRYH-VDHV-----EAEVEQELRLLLAAPASEGIVQK 759
            |:|.:|.|.               |..|..:| ||.|     .|.:.::.:|           :|
Zfish   660 RRETERIGFEFPSGIHLPEPPKLELPPSFTWHDVDRVLNPANRAHMSKDEQL-----------KK 713

  Fly   760 LLILADKSQVLKNPTYRTKKIKQIRLEISRMRKSL-QKARFAARHSSHANQSQSDDEDTLGGSPS 823
            ||.:.|.:..:|:...|:|::|.::..|..:|..: ||..                      .||
Zfish   714 LLEMLDLTFAMKSCPSRSKRLKLLKKTIGDVRMDMGQKTE----------------------PPS 756

  Fly   824 KKRTRKRFNSSGVDMELGHDDDDEEEDS----DEDSMGEDTVSKDLLNSTQTPPCSPIKSLNNSS 884
                            |..::..|||.:    .::..|:.::...|      .|...:..|.||.
Zfish   757 ----------------LEQNNTKEEEKAPLILPQEEEGDKSLPPKL------EPSDSVPLLKNSD 799

  Fly   885 SPVGINRRTAILLTRKAQAALKRPSEPLTTPVKEEQHNSQSSNTQSTSGSSSSVTTAATAASSGA 949
            ||              .:....:|.||  :|.|..:.......|.|||
Zfish   800 SP--------------CEPPTLKPMEP--SPEKCPKKVKFDGETFSTS----------------- 831

  Fly   950 GTLNHVLSSAPPTASSFALTQNNSSGGGALASGTGIGGSSSAGTAAAASLTSTALAMNSKLSANL 1014
             .||.:.....|       ::||.                   ..|.::||..|..:|.:.:...
Zfish   832 -LLNGLSPDVLP-------SENNV-------------------MVATSTLTEPANIVNRRTAVLF 869

  Fly  1015 PVKSPKRPGRYRRVPEVRHSSSMSPKKSPN---PAVT---------VSQALPMPETLPFERIPDS 1067
                             |.|.:.||:|..|   |::.         :|..:|..|||...|
Zfish   870 -----------------RKSKNTSPQKLLNTSEPSIDCPQLGTKTFLSVVIPRLETLLQHR---- 913

  Fly  1068 FRVYRANNQRDVSDSDDAPSQSSSPCSSCSDFSMSGSCSDFDSDEASEGDADGDPDRDGGRSRSE 1132
                    :|..|.|.|:|.:.........|..:|...|     |..:|.....|.....|..||
Zfish   914 --------KRTHSASGDSPDEEDECPIKRLDTGLSNGFS-----EPKKGIIVTRPSEPRRRCASE 965

  Fly  1133 ERDSTSQEGTTDAMDMQHASLNNVQGNNGNMAISSSSGGSGGSSSEDDELEERPLSARQNKPMKV 1197
            ...|:|..|             ::|.|:.:  :|.:..|.|           :...||:|
Zfish   966 SSISSSGSG-------------SIQENSSD--VSHTKSGKG-----------KLAMARRN----- 999

  Fly  1198 GTRGTPTPTTMARAVALSAGRGRGKRRSNLSESTSSTATPPPLRRAGKLRSATPNASPLVNNIKA 1262
                    ||..:           |...|.:|       |..:.:|.||.:...:     :||..
Zfish  1000 --------TTDDK-----------KELLNCTE-------PGNISKANKLAAEIDS-----SNIWM 1033

  Fly  1263 RRNTTAAGSAPLTNNNRSKHSEDSASSERHNNHSHGQKPALEPLQLVWAKCRGYPWYPALILDPK 1327
            ..|||     ||.                           ||||::||||..|||.|||||:||:
Zfish  1034 PANTT-----PLN---------------------------LEPLKVVWAKLSGYPSYPALIIDPQ 1066

  Fly  1328 TPK-GFVYNGVPLPAPPTDVL---ALRKNCLDEIVFLVLFFDVKRTWQWLPANKLDILGIDKQLD 1388
            .|: |...|...:|.||.|||   .|.:....|.:|||.|||.||.|||||.:|:...|:||.||
Zfish  1067 LPRVGCHLNEEYIPTPPRDVLRVGELMQFRSKEKLFLVRFFDSKRNWQWLPKSKMVPFGMDKTLD 1131

  Fly  1389 QQKLVESRKPAERKAVKKAYQDALHYQSQVSDL 1421
            ::|::|.|....||||:.|:..|:::.|.|.||
Zfish  1132 KRKMLEGRTSGIRKAVQSAFNRAMNHLSLVQDL 1164

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_610266.1	SFP1	<22..61	CDD:227516
		COG5141	203..>625	CDD:227470	227/442 (51%)
		Bromo_brd1_like	615..712	CDD:99944	48/96 (50%)
		MSCRAMM_ClfA	<1080..1163	CDD:468110	18/82 (22%)
		PWWP_BRPF	1303..1414	CDD:438964	57/114 (50%)
brd1b	XP_005163199.1	EPL1	45..193	CDD:463128	50/155 (32%)
		COG5141	142..>566	CDD:227470	222/429 (52%)
		Bromo_brd1_like	559..656	CDD:99944	48/96 (50%)
		PWWP	1042..1161	CDD:470613	58/118 (49%)