DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn43Ad and SERPINA6

DIOPT Version :9

Sequence 1:	NP_610261.1	Gene:	Spn43Ad / 35639	FlyBaseID:	FBgn0044011	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_001747.3	Gene:	SERPINA6 / 866	HGNCID:	1540	Length:	405	Species:	Homo sapiens

Alignment Length:	400	Identity:	94/400 - (23%)
Similarity:	167/400 - (41%)	Gaps:	47/400 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LTLPVDG--ELLARSPASVSSNR-------------FGLRLTTKLGLTQPDANVVVSPLLIQAAL 67
            |.||..|  .:.|..|.:...|.             |...|...|....|..|:.:||:.|..||
Human    10 LWLPTSGLWTVQAMDPNAAYVNMSNHHRGLASANVDFAFSLYKHLVALSPKKNIFISPVSISMAL 74

  Fly    68 SLLYAESSSEYGSQLRQAL--ELTHASHPKLAVQDFETL-----LTDLKQSAAIGCRLRLLSDLY 125
            ::|...:.....:||.|.|  .||..|..::. |.|:.|     .:|......:|..|.|...|.
Human    75 AMLSLGTCGHTRAQLLQGLGFNLTERSETEIH-QGFQHLHQLFAKSDTSLEMTMGNALFLDGSLE 138

  Fly   126 AQQRFTFNFRNEFETLAARMGVGCHRLSWESASNAAQDINYAFLSRSNFSLGELVSAPQLESLAE 190
            ..:.|:.:.::.:|:....|       :::..:.|::.||....:::...:.:|.|.  |:|.|
Human   139 LLESFSADIKHYYESEVLAM-------NFQDWATASRQINSYVKNKTQGKIVDLFSG--LDSPA- 193

  Fly   191 HNTPFLHVSGVTFRAPWAWAFDPTETQSINFFAGGNRPRLVDAMFGQHRYRYAEVPALDAQLIEV 255
               ..:.|:.:.|:..|...||...|:..||:........|..|.......|.....|..||:::
Human   194 ---ILVLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDSELPCQLVQM 255

  Fly   256 PFATADLRMLIVFPNRPDGLAQLERKLAQSDLHQLRSQLEERKVALTLPKLRVLVHSDLKHVLEE 320
            .: ..:..:..:.|:: ..:..:...|::..:::..:.|...:|.|.:||:.:....||..||||
Human   256 NY-VGNGTVFFILPDK-GKMNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEE 318

  Fly   321 LGLAKLFTSEVHLSEVFSSILSSSAPPLGAVVQSGLLELQEDGGNADDSFSFG---DLFRRALPL 382
            :|:|.|||::.:    ||.|...:......||...:|:|.|:|  .|.:.|.|   :|..:.:.|
Human   319 MGIADLFTNQAN----FSRITQDAQLKSSKVVHKAVLQLNEEG--VDTAGSTGVTLNLTSKPIIL 377

  Fly   383 VINHPFFYAI 392
            ..|.||...|
Human   378 RFNQPFIIMI 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ad	NP_610261.1	SERPIN	35..404	CDD:238101	87/380 (23%)
SERPINA6	NP_001747.3	alpha-1-antitrypsin_like	42..401	CDD:239011	86/367 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020