DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ad and SERPING1

DIOPT Version :9

Sequence 1:	NP_610261.1	Gene:	Spn43Ad / 35639	FlyBaseID:	FBgn0044011	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_000053.2	Gene:	SERPING1 / 710	HGNCID:	1228	Length:	500	Species:	Homo sapiens

Alignment Length:	384	Identity:	85/384 - (22%)
Similarity:	157/384 - (40%)	Gaps:	51/384 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 FGLRLTTKL-GLTQPDANVVVSPLLIQAALSLLYAESSSEYGSQLRQALELTHASHPKLAVQDFE 102
            |.|:|.... .:.:.:.|:..||..|.:.|:.:...:.....:.|...|     |:||    ||.
Human   149 FSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLGAGENTKTNLESIL-----SYPK----DFT 204

  Fly   103 TLLTDLKQSAAIGCRLRLLSDLYAQQRFTF--NFRNEFETL---AARMGVGCHRLSWESASNAAQ 162
            .:...||.....|  :..:|.::.......  .|.|...||   :.|:      ||..|.:| .:
Human   205 CVHQALKGFTTKG--VTSVSQIFHSPDLAIRDTFVNASRTLYSSSPRV------LSNNSDAN-LE 260

  Fly   163 DINYAFLSRSNFSLGELVSAPQLESLAEHNTPFLHVSGVTFRAPWAWAFDPTETQSINFFAGGNR 227
            .||......:|..:..|     |:||.. :|..:.::.:...|.|...|||.:|:...|....:.
Human   261 LINTWVAKNTNNKISRL-----LDSLPS-DTRLVLLNAIYLSAKWKTTFDPKKTRMEPFHFKNSV 319

  Fly   228 PRLVDAMFGQHRYRYAEV--PALDAQLIEVPFATADLRMLIVFP-NRPDGLAQLERKLAQSDLHQ 289
            .::  .|....:|..|..  ..|.|::.::.. :.:|.::|:.| |....|..:|:.|:.|....
Human   320 IKV--PMMNSKKYPVAHFIDQTLKAKVGQLQL-SHNLSLVILVPQNLKHRLEDMEQALSPSVFKA 381

  Fly   290 LRSQLEERK---VALTLPKLRVLVHSDLKHVLEELGLAKLFTSEVHLSEVFSSILSSSAPPL--G 349
            :..:||..|   ..||||:::|....|:..::|:|.... |:.:::|..:      :..|.|  .
Human   382 IMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFFD-FSYDLNLCGL------TEDPDLQVS 439

  Fly   350 AVVQSGLLELQEDGGNADDSFSFGDLFRRALPLVINHPFFYAIGN--GKTLLLSGHIVD 406
            |:....:|||.|.|..|..:.:. .:.|..|...:..||.:.:.:  .|..:..|.:.|
Human   440 AMQHQTVLELTETGVEAAAASAI-SVARTLLVFEVQQPFLFVLWDQQHKFPVFMGRVYD 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ad	NP_610261.1	SERPIN	35..404	CDD:238101	84/380 (22%)
SERPING1	NP_000053.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..43
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..118
		7 X 4 AA tandem repeats of [QE]-P-T-[TQ]	85..119
		C1_inh	145..495	CDD:239005	84/380 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010