DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ad and Serpinb2

DIOPT Version :9

Sequence 1:	NP_610261.1	Gene:	Spn43Ad / 35639	FlyBaseID:	FBgn0044011	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_067728.1	Gene:	Serpinb2 / 60325	RGDID:	621823	Length:	416	Species:	Rattus norvegicus

Alignment Length:	452	Identity:	84/452 - (18%)
Similarity:	168/452 - (37%)	Gaps:	127/452 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SVSSNRFGLRLTTKLGLTQPDANVVVSPLLIQAALSLLYAESSSEYGSQLRQAL--------ELT 89
            |:::..|.|.|..::..:....|:.:||..|.:.|::::..:.:....|:.:.|        :||
  Rat     5 SMANTMFALNLLKQIEQSNSTQNIFISPWSISSTLAIVFLGAQANTEEQMAKVLNFDKIGSYDLT 69

  Fly    90 HASHPKLAVQDFETLLTDLKQSAAIGCRLRLLSDLYAQQRFTFNFRNEFETLAARMG---VGCHR 151
            ..:.......||...:.......||         |.||.|  ....:.|.:|::.:.   :|.:.
  Rat    70 PGNPENFHGCDFAQHIQRDNYPVAI---------LQAQAR--DKIHSAFSSLSSTINTPRLGDYL 123

  Fly   152 LS----------------------------------WESASNAAQDINYAFLSRSNFSLGELVSA 182
            |.                                  .|.|:.|.:.||....:::.   ||:
  Rat   124 LESANKLFGEKSARFKEEYIQRCKKYYSTEPEAVDFLECANEARKKINSWVKTQTK---GEI--- 182

  Fly   183 PQL--ESLAEHNTPFLHVSGVTFRAPWAWAFDPTETQSINFFAGGNRPRLVDAMFGQHRYRYAEV 245
            |.|  |...:.:|..:.|:.:.|:..|...|.........|....|..:.|..|:.:.:.....:
  Rat   183 PNLLPEGSVDEDTKMVLVNTIYFKGRWKTPFQKRLNGLYPFRVNLNESKPVQMMYLREKLNIGYI 247

  Fly   246 PALDAQLIEVPFATADLRMLIVFPNRPD----GLAQLERKLAQSDLHQLRSQ--LEERKVALTLP 304
            ..|..|::|:|: ..::.|.::.|:..:    ||..|||::...:.::..|:  |:|..|.:.:|
  Rat   248 KDLKTQILELPY-IGNISMFLLLPDEIEDSSTGLEMLEREINFDNFNKWISKETLDEDDVLVYIP 311

  Fly   305 KLRVLVHSDLKHVLEELGLAKLF------------TSEVHLSEVFSSILSSSAPPLGAVVQSGLL 357
            |.::..:.:||.:|:.:|:...|            ::::.|||||               ....:
  Rat   312 KFKLAQNYELKPILQRMGMEDAFNKGKADFSGMSESNDLFLSEVF---------------HQATV 361

  Fly   358 ELQEDG---------------GNADDSFSFGDLFRRALPLVINHPFFYAIGNG--KTLLLSG 402
            ::.|:|               |:....|            |.:|||.:.|.|.  :|:|..|
  Rat   362 DVNEEGTVAAGGTGAVMTGRTGHGGPQF------------VADHPFLFFIMNNITRTILFVG 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ad	NP_610261.1	SERPIN	35..404	CDD:238101	83/450 (18%)
Serpinb2	NP_067728.1	serpinB2_PAI-2	2..416	CDD:381029	84/452 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920