DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ad and SERPINB10

DIOPT Version :9

Sequence 1:	NP_610261.1	Gene:	Spn43Ad / 35639	FlyBaseID:	FBgn0044011	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_005015.1	Gene:	SERPINB10 / 5273	HGNCID:	8942	Length:	397	Species:	Homo sapiens

Alignment Length:	401	Identity:	90/401 - (22%)
Similarity:	170/401 - (42%)	Gaps:	40/401 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SVSSNRFGLRLTTKLGLTQPDANVVVSPLLIQAALSLLYAESSSEYGSQLRQALELT-------- 89
            :.|.|:|.|.|:.||..:....|:..|...|..:|:::|..:.....:|:.|.|:..
Human     5 ATSINQFALELSKKLAESAQGKNIFFSSWSISTSLTIVYLGAKGTTAAQMAQVLQFNRDQGVKCD 69

  Fly    90 -----------HASHPKLAVQDFETLLTD-LKQSAAIGCRLRLLSDLYAQQRFTFNFRNEF-ETL 141
                       :.|:.:....||:||::: ||.:.  ...|:..:.:|.::  |:.|.|:: |.:
Human    70 PESEKKRKMEFNLSNSEEIHSDFQTLISEILKPND--DYLLKTANAIYGEK--TYAFHNKYLEDM 130

  Fly   142 AARMGVGCHRLSW-ESASNAAQDINYAFLSRSNFSLGELVSAPQLESLAEHNTPFLHVSGVTFRA 205
            ....|.....::: |::....:|||.....::...:..|:....::|    .|..:.|:.:.|:.
Human   131 KTYFGAEPQPVNFVEASDQIRKDINSWVERQTEGKIQNLLPDDSVDS----TTRMILVNALYFKG 191

  Fly   206 PWAWAFDPTETQSINFFAGGNRPRLVDAMFGQHRYRYAEVPALDAQLIEVPFATADLRMLIVFPN 270
            .|...|....|....|.......:.|..||.:.:.....:....|..:::.:.:.||.:||:.|.
Human   192 IWEHQFLVQNTTEKPFRINETTSKPVQMMFMKKKLHIFHIEKPKAVGLQLYYKSRDLSLLILLPE 256

  Fly   271 RPDGLAQLERKLAQSDLHQLRS--QLEERKVALTLPKLRVLVHSDLKHVLEELGLAKLFTSEVHL 333
            ..:||.|||:.:....|::..|  .:|..:|.|.|||.::....|||..|..:|::..|:..
Human   257 DINGLEQLEKAITYEKLNEWTSADMMELYEVQLHLPKFKLEDSYDLKSTLSSMGMSDAFSQS--- 318

  Fly   334 SEVFSSILSSSAPPLGAVVQSGLLELQEDGGNADDSFSFGDLFRRALPLV---INHPFFYAIGNG 395
            ...||.:.|:....|..|.....:|:.|.|..|..........|..:|.:   .||||.:.|.:.
Human   319 KADFSGMSSARNLFLSNVFHKAFVEINEQGTEAAAGSGSEIDIRIRVPSIEFNANHPFLFFIRHN 383

  Fly   396 K--TLLLSGHI 404
            |  |:|..|.:
Human   384 KTNTILFYGRL 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ad	NP_610261.1	SERPIN	35..404	CDD:238101	90/397 (23%)
SERPINB10	NP_005015.1	PAI-2	4..397	CDD:239013	90/401 (22%)
SERPINB10	NP_005015.1	Nuclear localization signal	74..77		0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920