Protein Alignment Spn43Ad and SERPINB10

DIOPT Version :10

• Sequence 1: NP_610261.1
• Gene: Spn43Ad / 35639
• FlyBaseID: FBgn0044011
• Length: 407
• Species: Drosophila melanogaster
• Sequence 2: NP_005015.1
• Gene: SERPINB10 / 5273
• HGNCID: 8942
• Length: 397
• Species: Homo sapiens
• Alignment Length: 401
• Identity: 90/401 - (22%)
• Similarity: 170/401 - (42%)
• Gaps: 40/401 - (9%)

  Fly    33 SVSSNRFGLRLTTKLGLTQPDANVVVSPLLIQAALSLLYAESSSEYGSQLRQALELT-------- 89
            :.|.|:|.|.|:.||..:....|:..|...|..:|:::|..:.....:|:.|.|:..
Human     5 ATSINQFALELSKKLAESAQGKNIFFSSWSISTSLTIVYLGAKGTTAAQMAQVLQFNRDQGVKCD 69

  Fly    90 -----------HASHPKLAVQDFETLLTD-LKQSAAIGCRLRLLSDLYAQQRFTFNFRNEF-ETL 141
                       :.|:.:....||:||::: ||.:.  ...|:..:.:|.::  |:.|.|:: |.:
Human    70 PESEKKRKMEFNLSNSEEIHSDFQTLISEILKPND--DYLLKTANAIYGEK--TYAFHNKYLEDM 130

  Fly   142 AARMGVGCHRLSW-ESASNAAQDINYAFLSRSNFSLGELVSAPQLESLAEHNTPFLHVSGVTFRA 205
            ....|.....::: |::....:|||.....::...:..|:....::|    .|..:.|:.:.|:.
Human   131 KTYFGAEPQPVNFVEASDQIRKDINSWVERQTEGKIQNLLPDDSVDS----TTRMILVNALYFKG 191

  Fly   206 PWAWAFDPTETQSINFFAGGNRPRLVDAMFGQHRYRYAEVPALDAQLIEVPFATADLRMLIVFPN 270
            .|...|....|....|.......:.|..||.:.:.....:....|..:::.:.:.||.:||:.|.
Human   192 IWEHQFLVQNTTEKPFRINETTSKPVQMMFMKKKLHIFHIEKPKAVGLQLYYKSRDLSLLILLPE 256

  Fly   271 RPDGLAQLERKLAQSDLHQLRS--QLEERKVALTLPKLRVLVHSDLKHVLEELGLAKLFTSEVHL 333
            ..:||.|||:.:....|::..|  .:|..:|.|.|||.::....|||..|..:|::..|:..
Human   257 DINGLEQLEKAITYEKLNEWTSADMMELYEVQLHLPKFKLEDSYDLKSTLSSMGMSDAFSQS--- 318

  Fly   334 SEVFSSILSSSAPPLGAVVQSGLLELQEDGGNADDSFSFGDLFRRALPLV---INHPFFYAIGNG 395
            ...||.:.|:....|..|.....:|:.|.|..|..........|..:|.:   .||||.:.|.:.
Human   319 KADFSGMSSARNLFLSNVFHKAFVEINEQGTEAAAGSGSEIDIRIRVPSIEFNANHPFLFFIRHN 383

  Fly   396 K--TLLLSGHI 404
            |  |:|..|.:
Human   384 KTNTILFYGRL 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ad	NP_610261.1	serpin42Dd-like_insects	34..407	CDD:381070	90/400 (23%)
SERPINB10	NP_005015.1	serpinB10_bomapin	1..397	CDD:381035	90/401 (22%)
		Nuclear localization signal	74..77		0/2 (0%)