DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ad and SERPINE2

DIOPT Version :9

Sequence 1:	NP_610261.1	Gene:	Spn43Ad / 35639	FlyBaseID:	FBgn0044011	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	XP_005246698.1	Gene:	SERPINE2 / 5270	HGNCID:	8951	Length:	410	Species:	Homo sapiens

Alignment Length:	417	Identity:	88/417 - (21%)
Similarity:	169/417 - (40%)	Gaps:	36/417 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 IHWRLLSALLVGLAIALTLP-VDGELLARSPASVSSNRFGLRLTTKLGLTQPDANVVVSPLLIQA 65
            ::|.|...||.    ::||| :.......|...:.||. |:::..::..::|..|:|:||..|.:
Human    13 MNWHLPLFLLA----SVTLPSICSHFNPLSLEELGSNT-GIQVFNQIVKSRPHDNIVISPHGIAS 72

  Fly    66 ALSLLYAESSSEYGSQLRQALELTHASHPKLAVQDFETLLTDLKQSAAIGCRLRLLSDLYAQQRF 130
            .|.:|...:......||...:........|: ::.....:...|....:.....:.....::...
Human    73 VLGMLQLGADGRTKKQLAMVMRYGVNGVGKI-LKKINKAIVSKKNKDIVTVANAVFVKNASEIEV 136

  Fly   131 TFNFRNE--FETLAARMGVGC--HRLSWESASNAAQDINYAFLSRSNFSLGELVSAPQLESLAEH 191
            .|..||:  |:         |  ..:::|..::|...||....:.:...:..|:|...::.:.
Human   137 PFVTRNKDVFQ---------CEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVL-- 190

  Fly   192 NTPFLHVSGVTFRAPWAWAFDPTETQSINFFAGGNRPRLVDAMFGQHRYRYAEVPA---LDAQLI 253
             |..:.|:.|.|:..|...|.|..|:...|.|...:...|..:.....:|.....|   |....|
Human   191 -TRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFI 254

  Fly   254 EVPFATADLRMLIVFPNRPD-GLAQLERKLAQSDLHQLRSQLEERKVALTLPKLRVLVHSDLKHV 317
            |:|:....:.|||..|.... .|:.:...::...:....|.:..::|.:.|||...:..:|||..
Human   255 ELPYHGESISMLIALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEP 319

  Fly   318 LEELGLAKLFTSEVHLSEVFSSILSSSAP-PLGAVVQSGLLELQEDGGNADDSFSFGDLFRRALP 381
            |:.||:..:|.|.   ...|:.|.:.|.. .:..::|...:|:.|||..| .:.:...|..|:.|
Human   320 LKVLGITDMFDSS---KANFAKITTGSENLHVSHILQKAKIEVSEDGTKA-SAATTAILIARSSP 380

  Fly   382 --LVINHPFFYAIGNGKT--LLLSGHI 404
              .:::.||.:.|.:..|  :|..|.|
Human   381 PWFIVDRPFLFFIRHNPTGAVLFMGQI 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ad	NP_610261.1	SERPIN	35..404	CDD:238101	79/381 (21%)
SERPINE2	XP_005246698.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020