DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ad and SERPINA4

DIOPT Version :9

Sequence 1:	NP_610261.1	Gene:	Spn43Ad / 35639	FlyBaseID:	FBgn0044011	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_001275961.1	Gene:	SERPINA4 / 5267	HGNCID:	8948	Length:	464	Species:	Homo sapiens

Alignment Length:	444	Identity:	108/444 - (24%)
Similarity:	169/444 - (38%)	Gaps:	61/444 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIHWRLLSALLVGLAIALT-----LPVDGELLARS------------------PASVSSNRFGLR 42
            :|.:.||  ||||| :||:     :..|||..:.|                  ||:..   |..|
Human    40 LIDYLLL--LLVGL-LALSHGQLHVEHDGESCSNSSHQQILETGEGSPSLKIAPANAD---FAFR 98

  Fly    43 LTTKLGLTQPDANVVVSPLLIQAALSLLYAESSSEYGSQLRQAL--ELTHASHPKLAVQDFETLL 105
            ....:....|..|:..|||.|.||.::|...:.|...||:.:.|  .||..|...:. :.|:.||
Human    99 FYYLIASETPGKNIFFSPLSISAAYAMLSLGACSHSRSQILEGLGFNLTELSESDVH-RGFQHLL 162

  Fly   106 TDLKQSAAIGCRLRLLSDLYAQQ--RFTFNFRNEFETLAARMGVGCHRLSWESASNAAQDINYAF 168
            ..|..... |...|:.|.|:...  :|...|.|  :|:|.......|...:::. ...|.||...
Human   163 HTLNLPGH-GLETRVGSALFLSHNLKFLAKFLN--DTMAVYEAKLFHTNFYDTV-GTIQLINDHV 223

  Fly   169 LSRSNFSLGELVSAPQLESLAEHNTPFLHVSGVTFRAPWAWAFDPTETQSINFFAGGNRPRLVDA 233
            ...:...:.:|||..:.:.|      .:.|:.:.|:|.|...|..:.|...:|:...|....|..
Human   224 KKETRGKIVDLVSELKKDVL------MVLVNYIYFKALWEKPFISSRTTPKDFYVDENTTVRVPM 282

  Fly   234 MF-GQHRYRYAEVPALDAQLIEVPFATADLRMLIVFPNRPDGLAQLERKLAQSDLHQLRSQLEER 297
            |. .|..:.|.....|...::.:.: ..|..:..:.||: ..:.::|..|....|.:..:.|.:|
Human   283 MLQDQEHHWYLHDRYLPCSVLRMDY-KGDATVFFILPNQ-GKMREIEEVLTPEMLMRWNNLLRKR 345

  Fly   298 ----KVALTLPKLRVLVHSDLKHVLEELGLAKLFTSEVHLSEVFSSILSSSAPPLGAVVQSGLLE 358
                |:.|.|||..:.....|..:|..||...||:....|    |.|................|:
Human   346 NFYKKLELHLPKFSISGSYVLDQILPRLGFTDLFSKWADL----SGITKQQKLEASKSFHKATLD 406

  Fly   359 LQEDGGNADDSFSFGDLFRRALP----LVINHPFFYAIGNGKT--LLLSGHIVD 406
            :.|.|..|..:.||...|..|..    |..|.||...|.:..|  :|..|.:||
Human   407 VDEAGTEAAAATSFAIKFFSAQTNRHILRFNRPFLVVIFSTSTQSVLFLGKVVD 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ad	NP_610261.1	SERPIN	35..404	CDD:238101	90/383 (23%)
SERPINA4	NP_001275961.1	alpha-1-antitrypsin_like	91..458	CDD:239011	91/386 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020