DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ad and SERPINA1

DIOPT Version :9

Sequence 1:	NP_610261.1	Gene:	Spn43Ad / 35639	FlyBaseID:	FBgn0044011	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_000286.3	Gene:	SERPINA1 / 5265	HGNCID:	8941	Length:	418	Species:	Homo sapiens

Alignment Length:	453	Identity:	102/453 - (22%)
Similarity:	175/453 - (38%)	Gaps:	91/453 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 IHWRLLSALLVGLA----IALTLPVDGELLARSPAS-----------VSSN--RFGLRLTTKLGL 49
            :.|.:|  ||.||.    ::|.....|:...::..|           ::.|  .|...|..:|..
Human     5 VSWGIL--LLAGLCCLVPVSLAEDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFSLYRQLAH 67

  Fly    50 TQPDANVVVSPLLIQAALSLLYAESSSEYGSQLRQALELTHASHPKLAVQD-FETLLTDLKQS-- 111
            .....|:..||:.|..|.::|...:.::...::.:.|.......|:..:.: |:.||..|.|.
Human    68 QSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDS 132

  Fly   112 -----------AAIGCRL--RLLSD---LYAQQRFTFNFRNEFETLAARMGVGCHRLSWESASNA 160
                       .:.|.:|  :.|.|   ||..:.||.||.:..|                    |
Human   133 QLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEE--------------------A 177

  Fly   161 AQDINYAFLSRSNFSLGELVSAPQLESLAEHNTPFLHVSGVTFRAPWAWAFDPTETQSINFFAGG 225
            .:.|| .::.:.  :.|::|   .|....:.:|.|..|:.:.|:..|...|:..:|:..:|....
Human   178 KKQIN-DYVEKG--TQGKIV---DLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQ 236

  Fly   226 NRPRLVDAMFGQHRYRYAEVPALDAQLIEVPF---ATADLRMLIVFPNRPDGLAQLERKLAQSDL 287
            .....|..|.....:.......|.:.::.:.:   |||     |.|......|..||.:|....:
Human   237 VTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATA-----IFFLPDEGKLQHLENELTHDII 296

  Fly   288 HQLRSQLEERKVALTLPKLRVLVHSDLKHVLEELGLAKLFTSEVHLSEVFSSILSSSAP-PLGAV 351
            .:.....:.|..:|.||||.:....|||.||.:||:.|:|::...||.|     :..|| .|...
Human   297 TKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGV-----TEEAPLKLSKA 356

  Fly   352 VQSGLLELQEDGGNADDSFSFGDLFRRALPLVI------NHPFFYAI--GNGKTLLLSGHIVD 406
            |...:|.:.|.|..|     .|.:|..|:|:.|      |.||.:.:  .|.|:.|..|.:|:
Human   357 VHKAVLTIDEKGTEA-----AGAMFLEAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVN 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ad	NP_610261.1	SERPIN	35..404	CDD:238101	92/401 (23%)
SERPINA1	NP_000286.3	alpha-1-antitrypsin_like	55..412	CDD:239011	91/397 (23%)
SERPINA1	NP_000286.3	RCL	368..392		7/28 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010