DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn43Ad and SERPINF1

DIOPT Version :9

Sequence 1:	NP_610261.1	Gene:	Spn43Ad / 35639	FlyBaseID:	FBgn0044011	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_001316832.1	Gene:	SERPINF1 / 5176	HGNCID:	8824	Length:	418	Species:	Homo sapiens

Alignment Length:	395	Identity:	97/395 - (24%)
Similarity:	154/395 - (38%)	Gaps:	56/395 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ASVSSNRFGLRLTTKLGLTQPDANVVVSPLLIQAALSLLYAESSSEYGSQLRQALELTHASHPKL 96
            |:||:  ||..|......|.|..||::|||.:..|||.|...:.....|.:.:||.....|.|.:
Human    56 AAVSN--FGYDLYRVRSSTSPTTNVLLSPLSVATALSALSLGAEQRTESIIHRALYYDLISSPDI 118

  Fly    97 AVQDFETLLT------DLKQSAAI--GCRLRLLSDLYAQQRFTFNFRNEFETLAARMGVGCHRLS 153
            .....|.|.|      :||.::.|  ..:||:.|...|....::..|       .|:..|..||.
Human   119 HGTYKELLDTVTAPQKNLKSASRIVFEKKLRIKSSFVAPLEKSYGTR-------PRVLTGNPRLD 176

  Fly   154 WESASNAAQDINYAFLSRSNFSLGELVSAPQLESLAEHNTPFLHVSGVT-FRAPWAWAFDPTETQ 217
            .:..:|..|......|:||...:.:.:|              :.:.||. |:..|...||..:|.
Human   177 LQEINNWVQAQMKGKLARSTKEIPDEIS--------------ILLLGVAHFKGQWVTKFDSRKTS 227

  Fly   218 SINFFAGGNRPRLVDAMFGQHR-YRYAEVPALDAQLIEVPFATADLRMLIVFPNR-PDGLAQLER 280
            ..:|:....|...|..|..... .||.....|..::.::|. |..:.::...|.: ...|..:|.
Human   228 LEDFYLDEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPL-TGSMSIIFFLPLKVTQNLTLIEE 291

  Fly   281 KLAQSDLHQLRSQLEERKVALTLPKLRVLVHSDLKHVLEELGLAKLFTSEVHLSEVFSSILSSSA 345
            .|....:|.:..:|:..:..||:|||::....::...|:|:.|..||.     |..||.| :...
Human   292 SLTSEFIHDIDRELKTVQAVLTVPKLKLSYEGEVTKSLQEMKLQSLFD-----SPDFSKI-TGKP 350

  Fly   346 PPLGAVVQSGLLELQEDGGNADDS-------FSFGDLFRRALPLVINHPFFYAIGNGKT--LLLS 401
            ..|..|......|..|||.....|       .:|      .|...:|.||.:.:.:..|  ||..
Human   351 IKLTQVEHRAGFEWNEDGAGTTPSPGLQPAHLTF------PLDYHLNQPFIFVLRDTDTGALLFI 409

  Fly   402 GHIVD 406
            |.|:|
Human   410 GKILD 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ad	NP_610261.1	SERPIN	35..404	CDD:238101	93/388 (24%)
SERPINF1	NP_001316832.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..39
		PEDF	40..415	CDD:239007	97/395 (25%)
		O-glycosylated at one site	371..383		1/11 (9%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010