DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ad and SERPINE1

DIOPT Version :9

Sequence 1:	NP_610261.1	Gene:	Spn43Ad / 35639	FlyBaseID:	FBgn0044011	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_001373389.1	Gene:	SERPINE1 / 5054	HGNCID:	8583	Length:	492	Species:	Homo sapiens

Alignment Length:	414	Identity:	80/414 - (19%)
Similarity:	161/414 - (38%)	Gaps:	53/414 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LSALLVGLAIALTLPVDGELLARSPASVS--SNRFGLRLTTKLGLTQPDANVVVSPLLIQAALSL 69
            |:.|::|||:...   :|..:...|:.|:  ::.||:|:..::.....|.|||.||..:.:.|::
Human     7 LTCLVLGLALVFG---EGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAM 68

  Fly    70 LYAESSSEYGSQLRQALELTHASHPKLAVQDFETLLTDLKQSAAIGCRLRLLSDLYAQQRFTFNF 134
            |...:..|...|::.|:...               :.|...:.|       |..||.:....:|
Human    69 LQLTTGGETQQQIQAAMGFK---------------IDDKGMAPA-------LRHLYKELMGPWN- 110

  Fly   135 RNEFETLAA-------RMGVGCHRLSWESASNAAQDINYAFLSRSNFSLGE--------LVSAPQ 184
            ::|..|..|       ::..|.....:....:..:.::::.:.|:.|.:.:        ::|...
Human   111 KDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLL 175

  Fly   185 LESLAEHNTPFLHVSGVTFRAPWAWAFDPTETQSINFFAGGNRPRLVDAMFGQHRYRYAEVPALD 249
            .:...:..|..:.|:.:.|...|...|..:.|....|.........|..|...:::.|.|....|
Human   176 GKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD 240

  Fly   250 A---QLIEVPFATADLRMLIVFPNRPD-GLAQLERKLAQSDLHQLRSQLEERKVALTLPKLRVLV 310
            .   .::|:|:....|.|.|..|...: .|:.|...|:...:...:..:......|.|||..:..
Human   241 GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLET 305

  Fly   311 HSDLKHVLEELGLAKLFTSEVHLSEVFSSILSSSAPPLGAVVQSGLLELQEDGGNADDSFSFGDL 375
            ..||:..||.||:..:|.   .....|:|:.......:...:|...:|:.|.|..|..|.:. .:
Human   306 EVDLRKPLENLGMTDMFR---QFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAV-IV 366

  Fly   376 FRRALP--LVINHPFFYAIGNGKT 397
            ..|..|  ::::.||.:.:.:..|
Human   367 SARMAPEEIIMDRPFLFVVRHNPT 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ad	NP_610261.1	SERPIN	35..404	CDD:238101	72/386 (19%)
SERPINE1	NP_001373389.1	serpinE1_PAI-1	29..393	CDD:381007	73/389 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020