Protein Alignment Spn43Ad and SERPINC1

DIOPT Version :10

• Sequence 1: NP_610261.1
• Gene: Spn43Ad / 35639
• FlyBaseID: FBgn0044011
• Length: 407
• Species: Drosophila melanogaster
• Sequence 2: NP_001373231.1
• Gene: SERPINC1 / 462
• HGNCID: 775
• Length: 505
• Species: Homo sapiens
• Alignment Length: 519
• Identity: 106/519 - (20%)
• Similarity: 182/519 - (35%)
• Gaps: 153/519 - (29%)

  Fly     6 LLSALLVGLAIALT---------------LPVDGELLARSP------------------------ 31
            |||.||:|....:|               :|::...:.|||
Human    18 LLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMNPMCIYRSPEKKATEDEGSEQKIPEATNRRVWE 82

  Fly    32 ASVSSNRFGLRLTTKLGLTQPD-ANVVVSPLLIQAALSLLYAESSSEYGSQLRQALELTHASHPK 95
            .|.:::||.......|..::.| .|:.:|||.|..|.::....:.::   .|:|.:|
Human    83 LSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACND---TLQQLME-------- 136

  Fly    96 LAVQDFETLLTDLKQS-----AAIGCRL--------RLLS--DLYAQQRFTFN------------ 133
              |..|:|:.......     |.:.|||        :|:|  .|:..:..|||
Human   137 --VFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYG 199

  Fly   134 -------FRNEFETLAARMGVGCHRLSWES-----------ASNAAQDINYAFLSRSNF--SLGE 178
                   |:...|...|.:.      .|.|           .|.|..::....|..:.:  .|..
Human   200 AKLQPLDFKENAEQSRAAIN------KWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKVLRM 258

  Fly   179 LVSAPQLESLAEHNTPFL---------HVSGV--TFRAPWAWAFDPTETQSINFFAGGNRPRLVD 232
            .:..||...||...|||.         ..:|:  ..:..|...|.|..|:...|:..........
Human   259 ALERPQGLPLALQLTPFFFKWRDRSPERANGLPKATQGLWKSKFSPENTRKELFYKADGESCSAS 323

  Fly   233 AMFGQHRYRYAEVPALDAQLIEVPFATADLRMLIVFPNRPDGLAQLERKLAQSDLHQLRSQLEER 297
            .|:.:.::||..| |...|::|:||...|:.|:::.|.....||::|::|....|.:...:|||.
Human   324 MMYQEGKFRYRRV-AEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEM 387

  Fly   298 KVALTLPKLRVLVHSDLKHVLEELGLAKLFTSE--------------VHLSEVFSSILSSSAPPL 348
            .:.:.:|:.|:.....||..|:::||..||:.|              :::|:.|
Human   388 MLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAF----------- 441

  Fly   349 GAVVQSGLLELQEDGGNADDSFSFGDLFRRALP----LVINHPFFYAIGNG--KTLLLSGHIVD 406
                ....||:.|:|..|..|.:.....|...|    ...|.||...|...  .|::..|.:.:
Human   442 ----HKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVAN 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ad	NP_610261.1	serpin42Dd-like_insects	34..407	CDD:381070	94/452 (21%)
SERPINC1	NP_001373231.1	serpinC1_AT3	70..504	CDD:381002	95/467 (20%)