DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ad and serpine2

DIOPT Version :9

Sequence 1:	NP_610261.1	Gene:	Spn43Ad / 35639	FlyBaseID:	FBgn0044011	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_956478.1	Gene:	serpine2 / 393153	ZFINID:	ZDB-GENE-040426-848	Length:	395	Species:	Danio rerio

Alignment Length:	406	Identity:	96/406 - (23%)
Similarity:	169/406 - (41%)	Gaps:	46/406 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GELLARSPASVS---SNRFGLRLTTKLGL--------TQPDANVVVSPLLIQAALSLLYAESSSE 77
            |.|......|||   |:.:|.| .:.|||        .:...||::||..:.:.|.:|...:..:
Zfish     8 GVLFLLCSVSVSQSQSSSYGAR-GSDLGLQVFMQVLQDRAQENVLLSPHGVASVLGMLLPGAHGD 71

  Fly    78 YGSQLRQALELTHASHPKLAVQDFETLLTDLKQSAAIGCRLRLLSDLYAQQRFTFNFRNEFETLA 142
            ...||...|:.......|:..:..::|.|  |.:|.|   :.:.:.|:..:  .|:.:.:|.: |
Zfish    72 TRRQLLNGLKYKKNGPYKMLRKLHKSLTT--KSNADI---VTIANALFPNE--GFSMKEDFLS-A 128

  Fly   143 ARMGVGC--HRLSWESASNAAQDINYAFLSRSNFSLGELVSAPQLESLAEHNTPFLHVSGVTFRA 205
            .|....|  |.:.:.....|||.||....:.:...:..:|:|...::..   |..:.|:.:.|:.
Zfish   129 NRENFLCESHSVDYSDPEAAAQSINDWVKNSTKGQIPSVVTADMFDTAL---TRLVAVNSIFFKG 190

  Fly   206 PWAWAFDPTETQSINFFAGGNRPRLVDAMFGQHRYRYAEVPALDAQ---LIEVPFATADLRMLIV 267
            .|...|.|..|:..:|.||......|..|.....:...:....|.|   :||:|:....:.|.|.
Zfish   191 LWKSRFQPQSTKPRSFTAGDGNTYKVPMMSQLSVFNMGQASTPDGQKYIVIELPYHGNSMSMFIA 255

  Fly   268 FPNRPD-GLAQLERKLAQSDLHQLRSQLEERKVALTLPKLRVLVHSDLKHVLEELGLAKLFTSEV 331
            .|.... .|:.:...::.:.:......:..|::.|.:||..|....||:..|:.||:..:|....
Zfish   256 LPTEDSTPLSSILPHISTNTIQSWTKLMNPRRMRLLMPKFTVEQELDLETPLKALGIKDIFDQNK 320

  Fly   332 ----HLSEVFSSILSSSAPPLGAVVQSGLLELQEDGGNADDSFSFGDLFRRALP--LVINHPFFY 390
                |||.  .||..|.|      :|...:|:.|||..|..:.|. .|..|:.|  :.::.||.:
Zfish   321 ADFRHLSS--ESIYVSKA------LQKAKIEVNEDGTKASATTSV-ILHARSSPPWVTVDRPFLF 376

  Fly   391 AI--GNGKTLLLSGHI 404
            .|  .:..|:|.:|.|
Zfish   377 LIRHNSSGTILFAGQI 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ad	NP_610261.1	SERPIN	35..404	CDD:238101	91/393 (23%)
serpine2	NP_956478.1	PAI-1_nexin-1	26..395	CDD:239006	90/388 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020