DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ad and SERPINA9

DIOPT Version :9

Sequence 1:	NP_610261.1	Gene:	Spn43Ad / 35639	FlyBaseID:	FBgn0044011	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_783866.3	Gene:	SERPINA9 / 327657	HGNCID:	15995	Length:	417	Species:	Homo sapiens

Alignment Length:	422	Identity:	88/422 - (20%)
Similarity:	176/422 - (41%)	Gaps:	55/422 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LSALLVGL--AIALTLPVDGELLARSPASV---SSNR-------------FGLRLTTKLGLTQPD 53
            :::.|.|:  |:.|..|:.....|.:|::.   ||.:             |..||..:|.|..|.
Human     1 MASYLYGVLFAVGLCAPIYCVSPANAPSAYPRPSSTKSTPASQVYSLNTDFAFRLYRRLVLETPS 65

  Fly    54 ANVVVSPLLIQAALSLLYAESSSEYGSQLRQAL--ELTHASHPKLAV-QDFETLLTDL-----KQ 110
            .|:..||:.:..:|::|...:.|...:|:.|.|  .|||.  |:.|: |.|:.|:..|     ..
Human    66 QNIFFSPVSVSTSLAMLSLGAHSVTKTQILQGLGFNLTHT--PESAIHQGFQHLVHSLTVPSKDL 128

  Fly   111 SAAIGCRLRLLSDLYAQQRFTFNFRNEFETLAARMGVGCHRLSWESASNAAQDINYAFLSRSNFS 175
            :..:|..|.:..:|..|..|..|.:..:|       .......:.:.|.|...||.....::.
Human   129 TLKMGSALFVKKELQLQANFLGNVKRLYE-------AEVFSTDFSNPSIAQARINSHVKKKTQ-- 184

  Fly   176 LGELVSAPQ-LESLAEHNTPFLHVSGVTFRAPWAWAFDPTET-QSINFFAGGNRPRLVDAMFGQH 238
             |::|...| |:.|    |..:.|:.:.|:|.|...|.|..| ::..|..|......|..|..:.
Human   185 -GKVVDIIQGLDLL----TAMVLVNHIFFKAKWEKPFHPEYTRKNFPFLVGEQVTVHVPMMHQKE 244

  Fly   239 RYRYAEVPALDAQLIEVPFATADLRMLIVFPNRPDGLAQLERKLAQSDLHQLRSQLEERKVALTL 303
            ::.:.....|:..::::.: ..|.....|.|:: ..:.|||:.|:...|.:....|::|.:.:.:
Human   245 QFAFGVDTELNCFVLQMDY-KGDAVAFFVLPSK-GKMRQLEQALSARTLRKWSHSLQKRWIEVFI 307

  Fly   304 PKLRVLVHSDLKHVLEELGLAKLFTSEVHLSEVFSSILSSSAPPLGAVVQSGLLELQEDGGNADD 368
            |:..:....:|:.:|.::|:..:|.....    ||.|....:..:.......:|::.|:|..|..
Human   308 PRFSISASYNLETILPKMGIQNVFDKNAD----FSGIAKRDSLQVSKATHKAVLDVSEEGTEATA 368

  Fly   369 SFSFGDLFRRALPLVINHPFFYAIGNGKTLLL 400
            :.:...:.|..     :.|.::.:...:|.|:
Human   369 ATTTKFIVRSK-----DGPSYFTVSFNRTFLM 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ad	NP_610261.1	SERPIN	35..404	CDD:238101	81/389 (21%)
SERPINA9	NP_783866.3	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020