DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ad and Serpinh1

DIOPT Version :9

Sequence 1:	NP_610261.1	Gene:	Spn43Ad / 35639	FlyBaseID:	FBgn0044011	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_058869.2	Gene:	Serpinh1 / 29345	RGDID:	69302	Length:	417	Species:	Rattus norvegicus

Alignment Length:	425	Identity:	100/425 - (23%)
Similarity:	180/425 - (42%)	Gaps:	45/425 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LSALLVG----LAIAL----------TLPVDGELLARSPASVSSNRFGLRLTTKLGLTQPDA--N 55
            :.:||:|    ||:||          |.|...|.|:....:::....||..:....:.:..|  |
  Rat     1 MRSLLLGTLCLLAVALAAEVKKPVEATAPGTAEKLSSKATTLAERSTGLAFSLYQAMAKDQAVEN 65

  Fly    56 VVVSPLLIQAALSLLYAESSSEYGSQLRQALELTHASHPKLAVQDFET----LLTDLKQSAAIGC 116
            :::|||::.::|.|:.....:...||.:..|     |..||..::..|    ||..|..|.|...
  Rat    66 ILLSPLVVASSLGLVSLGGKATTASQAKAVL-----SAEKLRDEEVHTGLGELLRSLSNSTARNV 125

  Fly   117 RLRLLSDLYAQQRFTFNFRNEFETLAARMGVGCH--RLSWESASNAAQDIN-YAFLSRSNFSLGE 178
            ..:|.|.||...  :.:|.::| ..:::....|.  ::::....:|.|.|| :|    |..:.|:
  Rat   126 TWKLGSRLYGPS--SVSFADDF-VRSSKQHYNCEHSKINFRDKRSALQSINEWA----SQTTDGK 183

  Fly   179 LVSAPQLESLAEHNTPFLHVSGVTFRAPWAWAFDPTETQSINFFAGGNRPRLVDAMFGQHRYRYA 243
            |   |::....|.....|.|:.:.|:..|...|......:..|....:....|..|.....|.|.
  Rat   184 L---PEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVTMMHRTGLYNYY 245

  Fly   244 EVPALDAQLIEVPFATADLRMLIVFPNRPDGLAQLERKLAQSDLHQLRSQLEERKVALTLPKLRV 308
            :......||:|:|.|.....::|:.|:..:.|.:||:.|.:..|.....:::::.||::|||..|
  Rat   246 DDEKEKLQLVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKTWMGKMQKKAVAISLPKGVV 310

  Fly   309 LVHSDLKHVLEELGLAKLFTSEVHLSEVFSSILSSSAP-PLGAVVQSGLLELQEDGGNADDSFSF 372
            .|..||:..|..|||    |..:..::...|.:|.... .|.:|..:...|...:|...|.....
  Rat   311 EVTHDLQKHLAGLGL----TEAIDKNKADLSRMSGKKDLYLASVFHATAFEWDTEGNPFDQDIYG 371

  Fly   373 GDLFRRALPLVINHPFFYAIGNGK--TLLLSGHIV 405
            .:..|.......:|||.:.:.:.:  :||..|.:|
  Rat   372 REELRSPKLFYADHPFIFLVRDNQSGSLLFIGRLV 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ad	NP_610261.1	SERPIN	35..404	CDD:238101	88/380 (23%)
Serpinh1	NP_058869.2	serpinH1_CBP1	35..416	CDD:381003	90/391 (23%)
Serpinh1	NP_058869.2	Prevents secretion from ER. /evidence=ECO:0000305	414..417
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010