DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn43Ad and Serpinb8

DIOPT Version :9

Sequence 1:	NP_610261.1	Gene:	Spn43Ad / 35639	FlyBaseID:	FBgn0044011	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_001099418.1	Gene:	Serpinb8 / 288937	RGDID:	1309833	Length:	375	Species:	Rattus norvegicus

Alignment Length:	398	Identity:	90/398 - (22%)
Similarity:	165/398 - (41%)	Gaps:	64/398 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SSNRFGLRLTTKLGLTQPDANVVVSPLLIQAALSLLYAESSSEYGSQLRQALELT-----HASHP 94
            ::..|.:.|...||......|:...|:.:.:||:::|..:.....:|:.|.|.|:     |
  Rat     7 ANGSFAISLLKILGEEDKSRNLFFCPMSVSSALAMVYLGAKGNTATQMSQVLGLSGDGDVH---- 67

  Fly    95 KLAVQDFETLLTDLKQSAA-----IGCRLRLLSDLYAQQRFTFNFRNEF-ETLAARMGVGCHRLS 153
                |.|:|||.::.:|..     ..||      |:.::  :.:|.:.| |:.......|...:|
  Rat    68 ----QGFQTLLAEVNKSGTQYLLKSACR------LFGEE--SCDFLSTFKESCQKFYQAGIEEMS 120

  Fly   154 W-ESASNAAQDINYAFLSRSNFSLGELVSAPQLESLAEHNTPFLHVSGVTFRAPWAWAFDPTETQ 217
            : :......:.||...|.::...:.|::|...:..|    |..:.|:.:.|:..|...||...|:
  Rat   121 FVKDTEGCRKRINDWVLEKTEGKISEVLSPGTVCPL----TKLVLVNAMYFKGKWKAQFDRKYTR 181

  Fly   218 SINFFAGGNRPRLVDAMFGQHRYRYAEVPALDAQLIEVPFATADLRMLIVFPNRPDGLAQLERKL 282
            .:.|.......:.|..||...:::.|.|..::||::.:|:|..:|.|:::.|:....|..:|:.|
  Rat   182 GMPFKTNQEEKKTVQMMFKHAKFKMAHVDEVNAQVLALPYAEDELSMVVLLPDESSDLTVVEKAL 246

  Fly   283 AQSDLHQLRS--QLEERKVALTLPKLRVLVHSDLKHVLEELGLAKLFTSEVHLSEVFSSILSSSA 345
            ....|....:  .|.|.||.:..|:|::....||:.||:.||:...|.   .....||.:.|...
  Rat   247 TYEKLRAWTNPETLTESKVQVFFPRLKLEESYDLETVLQSLGMTDAFE---ETKADFSGMTSKKN 308

  Fly   346 PPLGAVVQSGLLELQEDGGNADDSFSFGDLFRRALPLVI--------------NHPFFYAIGNGK 396
            .|:..|.....:|:.|:|..|           .|...||              :.||.:.|.:.|
  Rat   309 VPVSKVAHKCFVEVNEEGTEA-----------AATTAVIRNTRSCRIEPRFCADRPFLFFIWHQK 362

  Fly   397 T--LLLSG 402
            |  :|..|
  Rat   363 TSSILFCG 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ad	NP_610261.1	SERPIN	35..404	CDD:238101	90/398 (23%)
Serpinb8	NP_001099418.1	SERPIN	4..375	CDD:294093	90/398 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920