DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ad and Serpine2

DIOPT Version :9

Sequence 1:	NP_610261.1	Gene:	Spn43Ad / 35639	FlyBaseID:	FBgn0044011	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_033281.1	Gene:	Serpine2 / 20720	MGIID:	101780	Length:	397	Species:	Mus musculus

Alignment Length:	397	Identity:	83/397 - (20%)
Similarity:	169/397 - (42%)	Gaps:	34/397 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VDGELLARSPASVSSNRFGLRLTTKLGLTQPDANVVVSPLLIQAALSLLYAESSSEYGSQLRQAL 86
            |..:..:.|...:.||. |:::..::..::|..||||||..|.:.|.:|...:..:...||...:
Mouse    18 VHSQFNSLSLEELGSNT-GIQVFNQIIKSRPHENVVVSPHGIASILGMLQLGADGKTKKQLSTVM 81

  Fly    87 ELTHASHPKLAVQDFETLLTDL-KQSAAIGCRLRLLSDLYAQQRFTFNFRNEFETLAARMGVGC- 149
            ........|:..:..:.:::.. |....:...:.|.:....:..|....::.|:         |
Mouse    82 RYNVNGVGKVLKKINKAIVSKKNKDIVTVANAVFLRNGFKMEVPFAVRNKDVFQ---------CE 137

  Fly   150 -HRLSWESASNAAQDINYAFLSRSNFSLGELVSAPQLESLAEHNTPFLHVSGVTFRAPWAWAFDP 213
             ..::::..::|::.||:...:.:...:..|:|...::...   |..:.|:.|.|:..|...|.|
Mouse   138 VQNVNFQDPASASESINFWVKNETRGMIDNLLSPNLIDGAL---TRLVLVNAVYFKGLWKSRFQP 199

  Fly   214 TETQSINFFAGGNR----PRLVDAMFGQHRYRYAEVP-ALDAQLIEVPFATADLRMLIVFPNRPD 273
            ..|:...|.||..:    |.|  |.....|......| .|....||:|:....:.|||..|....
Mouse   200 ESTKKRTFVAGDGKSYQVPML--AQLSVFRSGSTRTPNGLWYNFIELPYHGESISMLIALPTESS 262

  Fly   274 -GLAQLERKLAQSDLHQLRSQLEERKVALTLPKLRVLVHSDLKHVLEELGLAKLF-TSEVHLSEV 336
             .|:.:...:....:....:.:..:::.|.|||...:..:|||..|:.||:.::| .|:.:
Mouse   263 TPLSAIIPHITTKTIDSWMNTMVPKRMQLVLPKFTAVAQTDLKEPLKALGITEMFEPSKAN---- 323

  Fly   337 FSSILSSSAPPLGAVVQSGLLELQEDGGNADDSFSFGDLFRRALP--LVINHPFFYAIGNGKT-- 397
            |:.|..|.:..:..::|...:|:.|||..| .:.:...|..|:.|  .:::.||.::|.:..|
Mouse   324 FTKITRSESLHVSHILQKAKIEVSEDGTKA-SAATTAILIARSSPPWFIVDRPFLFSIRHNPTGA 387

  Fly   398 LLLSGHI 404
            :|..|.:
Mouse   388 ILFLGQV 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ad	NP_610261.1	SERPIN	35..404	CDD:238101	81/382 (21%)
Serpine2	NP_033281.1	serpinE2_GDN	21..395	CDD:381039	82/394 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020