Protein Alignment Spn43Ad and Serpina12

DIOPT Version :10

• Sequence 1: NP_610261.1
• Gene: Spn43Ad / 35639
• FlyBaseID: FBgn0044011
• Length: 407
• Species: Drosophila melanogaster
• Sequence 2: NP_620180.2
• Gene: Serpina12 / 191570
• RGDID: 708485
• Length: 414
• Species: Rattus norvegicus
• Alignment Length: 422
• Identity: 103/422 - (24%)
• Similarity: 175/422 - (41%)
• Gaps: 75/422 - (17%)

  Fly    12 VGLAIALTLPVDGELLAR-------SPASVSSNR--------------FGLRLTTKLGLTQPDAN 55
            :||.:|..|.|.|.|..|       ||..|...|              ||.:|..:|.......|
  Rat     7 LGLFLAGLLTVKGLLQDRDAPDTYESPVRVQEWRGKKDARELTRHNMEFGFKLLQRLASNSRQGN 71

  Fly    56 VVVSPLLIQAALSLLYAESSSEYGSQLRQALELTHAS--------HPKLAVQDFETLLTDLKQSA 112
            :.:|||.|..|.|:|...:.:....::|:.......|        |..|...:.||  .|:|.|
  Rat    72 IFLSPLSISTAFSMLSLGAQNSTLEEIREGFNFKEMSDRDMHMGFHYLLQKLNRET--QDVKMS- 133

  Fly   113 AIGCRLRLLSDLYAQQRFTFNFRNEFETLAARMGVGCHRLSWESASNAAQDINYAFLSRSNFSLG 177
             ||..|.:...|..||||....:|.::   |.|.:    .:::...|..::|| .::||...:
  Rat   134 -IGNALFMDQRLRPQQRFLKLAKNLYD---ADMIL----TNFQDLENTQKNIN-KYISRKTHN-- 187

  Fly   178 ELVSAPQLESLAEH---NTPFLHVSGVTFRAPWAWAFDPTETQSINFFAGGNRPRLVDAMFGQHR 239
                  ::|::.::   .|..|..:.:.|:..|.:.|||.:|:..:||....:...|..||.:..
  Rat   188 ------RIENMVKNIDPGTVMLLTNYIYFQGRWQYEFDPKQTKEEDFFIEEGKTVKVPMMFQRGM 246

  Fly   240 YRYAEVPALDAQLIEVPFATADLRMLIVFPNRPDGLAQLERKLAQSDLH-QLRSQLEERKVALTL 303
            |..|....|...::|:|: ..::....|.|:  .|..:|..:..|:|:. :.:|.|.:|.|.:.:
  Rat   247 YDMAYDSQLSCTILEMPY-RRNITATFVLPD--SGKLRLLEQGLQADIFAKWKSLLSKRVVDVWV 308

  Fly   304 PKLRVLVHSDLKHVLEELGLAKLFTSEVHLSEVFSSILSSSAPPLGAVVQSGLLELQEDG--GNA 366
            |:|.:....::|.||..||::|:|.....|:.    |.|..:..:|..|....|.:.|.|  |.|
  Rat   309 PRLHISATYNMKKVLSRLGISKIFEEHGDLTR----ISSHRSLKVGEAVHKAELRMNEKGTEGAA 369

  Fly   367 DDSFSFGDLFRRALP------LVINHPFFYAI 392
            ...       .:.||      :.:|.||...|
  Rat   370 GSG-------AQTLPMETPRRMKLNAPFLMMI 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ad	NP_610261.1	serpin42Dd-like_insects	34..407	CDD:381070	93/393 (24%)
Serpina12	NP_620180.2	serpinA12_vaspin	40..411	CDD:381026	92/389 (24%)
		Reactive center loop. /evidence=ECO:0000250|UniProtKB:Q8IW75	364..382		5/24 (21%)