DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ad and Serpind1

DIOPT Version :9

Sequence 1:	NP_610261.1	Gene:	Spn43Ad / 35639	FlyBaseID:	FBgn0044011	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_001317976.1	Gene:	Serpind1 / 15160	MGIID:	96051	Length:	478	Species:	Mus musculus

Alignment Length:	387	Identity:	87/387 - (22%)
Similarity:	157/387 - (40%)	Gaps:	45/387 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 FGLRLTTKLGLTQPDANVVVSPLLIQAALSLLYAESSSEYGSQLRQAL---ELTHASHPKLAVQD 100
            |.|....|...|..| |:.::|:.|..|:.::......|...::...|   :..:|| .|..|..
Mouse   114 FNLYRVLKDQATTSD-NLFIAPVGISTAMGMISLGLRGETHEEVHSVLHFRDFVNAS-SKYEVTT 176

  Fly   101 FETL---LTDLKQSAAIGCRLRLLSDLYAQQRFTFNFRNEFETLAARMGVGCHRLSWESASNAAQ 162
            ...|   ||........|..||.::.||.|::|.  .|.:|:. |.|          |.....||
Mouse   177 IHNLFRKLTHRLFRRNFGYTLRSVNGLYIQKQFP--IREDFKA-AMR----------EFYFAEAQ 228

  Fly   163 DINY---AFLSRSNFSLGELVSAPQLESL--AEHNTPFLHVSGVTFRAPWAWAFDPTETQSINFF 222
            :.|:   ||:|::|..:.:|......|:|  .:..|..|.::.:.|:..|...|....|.:.||.
Mouse   229 EANFPDPAFISKANNHILKLTKGLIKEALENIDPATQMLILNCIYFKGTWVNKFPVEMTHNHNFR 293

  Fly   223 AGGNRPRLVDAMFGQHRYRYAEVPALDAQLIEVPFATADLRMLIVFPNRPDGLAQLERKLAQSDL 287
            ........|..|..:..:..|....||..::::.: ...:.||||.|.:..|:..||.:|....:
Mouse   294 LNEREVVKVSMMQTKGNFLAANDQELDCDILQLEY-VGGISMLIVVPRKLSGMKTLEAQLTPQVV 357

  Fly   288 HQLRSQLEERKVALTLPKLRVLVHSDLKHVLEELGLAKLFTSEVHLSEVFSSILSSSAPPLGAVV 352
            .:.:..:..|...:.|||.::..:.:|..||:.:|:.|||....::|.:     |.....:....
Mouse   358 ERWQKSMTNRTREVLLPKFKLEKNYNLVEVLKSMGITKLFNKNGNMSGI-----SDQRIAIDLFK 417

  Fly   353 QSGLLELQEDGGNADDSFSFGDLFRRALPL------VINHPFFYAIGNGKT--LLLSGHIVD 406
            ....:.:.|:|..|....:.|     .:||      .::.||.:.:...:|  ||..|.:.:
Mouse   418 HQSTITVNEEGTQAAAVTTVG-----FMPLSTQVRFTVDRPFLFLVYEHRTSCLLFMGKVTN 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ad	NP_610261.1	SERPIN	35..404	CDD:238101	87/383 (23%)
Serpind1	NP_001317976.1	HCII	43..476	CDD:239002	87/387 (22%)
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	54..78
		Glycosaminoglycan-binding site. /evidence=ECO:0000250	171..191		5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110