DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ad and Serping1

DIOPT Version :9

Sequence 1:	NP_610261.1	Gene:	Spn43Ad / 35639	FlyBaseID:	FBgn0044011	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_033906.2	Gene:	Serping1 / 12258	MGIID:	894696	Length:	504	Species:	Mus musculus

Alignment Length:	409	Identity:	99/409 - (24%)
Similarity:	166/409 - (40%)	Gaps:	78/409 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ALTLPVDGELLAR--------SPASVSS--NRFGLRL-----TTKLGLTQPDANVVVSPLLIQAA 66
            |.|.|...|.||:        |.|.:|.  ..|.::|     .||:..|    |:..||..|.:.
Mouse   122 ATTEPFCPEPLAQCSDSDRDSSEAKLSEALTDFSVKLYHAFSATKMAKT----NMAFSPFSIASL 182

  Fly    67 LSLLYAESSSEYGSQLRQALELTHASHPKLAVQDFETLLTDLKQSAAIGCRLRLLSDLYAQQRFT 131
            |:.:...:.....|.|...|     |:||    ||..:...||..::.|  :..:|.::......
Mouse   183 LTQVLLGAGDSTKSNLESIL-----SYPK----DFACVHQALKGFSSKG--VTSVSQIFHSPDLA 236

  Fly   132 F--NFRNEFETLAARMGVGCHRLSWESASNAAQDINYAFLSRSNFSLGELVSAPQLESLAEHNTP 194
            .  .:.|..::|   .|.....|..:||:| .:.||......:|..:.:|     |:||.. :|.
Mouse   237 IRDTYVNASQSL---YGSSPRVLGPDSAAN-LELINTWVAENTNHKIRKL-----LDSLPS-DTC 291

  Fly   195 FLHVSGVTFRAPWAWAFDPTETQSINFFAGG-------NRPRLVDAMFGQHRYRYAEVPALDAQL 252
            .:.::.|...|.|...|:|.:..:..|:...       :..:...|.|..|..: |:|..|  ||
Mouse   292 LVLLNAVYLSAKWKITFEPKKMMAPFFYKNSMIKVPMMSSVKYPVAQFDDHTLK-AKVGQL--QL 353

  Fly   253 IEVPFATADLRMLIVFPNRP-DGLAQLERKLAQSDLHQLRSQLEERK---VALTLPKLRVLVHSD 313
                  :.:|..:||.|..| ..|..:|:.|..:....:..:||..|   ..||:|.::|....|
Mouse   354 ------SHNLSFVIVVPVFPKHQLKDVEKALNPTVFKAIMKKLELSKFLPTYLTMPHIKVKSSQD 412

  Fly   314 LKHVLEELGLAKLFTSEVHLSEVFSSILSSSAPPL--GAVVQSGLLELQEDG--GNADDSFSFGD 374
            :..|:|:|.... ||.:::|..:      :..|.|  .|:....:|||.|.|  ..|..:.|||
Mouse   413 MLSVMEKLEFFD-FTYDLNLCGL------TEDPDLQVSAMKHETVLELTESGVEAAAASAISFG- 469

  Fly   375 LFRRALPLV-INHPFFYAI 392
               |:||:. :..||.:.:
Mouse   470 ---RSLPIFEVQRPFLFLL 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ad	NP_610261.1	SERPIN	35..404	CDD:238101	91/383 (24%)
Serping1	NP_033906.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..67
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..141		6/18 (33%)
		serpinG1_C1-INH	141..500	CDD:381006	93/390 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100