DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9b2 and CYP4F12

DIOPT Version :9

Sequence 1:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_076433.3	Gene:	CYP4F12 / 66002	HGNCID:	18857	Length:	524	Species:	Homo sapiens

Alignment Length:	545	Identity:	123/545 - (22%)
Similarity:	211/545 - (38%)	Gaps:	93/545 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ICLALVVIGYL---IYKWSTATFKTFEERKLYFEKPYP-----FVGNMAAAALQKSSFQR--QLT 60
            :.|.|||..:|   |..|:.|.:......:.:   |.|     |.|::......:...:.  |::
Human    20 LLLLLVVGSWLLARILAWTYAFYNNCRRLQCF---PQPPKRNWFWGHLGLITPTEEGLKNSTQMS 81

  Fly    61 EFYERTRQHKLVGF---FNMRTPMITLNDPELIKKVCVKDFDHFPNHQPFITSNDRLF------- 115
            ..|.:       ||   .....|.|.|..|:.|:.:        .|....|...|.||
Human    82 ATYSQ-------GFTVWLGPIIPFIVLCHPDTIRSI--------TNASAAIAPKDNLFIRFLKPW 131

  Fly   116 -NDMLSVMRDQRWKHMRNTLTPVFTAAKMRNMFTLMNES---FAECLQHLDSSSKTLPGRKGFEV 176
             .:.:.:....:|...|..|||.|....:::..|:.|:|   ..:..|||.|...:       .:
Human   132 LGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSS-------RL 189

  Fly   177 DMKVMCNKLSNDIIATTAFGLKVNSYDNPKNEFYEIGQ--SLVFSRGLQFFKFMLSTLVPKLFSL 239
            ||....:.::.|.:....|....:..:.|......|.:  :||..|.....:.|         ..
Human   190 DMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQHM---------DF 245

  Fly   240 LKLTIFDSAKVDYFARLVVEAMQ------------------YREKHNITRPDMIQLLMEAKNESE 286
            |.....|..:.....|||.:...                  :::|......|.|.:|:.:|:|..
Human   246 LYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDG 310

  Fly   287 DKWTDDEIVAQCFIFFFAAFENNSNLICTTTYELLYNPDVQERLYEEIVETKKALNGAPLTYDAV 351
            ...:|::|.|:...|.|...:..::.:....|.|..:|:.|||..:|:.|..|..:...:.:|.:
Human   311 KALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDL 375

  Fly   352 QKMTYMDMVISESLRKWTLAAATDRLCSKDYTLTDDDGTKLFDFKVGDRINIPISGLHLDDRYFP 416
            .::.::.|.:.||||....|....|.|::|..|  .||..:   ..|....|.|.|:|.:...:|
Human   376 AQLPFLTMCVKESLRLHPPAPFISRCCTQDIVL--PDGRVI---PKGITCLIDIIGVHHNPTVWP 435

  Fly   417 EPRKFDPDRFSEERKGDMVPYTYLPFGVGPRNCIGNRYALMQVKGMLFNLLLHYKI---EASPRT 478
            :|..:||.||..|......|..::||..|||||||..:|:.::|.:|..:|||::.   ...||.
Human   436 DPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRR 500

  Fly   479 IKDLWGSASGFNFTPRSGFWMHLVP 503
            ..:|...|.|       |.|:.:.|
Human   501 KLELIMRAEG-------GLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	108/484 (22%)
CYP4F12	NP_076433.3	p450	52..506	CDD:306555	110/489 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810