DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9b2 and cyp3c4

DIOPT Version :9

Sequence 1:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_001071016.1	Gene:	cyp3c4 / 558541	ZFINID:	ZDB-GENE-060929-96	Length:	507	Species:	Danio rerio

Alignment Length:	530	Identity:	150/530 - (28%)
Similarity:	263/530 - (49%)	Gaps:	58/530 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALIEICLALVVIGY-LIYKWSTATFKTFEERKLYFEKPYPFVGNMAAAALQKSSFQRQLTEFYE 64
            ::.:.:...|||:.. |::.:.....:.|.:..:...:|:||||.:.:.|....:|..:..:.|
Zfish     4 LSFLSVTWTLVVLVITLLFIYGVWPHRFFIKLGIPGPRPWPFVGTLLSYAKGLCNFDMECAKKY- 67

  Fly    65 RTRQHKLVGFFNMRTPMITLNDPELIKKVCVKD-FDHFPNHQPFITSNDRLFNDMLSVMRDQRWK 128
                .|:.|.::.|.|::.:.|.|:||.|.||: :.:|.|.:...|.....|:|.:.:::|:|||
Zfish    68 ----GKVWGIYDGRLPILMVADLEVIKVVLVKECYSNFINRRKRTTGLAGPFSDGIIMVKDERWK 128

  Fly   129 HMRNTLTPVFTAAKMRNMFTLMNESFAECLQHLDSSSKTLPGRKGFE--VDMKVMCNKLSNDIIA 191
            .||:||:|.||:.:::.:|.:       .:.|.|...|.:. :|..|  |.:|.:....|.|:|.
Zfish   129 RMRSTLSPYFTSGRLKEIFPI-------AMTHADRFIKNMQ-KKDPEQPVKIKEVVAPYSLDVIT 185

  Fly   192 TTAFGLKVNSYDNPKNEFYEIGQSLVFSRGLQFFKF----MLSTLVPKLFSLLK---LTIFDSAK 249
            :::|.:.::|.:||::.|.     :...:.:||..|    :|..|.|.|...||   :|:|..:.
Zfish   186 SSSFSVDIDSINNPEDPFV-----INVKKFIQFNMFNPLLLLILLFPSLAIPLKKMGVTLFSKSA 245

  Fly   250 VDYFARLVVEAMQYREKHNITRPDMIQLLMEAK---NESEDK---------WTDDEIVAQCFIFF 302
            :|:|..::.:......|.:..|.|.::|:::.:   ::.:|.         .||.||::|..:|.
Zfish   246 MDFFYSVLKKIKDDHNKESEGRVDFLKLMLQNQIPDDQIQDSDTSEQPAKGLTDHEILSQSLVFI 310

  Fly   303 FAAFENNSNLICTTTYELLYNPDVQERLYEEIVETKKALNGAPLTYDAVQKMTYMDMVISESLRK 367
            ...:|..|..:....|.|..|||..|:|.|||  .|......|:||||:.:|.|::|.|:||:|.
Zfish   311 LGGYETTSTTLTFLLYNLATNPDCLEKLVEEI--DKNFPLDTPITYDALMRMDYLEMAINESMRL 373

  Fly   368 WTLAAATDRLCSKDYT---LTDDDGTKLFDFKVGDRINIPISGLHLDDRYFPEPRKFDPDRFSEE 429
            ...|...:|...|...   ||..:||         .:.||...|..|...:..|.:|.|:|||.|
Zfish   374 LPTAPRLERSAKKTVVINGLTIPEGT---------LVGIPTYVLSHDPDIWESPGEFRPERFSPE 429

  Fly   430 RKGDMVPYTYLPFGVGPRNCIGNRYALMQVKGMLFNLLLHYKIEASPRTIKDLWGSASGFNFTPR 494
            .|.:.:.|.::|||:|||||||.|||:|.:|..:..||.::.:|....|...|   .....|.|:
Zfish   430 NKSEFLQYAFIPFGLGPRNCIGMRYAVMIMKLFVVKLLQNFSVETCKETQIPL---EMNVTFQPK 491

  Fly   495 SGFWMHLVPR 504
            ....:.|:||
Zfish   492 VPITLKLIPR 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	138/465 (30%)
cyp3c4	NP_001071016.1	p450	38..485	CDD:278495	140/478 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	238	1.000	Inparanoid score	I3329
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.770