DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9b2 and Cyp3a73

DIOPT Version :9

Sequence 1:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	XP_038945885.1	Gene:	Cyp3a73 / 498198	RGDID:	1595705	Length:	504	Species:	Rattus norvegicus

Alignment Length:	523	Identity:	180/523 - (34%)
Similarity:	276/523 - (52%)	Gaps:	56/523 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IEICLALVVIGYLIYKWSTATFKTFEERKLYFEKPYPFVGNMAAAALQKSSFQRQLTEF----YE 64
            :|..|.|.:|..|.|::.|.|...|:::.:...||.||:|.:.       ::.|.|.:|    |:
  Rat     9 LETWLLLAIILVLFYRFGTRTHGIFKKQGIPGPKPLPFLGTVL-------NYYRGLWKFDMECYK 66

  Fly    65 RTRQHKLVGFFNMRTPMITLNDPELIKKVCVKD-FDHFPNHQ---PFITSNDRLFNDMLSVMRDQ 125
            :.  .|:.|.|:.:||:..:.|.|:||.|.||: |..|.|.:   |.     .:.:..:||.:|:
  Rat    67 KC--GKIWGLFDGQTPVFAIMDTEMIKSVLVKECFSVFTNRRNIGPV-----GIMSKSISVAKDE 124

  Fly   126 RWKHMRNTLTPVFTAAKMRNMFTLMNESFAECL-QHLDSSSKTLPGRKGFEVDMKVMCNKLSNDI 189
            .||..|..|:|.||:.:::.||.:: |.:.:.| ::|....:     ||..:.||.:....|.|:
  Rat   125 EWKRYRAFLSPTFTSGRLKEMFPII-EHYGDILVKYLKQKVE-----KGKPLAMKEVFGAYSMDV 183

  Fly   190 IATTAFGLKVNSYDNPKNEFYEIGQSLVFSRGLQFFK--FMLSTLVP---KLFSLLKLTIFDSAK 249
            |.:|:|.:.:||.:|||:.|.|  :...|.| ..||.  |:...|.|   .::.:|.:.:|....
  Rat   184 ITSTSFEVNINSINNPKDPFVE--KVKKFQR-FDFFDPLFLSVVLFPFLTPIYEMLNICLFPKDS 245

  Fly   250 VDYFARLVVEAMQYR--EKHNITRPDMIQLLMEAKNESEDK-----WTDDEIVAQCFIFFFAAFE 307
            |.:|.:.|....|.|  .||. .|.|.:||:|.|.|.|:||     .:|.|||||..||.||::|
  Rat   246 VAFFQKFVYRMKQTRLDSKHK-HRVDFLQLMMNAHNNSKDKVSHKALSDIEIVAQAIIFIFASYE 309

  Fly   308 NNSNLICTTTYELLYNPDVQERLYEEIVETKKAL-NGAPLTYDAVQKMTYMDMVISESLRKWTLA 371
            ..|:.:....|.|..:||.|::|.|||   .:|| |.||.|||.|.:|.|:|||::|:.|.:.:.
  Rat   310 TTSSTLSFVLYSLATHPDSQKKLQEEI---DRALPNKAPPTYDTVMEMEYLDMVLNETPRLYPIG 371

  Fly   372 AATDRLCSKDYTLTDDDGTKLFDFKVGDRINIPISGLHLDDRYFPEPRKFDPDRFSEERKGDMVP 436
            ...:|:|.||..|   ||..:   ..|..:.||...|..|.:::|||.:|.|:|||:|.||.:.|
  Rat   372 YRLERVCKKDIKL---DGVFI---PKGSVVMIPFYTLQHDPQHWPEPEEFLPERFSKENKGSIDP 430

  Fly   437 YTYLPFGVGPRNCIGNRYALMQVKGMLFNLLLHYKIEASPRTIKDLWGSASGFNFTPRSGFWMHL 501
            |.|||||.|||||||.|:|||.:|..|..:|.::..:....|...|..|.... |.|.....:.:
  Rat   431 YVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQLCEETQIPLKLSRQRL-FGPEKPIVLKV 494

  Fly   502 VPR 504
            |||
  Rat   495 VPR 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	163/462 (35%)
Cyp3a73	XP_038945885.1	CYP3A	67..493	CDD:410743	159/452 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010