DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9b2 and Cyp6d2

DIOPT Version :9

Sequence 1:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_611698.1	Gene:	Cyp6d2 / 37594	FlyBaseID:	FBgn0034756	Length:	512	Species:	Drosophila melanogaster

Alignment Length:	502	Identity:	144/502 - (28%)
Similarity:	245/502 - (48%)	Gaps:	50/502 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ICLALVVIGYLIYKWSTATFKTFEERKLYFEKP--YPFVGNMAAAALQKSSFQRQLTEFYERTRQ 68
            |.|.:::.| |:|::....: |..:|....|:|  .|| |.|.....|:.|....|.:.|.| .:
  Fly     4 ILLTILIAG-LLYRYVKRHY-THWQRLGVDEEPAKIPF-GVMDTVMKQERSLGMALADIYAR-HE 64

  Fly    69 HKLVGFFNMRTPMITLNDPELIKKVCVKDFDHFPNHQPFITSND-----RLFNDMLSVMRDQRWK 128
            .|:||.:.:....|.:.|.:|.:::...||..|.:...::..:.     .|||     :|...|:
  Fly    65 GKIVGIYMLNKRSILIRDAQLARQIMTSDFASFHDRGVYVDEDKDPLSANLFN-----LRGASWR 124

  Fly   129 HMRNTLTPVFTAAKMRNMFTLMNESFAECLQHLDSSSKTLPGRKGFEVDMKVMCNKLSNDIIATT 193
            ::|..|||.|::.|::.||..:::...:.:|||:.:..     :..||::|.:....:.|||.:.
  Fly   125 NLRQKLTPSFSSGKIKGMFGTIDDVGDKLVQHLEGALD-----QSDEVEIKDVMTTYAVDIIGSV 184

  Fly   194 AFGLKVNSYDNPKNEFYEIGQSLVFSRGLQFFKFMLSTLV-PKLFSLLKLTIFDSAKVDYFARLV 257
            .|||:::|:.||||||.||..|......|......:|..: |.:..|:....::|..:.....::
  Fly   185 IFGLEIDSFRNPKNEFREISSSTSRDESLLLKIHNMSMFICPPIAKLMNRLGYESRILTSLRDMM 249

  Fly   258 VEAMQYREKHNITRPDMIQLLMEAKN-----ESEDKWTD-------------DEIVAQCFIFFFA 304
            ...:::||:||:.|.||:|||:..:|     |.:|:..|             ::|.||.|:|:.|
  Fly   250 KRTIEFREEHNVVRKDMLQLLIRLRNTGKIGEDDDQVWDMETAQEQLKSMSIEKIAAQAFLFYVA 314

  Fly   305 AFENNSNLICTTTYELLYNPDVQERLYEEIVETKKALNGAP---LTYDAVQKMTYMDMVISESLR 366
            ..|:.:.....|.|||...|::.:...||:.......|..|   .||:|||.:.::|:.|.|::|
  Fly   315 GSESTAAASAFTLYELSMYPELLKEAQEEVDAVLMKHNLKPKDRFTYEAVQDLKFLDICIMETIR 379

  Fly   367 KWTLAAATDRLCSKDYTLTDDDGTKLFDFKVGDRINIPISGLHLDDRYFPEPRKFDPDRF-SEER 430
            |:......:|.|::||.:   .||.....| |..|.|.:.|:..|..|||.|..:||.|| |...
  Fly   380 KYPGLPFLNRECTEDYPV---PGTNHIIAK-GTPILISLFGMQRDPVYFPNPNGYDPHRFDSNNM 440

  Fly   431 KGDMVPYTYLPFGVGPRNCIGNRYALMQVKGMLFNLLLHYKIEASPR 477
            ..|..  .|:|||.|||:||..|...:..|..:..:|.::.:..|||
  Fly   441 NYDQA--AYMPFGEGPRHCIALRMGKVNSKVAVAKILANFDLVQSPR 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	136/471 (29%)
Cyp6d2	NP_611698.1	p450	65..506	CDD:278495	126/437 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461139
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900