DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9b2 and Cyp4e2

DIOPT Version :9

Sequence 1:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	492	Identity:	106/492 - (21%)
Similarity:	208/492 - (42%)	Gaps:	54/492 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IEICLALVVIGYLIYKWSTATFKTFEERKLY--FEKP--YPFVGNMAAAALQKSSFQRQLTEFYE 64
            |.:.|.|:::.||       ...||..|::.  |..|  .|.:||........|.....:..::.
  Fly     7 IFLALPLLLVAYL-------ELSTFRRRRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWWH 64

  Fly    65 RTRQHKLVGFFNMRTPMITLNDPELIKKVCVKDFDHFPNHQPFITSND--RLFNDMLSV----MR 123
            :..:...|.:....:.::..:.         |..:...:.|..||.:|  :|.:..|.:    ..
  Fly    65 QYGKDNFVFWIGTYSNVLVTSS---------KYLEFILSSQTLITKSDIYQLTHPWLGLGLLTST 120

  Fly   124 DQRWKHMRNTLTPVFTAAKMRNMFTLMNESFAECLQHLDSSSKTLPGRKGFEVDMKVMCNKLSND 188
            ..:|...|..:||.|....:::...:|||:..:.::||    ||:...... .|.:...:.|:.|
  Fly   121 GSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHL----KTVAAGDNI-FDFQEQAHYLTLD 180

  Fly   189 IIATTAFGLKVNSYDNPKNEFYEIGQSLVFSRGLQFF-----KFMLSTLVP--KLFSLLKLTIFD 246
            :|..||.|:.:|:.:|..:...:..:.:.::..::.|     ..:|..|.|  ..:|....|:.|
  Fly   181 VICDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQD 245

  Fly   247 SAKVDYFARLVVE---AMQYREKHNITRPDM--IQLLMEAKNESEDKWTDDEIVAQCFIFFFAAF 306
            ........|:...   |:........||..|  :..|:.:..:.. .....|:..:...|.|...
  Fly   246 FTNEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLDTLLSSTIDGR-PLNSKELYEEVSTFMFEGH 309

  Fly   307 ENNSNLICTTTYELLYNPDVQERLYEEIVETK-KALNGAPLTYDAVQKMTYMDMVISESLRKWTL 370
            :..::.:....|.|..:.|.|.:|::|..|.. .:..|...|:..:.:|.|:|:.|.|:.|.:..
  Fly   310 DTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVYPS 374

  Fly   371 AAATDRLCSKDYTLTDDDGTKLFDFKVGDRINIPISGLHLDDRYFPEPRKFDPDRFSEERKGDMV 435
            .....|...|||.:..|...|      |..:|:.:..|..:::.|.:|.||.|:||..|:.|
  Fly   375 VPFIGRFTEKDYVIDGDLVPK------GTTLNLGLVMLGYNEKVFKDPHKFRPERFELEKPG--- 430

  Fly   436 PYTYLPFGVGPRNCIGNRYALMQVKGMLFNLLLHYKI 472
            |:.|:||..|||||||.::||:::|.::..::.::::
  Fly   431 PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEV 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	97/457 (21%)
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	97/457 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810