DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9b2 and cyp3c1

DIOPT Version :9

Sequence 1:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_997838.1	Gene:	cyp3c1 / 324340	ZFINID:	ZDB-GENE-030131-3060	Length:	505	Species:	Danio rerio

Alignment Length:	527	Identity:	144/527 - (27%)
Similarity:	253/527 - (48%)	Gaps:	71/527 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LALVVIGYLIY-KWSTATFKTFEERKLYF--EKPYPFVGNMAAAALQKSSFQRQLTEFYERTRQH 69
            :.||:...||| .|....||     ||..  .:|.||||...:.:....:|..:.::.|     .
Zfish    14 VVLVITLLLIYGVWPHGFFK-----KLGIPGPRPLPFVGTALSYSKGICNFDIECSKKY-----G 68

  Fly    70 KLVGFFNMRTPMITLNDPELIKKVCVKD-FDHFPNHQPFITSNDRL---FNDMLSVMRDQRWKHM 130
            |:.|.::.|.|::.:.|.|:||.:.||| :..|.|.:   ..|..|   |.|.:::::|:||:.:
Zfish    69 KVWGIYDGRLPLLLVTDLEMIKTILVKDCYSTFTNRR---NMNPDLVGPFADGITLVKDERWRRI 130

  Fly   131 RNTLTPVFTAAKMRNMFTLMNESFAECLQHLDSSSKTLPGRKGFEVDMKVMCNKLSNDIIATTAF 195
            |::|:|.||:.:::.:|.:........:::::.....||      :.:|.:....|.|::|:::|
Zfish   131 RSSLSPYFTSGRLKEIFPIAMTHADRFIKNMEKKDPNLP------LKIKDVVAPYSLDVVASSSF 189

  Fly   196 GLKVNSYDNPKNEFYEIGQSLVFSRGLQFFK-------FMLSTLVPKLFSLLK---LTIFDSAKV 250
            .:..:|.:||.:.|....:|        ||.       |:|....|...:||.   :::|..:..
Zfish   190 SVDFDSINNPDDPFVTSIKS--------FFNINPLSPLFLLLAFCPSAANLLAKMGISVFSRSTT 246

  Fly   251 DYFARLVVEAMQYREKHNIT--RPDMIQLLME-----------AKNESEDKWTDDEIVAQCFIFF 302
            |::.:.:   .:.:::||.:  |.|.::|:::           |..:.....||.||::|.|||.
Zfish   247 DFYYKAL---RKIKDEHNESNGRVDFLKLMIQNQIPDDQVKDTASEQPVKGLTDHEILSQSFIFI 308

  Fly   303 FAAFENNSNLICTTTYELLYNPDVQERLYEEIVETKKALNGAPLTYDAVQKMTYMDMVISESLRK 367
            ...:|..|..:....|.|..|||..|:|.|||  .|......|:||||:.:|.|::|.|.||:|.
Zfish   309 LGGYETTSTTLSYLLYNLATNPDCLEKLVEEI--DKNFPLDIPITYDALMRMDYLEMAIHESMRV 371

  Fly   368 WTLAAATDRLCSKDYTLTDDDGTKLFDFKVGDRINIPISGLHLDDRYFPEPRKFDPDRFSEERKG 432
            :......:|:|.|...:..      ........:.||:..|..|...:..|.:|.|:|||.|.|.
Zfish   372 FPAGPRLERVCKKTVEING------ITIPKNTLVGIPLYVLSRDPDLWESPNEFKPERFSPESKT 430

  Fly   433 DMVPYTYLPFGVGPRNCIGNRYALMQVKGMLFNLLLHYKIEASPRTIKDLWGSASGFNFTPRSGF 497
            ::....::|||:|||||||.|:|||.:|.::..||..|.:|....|...:   ...|.|.|:...
Zfish   431 EINQCAFMPFGLGPRNCIGMRFALMMMKLLVVKLLQKYTVETCKETQIPV---QLNFFFQPKVPI 492

  Fly   498 WMHLVPR 504
            .:.|:||
Zfish   493 TLKLIPR 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	127/467 (27%)
cyp3c1	NP_997838.1	p450	38..496	CDD:278495	131/493 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	238	1.000	Inparanoid score	I3329
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.770