DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9b2 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_796281.1	Gene:	Cyp4f39 / 320997	MGIID:	2445210	Length:	532	Species:	Mus musculus

Alignment Length:	552	Identity:	113/552 - (20%)
Similarity:	208/552 - (37%)	Gaps:	110/552 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LVVIGYLIYKWSTATFKTFEERKLYFEK----PYP-----FVGNMAAAALQKSSFQRQLTEFYER 65
            |:::.:..::.....||.|.:.::...|    |.|     .:|:|:.....:...|.:....  .
Mouse    28 LLLVLFFFFRLLVRAFKLFSDFRITCRKLSCFPEPPGRHWLLGHMSMYLPNEKGLQNEKKVL--D 90

  Fly    66 TRQHKLVGFFNMRTPMITLNDPELIKKVCVKDFDHFPNHQPFITSNDRLFNDMLSVMRDQRWKHM 130
            |..|.::.:.....|::.|..|:.||.|........|..:.|.:.......|.|.:.:..:|...
Mouse    91 TMHHIILAWVGPFLPLLVLVHPDYIKPVLGASAAIAPKDEFFYSFLKPWLGDGLLISKGNKWSRH 155

  Fly   131 RNTLTPVFTAAKMRNMFTLMNE----SFAECLQHLDSSSKTLPGRKGFEVDMKVMCNKLSNDIIA 191
            |..|||.|....::....:.|:    ..|:..:||...|.|       ..||....:.::.|.:.
Mouse   156 RRLLTPAFHFDILKPYMKIFNQCTNIMHAKWRRHLAEGSVT-------SFDMFEHISLMTLDSLQ 213

  Fly   192 TTAFGLKVNSYDNPKNEFYEIGQSLVFSRGLQFFKFMLSTLVPKLFSLLKLTIFDSAK----VDY 252
            ...|     ||::...|                   .:|..:..:..|..|.:....:    :|:
Mouse   214 KCVF-----SYNSDCQE-------------------RMSDYISSIIELSALVVRRQYRLHHYLDF 254

  Fly   253 FARLVVEAMQYREK----HNITRP--------------------------DMIQLLMEAKNESED 287
            ...|..:..::|:.    ||.|..                          |.|.:|:.||:|...
Mouse   255 MYYLTADGRRFRQACDTVHNFTTEVIQERRQALRQQGAEAWLKAKQGKTLDFIDVLLLAKDEEGK 319

  Fly   288 KWTDDEIVAQCFIFFFAAFENNSNLICTTTYELLYNPDVQERLYEEIVETKKALNGAPLTYDAVQ 352
            :.:|::|.|:...|.|...:..|:.:....:.|...|:.||:..|||.|..|......|.:|.:.
Mouse   320 ELSDEDIRAEADTFMFEGHDTTSSGLSWALFNLAKYPEYQEKCREEIQEVMKGRELEELDWDDLT 384

  Fly   353 KMTYMDMVISESLRKWTLAAATDRLCSKDYTLTDDDGTKLFDFKV---GDRINIPISGLHLDDRY 414
            ::.:..|.|.||||::.......|.|::|        .||.|.:|   |....:.|.|.|.:...
Mouse   385 QLPFTTMCIKESLRQFPPVTLISRRCTED--------IKLPDGRVIPKGIICLVSIYGTHHNPIV 441

  Fly   415 FPEPRKFDPDRFSEERKGDMVPYTYLPFGVGPRNCIGNRYALMQVKGMLFNLLLHY--------K 471
            :|:.:.::|.||..:......|..::||..|||||||..:|:.:::.::...||.:        |
Mouse   442 WPDSKVYNPYRFDPDTPQQRSPLAFVPFSAGPRNCIGQSFAMAEMRVVVALTLLRFRLSVDRTHK 506

  Fly   472 IEASPRTIKDLWGSASGFNFTPRSGFWMHLVP 503
            :...|..|           ....:|.|:::.|
Mouse   507 VRRKPELI-----------LRTENGLWLNVEP 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	105/498 (21%)
Cyp4f39	NP_796281.1	p450	60..515	CDD:365848	105/506 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900