DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9b2 and Cyp4a3

DIOPT Version :9

Sequence 1:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	XP_038965516.1	Gene:	Cyp4a3 / 298423	RGDID:	631356	Length:	511	Species:	Rattus norvegicus

Alignment Length:	524	Identity:	115/524 - (21%)
Similarity:	213/524 - (40%)	Gaps:	106/524 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LIEICLAL--VVIGYLIYKWSTATFKTF-------------EERKLYFEKPYPFVGNMAAAALQK 52
            |:.:.|.|  .|..||..:|.....:.|             ::|:  |::...:|.....|.||.
  Rat    24 LLSLFLVLFKAVQFYLRRQWLLKALEKFPSTPSHWLWGHDLKDRE--FQQVLTWVEKFPGACLQW 86

  Fly    53 SSFQRQLTEFYE--------RTRQHKLVGFFNMRTP---------MITLNDPELIK--KVCVKDF 98
            .|..:.....|:        .....|..|.:....|         ::.||..:..:  ::....|
  Rat    87 LSGSKTRVLLYDPDYVKVVLGRSDPKASGIYQFLAPWIVSGTGYGLLLLNGKKWFQHWRMLTPAF 151

  Fly    99 DHFPNHQPFITSNDRLFNDMLSVMRDQRWKHMRNTLTP--VFTAAKMRNMFTLMNESFA-ECLQH 160
             |:...:|::    ::..|.:|:|.| :|:.:.:...|  :|....:..:.|:|..:|: :....
  Rat   152 -HYGILKPYV----KIMADSVSIMLD-KWEKLDDQDHPLEIFHYVSLMTLDTVMKCAFSHQGSVQ 210

  Fly   161 LDSSSKTLPGRKGFEVDMKVMCNKLSNDIIATTAFGLKVNSYDNPKNEFYEIGQSLVFS------ 219
            ||.:|::.              .|...|:...|.|.:        ::.||  |.|::::
  Rat   211 LDVNSRSY--------------TKAVEDLNNLTFFRV--------RSAFY--GNSIIYNMSSDGR 251

  Fly   220 ---RGLQFFKFMLSTLVPKLFSLLKLTIFDSAKVDYFARLVVEAMQYREKHNITRPDMIQLLMEA 281
               |..|    :.......:..:.|..:.:..          |..:.|:|.::   |.:.:|:.|
  Rat   252 LSRRACQ----IAHEHTDGVIKMRKAQLQNEE----------ELQKARKKRHL---DFLDILLFA 299

  Fly   282 KNESEDKWTDDEIVAQCFIFFFAAFENNSNLICTTTYELLYNPDVQERLYEEIVETKKAL-NGAP 345
            |.|.....:|:::.|:...|.|...:..::.|....|.|..:|:.|||..||:   :..| :|..
  Rat   300 KMEDGKSLSDEDLRAEVDTFMFEGHDTTASGISWVFYALATHPEHQERCREEV---QSILGDGTS 361

  Fly   346 LTYDAVQKMTYMDMVISESLRKWTLAAATDRLCSKDYTLTDDDGTKLFDFKVGDRINIPISGLHL 410
            :|:|.:.:::|..|.|.|:||.:....:..|..|...|.  .||..:   ..|....|.|.|||.
  Rat   362 VTWDHLDQISYTTMCIKEALRLYPPVPSVSRELSSPVTF--PDGRSI---PKGITTTILIYGLHH 421

  Fly   411 DDRYFPEPRKFDPDRFSEERKGDMVPYTYLPFGVGPRNCIGNRYALMQVKGMLFNLLLHYKIEAS 475
            :..|:|.|:.|||.|||.:  .....:.||||..|.|||||.::|:.::|..:...||.:::...
  Rat   422 NPSYWPNPKVFDPSRFSPD--SPRHSHAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPD 484

  Fly   476 PRTI 479
            |..|
  Rat   485 PTRI 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	104/472 (22%)
Cyp4a3	XP_038965516.1	CYP4B-like	69..506	CDD:410771	106/477 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900