DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9b2 and Cyp4a8

DIOPT Version :9

Sequence 1:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	XP_038965258.1	Gene:	Cyp4a8 / 266674	RGDID:	628846	Length:	510	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	128/529 - (24%)
Similarity:	211/529 - (39%)	Gaps:	107/529 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALIEICLALVVIGYLIYKWSTATFKTFEERKLYFEKPYP------FVGNMAAAALQKSSFQRQL 59
            :..::|...|.|: .|::|  ||.|.......|...:.:|      |.|: ..:.|....||..|
  Rat    16 LGFLQIATVLTVL-LLLFK--TAQFYLHRRWLLRATQQFPSPPSHWFFGH-KLSFLVDQEFQDIL 76

  Fly    60 TEFYERTRQHKLVGFFNMRTPM--------ITLNDPELIKKVCVKDFDHFPNHQ-----PFITSN 111
            |.          |..|....|.        |.:.||:.:|.:..:. |...:|.     |:|...
  Rat    77 TR----------VKNFPSACPQWLWGSNVRIQVYDPDYMKLILGRS-DPKSHHSYRFLAPWIGYG 130

  Fly   112 DRLFNDMLSVMRDQRWKHMRNTLTPVFTAAKMRNMFTLM----------------NESFAECLQH 160
                   |.::..|.|...|..|||.|....::....:|                .:|..|..||
  Rat   131 -------LLLLNGQTWFQHRRMLTPAFHYDTLKPYVGIMADSVRIMLDKWEQIVGQDSTLEIFQH 188

  Fly   161 -----LDSSSKTLPGRKG-FEVDMKVMCN-KLSNDIIATTAFGLKVNSYDNPKNEFYEIGQSLVF 218
                 ||:..|....::| .::|.|.... |...|:...:.|.:        :|.|::  ..:::
  Rat   189 ITLMTLDTIMKCAFSQEGSVQLDRKYKSYIKAVEDLNNLSFFRI--------RNIFHQ--NDIIY 243

  Fly   219 SRGLQFFKFMLSTLVPKLFSLLKLT------IFDSAKVDYFARLVVEAMQYREKHNITRPDMIQL 277
            |         ||:...|..|..:|.      :..|.|    |:|..|....:.|.. .|.|.:.:
  Rat   244 S---------LSSNGRKARSAWQLAHEHTDQVIKSRK----AQLQDEEELQKVKQK-RRLDFLDI 294

  Fly   278 LMEAKNESEDKWTDDEIVAQCFIFFFAAFENNSNLICTTTYELLYNPDVQERLYEEIVETKKAL- 341
            |:.|:.|:....:|.::.|:...|.|...:..::.|....|.|..||:.|:...:||    ::|
  Rat   295 LLFARIENGSSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQGCRKEI----QSLL 355

  Fly   342 -NGAPLTYDAVQKMTYMDMVISESLRKWTLAAATDRLCSKDYTLTDDDGTKLFDFKVGDRINIPI 405
             :||.:|:|.:.||.|..|.|.|:||.:....|..|:.|...|.  .||..|   ..|..:.:..
  Rat   356 GDGASITWDDLDKMPYTTMCIKEALRIYPPVTAVSRMLSTPVTF--PDGRSL---PKGITVMLSF 415

  Fly   406 SGLHLDDRYFPEPRKFDPDRFSEERKGDMVPYTYLPFGVGPRNCIGNRYALMQVKGMLFNLLLHY 470
            .|||.:...:|.|..|||.||:.|  .....:::|||..|.|||||.::|:.::|..:...||.:
  Rat   416 YGLHHNPTVWPNPEVFDPYRFAPE--SSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRF 478

  Fly   471 KIEASPRTI 479
            ::...|..|
  Rat   479 ELLPDPTRI 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	118/490 (24%)
Cyp4a8	XP_038965258.1	CYP4B-like	72..505	CDD:410771	115/469 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900