DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9b2 and Tbxas1

DIOPT Version :9

Sequence 1:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_036819.1	Gene:	Tbxas1 / 24886	RGDID:	3826	Length:	533	Species:	Rattus norvegicus

Alignment Length:	563	Identity:	156/563 - (27%)
Similarity:	259/563 - (46%)	Gaps:	105/563 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LIEICLALVVIGYLIYKW-STATFKTFEERKLYFEKPYPFVGNMAAAALQKSSFQRQLTEFYE-- 64
            ::.:.|::|::..|  || ||:.|....:..:...:|.|||||:        .|.||  .|:|
  Rat    15 VVTVTLSVVLLALL--KWYSTSAFSRLRKLGIRHPEPSPFVGNL--------MFFRQ--GFWESH 67

  Fly    65 ---RTRQHKLVGFFNMRTPMITLNDPELIKKVCVKDFDHFPNH-----QPFITSNDRLFNDMLSV 121
               |.|...|.|::..|...|.::||::||:|.|::|.:|.|.     :|      :|..|.:.:
  Rat    68 LELRERYGPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGLEP------KLIADSVLM 126

  Fly   122 MRDQRWKHMRNTLTPVFTAAKMRNMFTLMNESFAECLQHLDSSSKTLPGRKGFEVDMKVMCNKLS 186
            :||:||:.:|..|...|:..|:..|..|::::....|.||..|:.:   ...|::.....|  .:
  Rat   127 LRDRRWEEVRGALMSAFSPEKLNEMTPLISQACELLLSHLKHSAAS---GDAFDIQRCYCC--FT 186

  Fly   187 NDIIATTAFGLKVNSYDNPKNEFYEIGQSLVFSRGLQFFKFMLSTLVPKLFSLLKLTIFDSAKV- 250
            .:::|:.|||::|||.|.|::.|.:..|.:          |..||..|.|..:|.   |.|..|
  Rat   187 TNVVASVAFGIEVNSQDAPEDPFVQHCQRV----------FAFSTPRPLLALILS---FPSIMVP 238

  Fly   251 --------------DYFARLVVEAMQYREKHNI--TRPDMIQLLMEAKN-------ESEDKWTD- 291
                          .:|..|:...:..|:|...  .|.|.:|::::|:.       |:.|..|:
  Rat   239 LARILPNKNRDELNGFFNTLIRNVIALRDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMVTEA 303

  Fly   292 -------------------------DEIVAQCFIFFFAAFENNSNLICTTTYELLYNPDVQERLY 331
                                     |||..|.|:|..|..|..:|.:...||.|..:|:.||||.
  Rat   304 LSSAECMGDPPQRCHPTSTAKPLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATHPECQERLL 368

  Fly   332 EEIVETKKALNGAPLTYDAVQKMTYMDMVISESLRKWTLAAATDRLCSKDYTLTDDDGTKLFDFK 396
            :| |:.....:.||...:..:.:.|:|||::|:||.:..|....|..::|..:...      ...
  Rat   369 KE-VDLFMEKHPAPEYCNLQEGLPYLDMVVAETLRMYPPAFRFTREAAQDCEVLGQ------HIP 426

  Fly   397 VGDRINIPISGLHLDDRYFPEPRKFDPDRFSEERKGDMVPYTYLPFGVGPRNCIGNRYALMQVKG 461
            .|..:.|.:..||.|..::|.|..|||:||:.|.:....|:||||||.|||:|:|.|..|:.||.
  Rat   427 AGSVLEIAVGALHHDPEHWPNPETFDPERFTAEARLQQKPFTYLPFGAGPRSCLGVRLGLLVVKL 491

  Fly   462 MLFNLLLHYKIEASPRTIKDLWGSASGFNFTPRSGFWMHLVPR 504
            .|..:|..::.||.|.|...| ...|.....|::|.::.:|.|
  Rat   492 TLLQVLHKFRFEACPETQVPL-QLESKSALCPKNGVYVKIVSR 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	141/500 (28%)
Tbxas1	NP_036819.1	p450	47..530	CDD:278495	146/524 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm9060
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.770