DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9b2 and cyp-25A2

DIOPT Version :9

Sequence 1:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_497776.2	Gene:	cyp-25A2 / 175495	WormBaseID:	WBGene00007964	Length:	502	Species:	Caenorhabditis elegans

Alignment Length:	529	Identity:	144/529 - (27%)
Similarity:	240/529 - (45%)	Gaps:	58/529 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LIEICLALVVIGYLIYKW--STATFKTFEERKLYFEKPYPFVGNMAAAA--LQKSSFQRQLTEFY 63
            ||...:.::::.::||..  ....||..|:..|...:|:.|:||:....  .:|..:......|.
Worm     4 LILTSILILLVSFIIYILFARREQFKLREKIGLTGPEPHWFMGNLKQIVDRKEKLGYDDSNKWFN 68

  Fly    64 ERTRQH-KLVGFFNMRTPMITLNDPELIKKVCVKDFDHFPNH-QPFITSNDRLFNDMLSVMRDQR 126
            |..:|: :..|.:......|.|::.|.||:|.:|:|.:|.:. .|.|..:::|...:|.......
Worm    69 ELHKQYGETFGIYFGAQMNIVLSNEEDIKEVFIKNFSNFSDRIVPPIFDSNQLNQSLLQNTYATG 133

  Fly   127 WKHMRNTLTPVFTAAKMRNMFTLMN---ESFAECLQHLDSSSKTLPGRKGFEVDMKVMCNKLSND 188
            |||.|:.:.|:|:..||:.|...::   :.|.:.|:...||        |.:.|:......|:.|
Worm   134 WKHTRSAIAPIFSTGKMKAMQETIHSKVDLFLDILREKASS--------GQKWDIYEDFQGLTLD 190

  Fly   189 IIATTAFGLKVNSYDNPKNEFYEIGQSLVFSRGLQFFK-----FMLSTLVPKLFSLLKLTIFDSA 248
            :|...||.:..|...:..:.||...:..:.:..::..|     |:|..|.|...:|.|.|....|
Worm   191 VIGKCAFAIDSNCQRDRNDVFYVNARKFIANIDIRHSKVIAASFILPELAPLWRALYKYTPLADA 255

  Fly   249 KVDYFARLVVEAMQ--YREKHNITRPDMIQLLMEAKNESEDK---WTDDEIVAQCFIFFFAAFEN 308
            ::.     :||.:.  |..:......|.:.||....|..:||   .|..|::..||.|..|.:|.
Worm   256 EIP-----LVEGLSNVYERRRGGEGSDSVDLLKLLLNREDDKSKPMTKQEVIENCFAFLLAGYET 315

  Fly   309 NSNLICTTTYELLYNPDVQERLYEEIVETKKALNGAPLTYDAVQKMTYMDMVISESLRKW-TLAA 372
            .|..:...:|.|...|:||::|||||:|.|:  ||. ||||::..|.|:|.|..|:||.: .:..
Worm   316 TSTAMTYCSYLLSKYPNVQQKLYEEIMEAKE--NGG-LTYDSIHNMKYLDYVYKETLRCYPPVIH 377

  Fly   373 ATDRLCSKDYTLTDDDGTKLFDFKVGDRINIPISGLHLDDRYFPEPRKFDPDRFS--EERKGDMV 435
            ..:|.|..|.|:......|      |..:......:||:...:..|.:|.|:||.  ||:...:
Worm   378 FINRRCLADITIRGQFYPK------GSVVTCLPHTVHLNPENWDSPEEFHPERFENWEEKSSSL- 435

  Fly   436 PYTYLPFGVGPRNCIGNRYALMQVKGMLFNL-----LLHYKIEASPRTIKDLWGSASGFNFTPRS 495
              .::|||||||.|:|.|:|.|:.|..:..|     |..:|.||      ||....:|....|:.
Worm   436 --KWIPFGVGPRYCVGMRFAEMEFKTTIVKLLDTFELKQFKGEA------DLIPDCNGVIMRPKD 492

  Fly   496 GFWMHLVPR 504
            ...:.|.||
Worm   493 PVRLLLKPR 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	129/465 (28%)
cyp-25A2	NP_497776.2	p450	38..498	CDD:278495	133/490 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166588
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28638
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm4722
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	O	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.760