DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9b2 and CYP7A1

DIOPT Version :9

Sequence 1:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_000771.2	Gene:	CYP7A1 / 1581	HGNCID:	2651	Length:	504	Species:	Homo sapiens

Alignment Length:	513	Identity:	115/513 - (22%)
Similarity:	205/513 - (39%)	Gaps:	94/513 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALIEICLALVVIGYLIYKWSTATFKTFEERKLYFEKP-----YPFVGNMAAAALQKSSFQRQLT 60
            :|:...|...:::|.              .|:...|.|     .|::|    .|||..:...:..
Human    10 IAIAACCCLWLILGI--------------RRRQTGEPPLENGLIPYLG----CALQFGANPLEFL 56

  Fly    61 EFYERTRQH----KLVGFFNMRTPMITLNDPELIKKVC-VKDFDHFPNHQPFITSNDRLFNDMLS 120
            ...:|...|    ||:|.:   ...|| |.....|.:| .|.||....|  |.||.....:..:.
Human    57 RANQRKHGHVFTCKLMGKY---VHFIT-NPLSYHKVLCHGKYFDWKKFH--FATSAKAFGHRSID 115

  Fly   121 VMRDQRWKHMRNTLTPVFTAAKMRNMFTLMNESFAECLQHL-----DSSSKT----LPGRKGFEV 176
            .|.....:::.:|    |......:....:.||..|.||.:     .|:|||    ..|...|
Human   116 PMDGNTTENINDT----FIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSF-- 174

  Fly   177 DMKVMCNKLSNDIIATTAFGLKVNSYDNPKNEFYEIGQSLVFSRGLQFFKFMLSTLVPKLFSLLK 241
                 |.::..:....|.||..:...|..|....         ..|..|| ....:.|.|.:.|.
Human   175 -----CYRVMFEAGYLTIFGRDLTRRDTQKAHIL---------NNLDNFK-QFDKVFPALVAGLP 224

  Fly   242 LTIFDSAKVDYFAR-LVVEAMQYREKHNITRPDMIQLLMEAK---NESEDKWTDDEIVAQCFIFF 302
            :.:|.:|   :.|| .:.|::::   .|:.:.:.|..|:..:   |::...:.|.|......:..
Human   225 IHMFRTA---HNAREKLAESLRH---ENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVL 283

  Fly   303 FAAFENNSNLICTTTYELLYNPDVQERLYEEIVET------KKALNGAP--LTYDAVQKMTYMDM 359
            :|:..|.......:.::::.||:..:...||:..|      |.:|.|.|  |:...:..:..:|.
Human   284 WASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDS 348

  Fly   360 VISESLRKWTLAAATDRLCSKDYTLTDDDGTKLFDFKVGDRINIPISGLHLDDRYFPEPRKFDPD 424
            :|.|||| .:.|:...|...:|:||..:||:  ::.:..|.|.:....:|||...:|:|..|..|
Human   349 IIKESLR-LSSASLNIRTAKEDFTLHLEDGS--YNIRKDDIIALYPQLMHLDPEIYPDPLTFKYD 410

  Fly   425 RFSEER---------KGDMVPYTYLPFGVGPRNCIGNRYALMQVKGMLFNLLLHYKIE 473
            |:.:|.         .|..:.|.|:|||.|...|.|..:|:.::|..|..:|.::::|
Human   411 RYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELE 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	110/477 (23%)
CYP7A1	NP_000771.2	p450	32..497	CDD:365848	110/477 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5364
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860