DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9b2 and CYP3A4

DIOPT Version :9

Sequence 1:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_059488.2	Gene:	CYP3A4 / 1576	HGNCID:	2637	Length:	503	Species:	Homo sapiens

Alignment Length:	499	Identity:	161/499 - (32%)
Similarity:	265/499 - (53%)	Gaps:	49/499 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALI-----EICLALVVIGYLIYKWSTATFKTFEERKLYFEKPYPFVGNMAAAALQKSSFQRQLT 60
            ||||     |..|.|.|...|:|.:.|.:...|::..:....|.||:||:.:.......|..:..
Human     1 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECH 65

  Fly    61 EFYERTRQHKLVGFFNMRTPMITLNDPELIKKVCVKD-FDHFPNHQPFITSNDRLFNDMLSVMRD 124
            :.|     .|:.||::.:.|::.:.||::||.|.||: :..|.|.:||  .........:|:..|
Human    66 KKY-----GKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPF--GPVGFMKSAISIAED 123

  Fly   125 QRWKHMRNTLTPVFTAAKMRNMFTLMNESFAECLQHLDSSSKTLPGRKGFEVDMKVMCNKLSNDI 189
            :.||.:|:.|:|.||:.|::.|..::.:.....:::|...::|     |..|.:|.:....|.|:
Human   124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAET-----GKPVTLKDVFGAYSMDV 183

  Fly   190 IATTAFGLKVNSYDNPKNEFYEIGQSLV-------FSRGLQFFKFMLSTLVPKLFSLLKLTIFDS 247
            |.:|:||:.::|.:||::.|.|..:.|:       |...:..|.|    |:| :..:|.:.:|..
Human   184 ITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPF----LIP-ILEVLNICVFPR 243

  Fly   248 AKVDYFARLVVEAMQYR----EKHNITRPDMIQLLMEAKN----ESEDKWTDDEIVAQCFIFFFA 304
            ...::..:.|....:.|    :||   |.|.:||:::::|    ||....:|.|:|||..||.||
Human   244 EVTNFLRKSVKRMKESRLEDTQKH---RVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA 305

  Fly   305 AFENNSNLICTTTYELLYNPDVQERLYEEIVETKKALNGAPLTYDAVQKMTYMDMVISESLRKWT 369
            .:|..|:::....|||..:||||::|.|||.....  |.||.|||.|.:|.|:|||::|:||.:.
Human   306 GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLP--NKAPPTYDTVLQMEYLDMVVNETLRLFP 368

  Fly   370 LAAATDRLCSKDYTLTDDDGTKLFDFKVGDRINIPISGLHLDDRYFPEPRKFDPDRFSEERKGDM 434
            :|...:|:|.||..:..     :|..| |..:.||...||.|.:|:.||.||.|:|||::.|.::
Human   369 IAMRLERVCKKDVEING-----MFIPK-GVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNI 427

  Fly   435 VPYTYLPFGVGPRNCIGNRYALMQVKGMLFNLLLHYKIEASPRT 478
            .||.|.|||.|||||||.|:|||.:|..|..:|.::..:....|
Human   428 DPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKET 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	148/456 (32%)
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	149/461 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1946
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2940
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.870