DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9b2 and Cyp4a10

DIOPT Version :9

Sequence 1:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_034141.3	Gene:	Cyp4a10 / 13117	MGIID:	88611	Length:	509	Species:	Mus musculus

Alignment Length:	558	Identity:	124/558 - (22%)
Similarity:	210/558 - (37%)	Gaps:	133/558 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ALIEICLALV--VIGYLIYKWSTATFKTFEERKLYFEKPYPFVGNMAAAALQKSSFQRQLTEFYE 64
            :::.:.|.||  |..||..:|....|:.|.....::     |.|:      :|....::|.|..
Mouse    23 SVLGLLLLLVKAVQFYLHRQWLLKAFQQFPSPPFHW-----FFGH------EKFKGDQELQEIV- 75

  Fly    65 RTRQHKLVGFFNMRTP--------MITLNDPELIKKVCVKDFDHFPNHQPFITSNDRLFNDM--- 118
                 ..:..|....|        .:|:.||:.:|.:..:.       .|......||....
Mouse    76 -----SCIENFPSAFPRWFWGSKAYLTVYDPDYMKVILGRS-------DPKANGAYRLLAPWIGY 128

  Fly   119 -LSVMRDQRWKHMRNTLTPVF-------TAAKMRNMFTLM---------NESFAECLQHLDSSSK 166
             |.::..|.|...|..|||.|       ....|.:...||         .:|..|..||:  |..
Mouse   129 GLLLLNGQPWFQHRRMLTPAFHYDILKPYVKNMADSIRLMLDKWERLADQDSSIEIFQHI--SLM 191

  Fly   167 TLPGRKGFEVDMKVMCNKLSNDIIATTAFGLK--VNSYDNPKNEFYEIG--QSLVFSRGLQFFKF 227
            ||                   |.:...||..|  |....|.:.....||  .:|..||....|.
Mouse   192 TL-------------------DTVMKCAFSHKGSVQVDGNYRTYLQAIGDLNNLFHSRVRNIFH- 236

  Fly   228 MLSTLVPKLFSLLKLTIFDSAKVDYFARLVVEAMQYREKH----------------------NIT 270
                        ...||:   |:....||..:|.|....|                      ...
Mouse   237 ------------QNDTIY---KLSSNGRLAKQACQLAHDHTDGVIKLRKDQLQDEGELEKIKKKR 286

  Fly   271 RPDMIQLLMEAKNESEDKWTDDEIVAQCFIFFFAAFENNSNLICTTTYELLYNPDVQERLYEEIV 335
            |.|.:.:|:.|:.|:.|..:|.::.|:...|.|...:..::.:....|.|..:||.|:|..||:
Mouse   287 RLDFLDILLFARMENGDSMSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPDHQQRCREEV- 350

  Fly   336 ETKKAL--NGAPLTYDAVQKMTYMDMVISESLRKWTLAAATDRLCSKDYTLTDDDGTKLFDFKVG 398
               ::|  :|:.:|:|.:.::.|..|.|.|:||.:.......|..|.  ::|..||..|   ..|
Mouse   351 ---QSLLGDGSSITWDHLDQIPYTTMCIKEALRLYPPVPGIVRELST--SVTFPDGRSL---PKG 407

  Fly   399 DRINIPISGLHLDDRYFPEPRKFDPDRFSEERKGDMVPYTYLPFGVGPRNCIGNRYALMQVKGML 463
            .::.:.|.|||.:.:.:|.|..|||.||:.:  .....:::|||..|.|||||.::|:.::|.::
Mouse   408 VQVTLSIYGLHHNPKVWPNPEVFDPSRFAPD--SPRHSHSFLPFSGGARNCIGKQFAMSELKVIV 470

  Fly   464 FNLLLHYKIEASPRTIKDLWGSASGFNFTPRSGFWMHL 501
            ...||.:::...|..:.   ...:......::|.::||
Mouse   471 ALTLLRFELLPDPTRVP---MPLARLVLKSKNGIYLHL 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	112/496 (23%)
Cyp4a10	NP_034141.3	p450	52..503	CDD:278495	113/525 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900