DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9b2 and CYP4F8

DIOPT Version :9

Sequence 1:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_009184.1	Gene:	CYP4F8 / 11283	HGNCID:	2648	Length:	520	Species:	Homo sapiens

Alignment Length:	540	Identity:	126/540 - (23%)
Similarity:	221/540 - (40%)	Gaps:	85/540 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LALVVIG--YL---IYKWSTATFKTFEERKLYFEKPYP-----FVGNMAAAALQKSSFQRQLTEF 62
            |.|:|:|  :|   |..|:.|.:......:.:   |.|     |:|::......:... |.||:.
Human    20 LLLLVVGASWLLARILAWTYAFYHNGRRLRCF---PQPRKQNWFLGHLGLVTPTEEGL-RVLTQL 80

  Fly    63 YERTRQHKLVGFFNMRTPMITLNDPELIKKVCVKDFDHFPNHQPFITSNDRLF--------NDML 119
            . .|.....|.:....||:|.|..|::::.|.        |....||..|.:|        .|.|
Human    81 V-ATYPQGFVRWLGPITPIINLCHPDIVRSVI--------NTSDAITDKDIVFYKTLKPWLGDGL 136

  Fly   120 SVMRDQRWKHMRNTLTPVFTAAKMRNMFTLMNESFAECLQHLDSSSKTLPGRKGFEVDMKVMCNK 184
            .:....:|:|.|..|||.|....::....:.::|  ..:.|.......:.|....:|...:  :.
Human   137 LLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKS--ANIMHAKWQRLAMEGSTCLDVFEHI--SL 197

  Fly   185 LSNDIIATTAFGLKVNSYDNPKNEFYEIGQ--SLVFSRGLQFFKF--MLSTLVP--KLFSLLKLT 243
            ::.|.:....|....|..:.|......|.:  :||..|..|||::  .|..|.|  :.|......
Human   198 MTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRACRL 262

  Fly   244 IFD--------------SAKVDYFARLVVEAMQYREKHNITRPDMIQLLMEAKNESEDKWTDDEI 294
            :.|              |..||.|       :|.:.|....  |.|.:|:.:::::..:.:|::|
Human   263 VHDFTDAVIQERRRTLTSQGVDDF-------LQAKAKSKTL--DFIDVLLLSEDKNGKELSDEDI 318

  Fly   295 VAQCFIFFFAAFENNSNLICTTTYELLYNPDVQERLYEEIVETKKALNGAPLTYDAVQKMTYMDM 359
            .|:...|.|...:..::.:....|.|..:|:.|||..:|:.|..|......:.:|.:.::.::.|
Human   319 RAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTM 383

  Fly   360 VISESLRKWTLAAATDRLCSKDYTLTDDDGTKLFDFKV---GDRINIPISGLHLDDRYFPEPRKF 421
            .:.||||.........|.|::|..|.|.        :|   |:..||.|..:|.:...:|:|..:
Human   384 CLKESLRLHPPIPTFARGCTQDVVLPDS--------RVIPKGNVCNINIFAIHHNPSVWPDPEVY 440

  Fly   422 DPDRFSEERKGDMVPYTYLPFGVGPRNCIGNRYALMQVKGMLFNLLLHYKI---EASPRTIKDLW 483
            ||.||..|......|..::||..|||||||.::|:.::|.:|...||.::|   ...||...::.
Human   441 DPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPDHREPRRTPEIV 505

  Fly   484 GSASGFNFTPRSGFWMHLVP 503
            ..|       ..|.|:.:.|
Human   506 LRA-------EDGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	113/479 (24%)
CYP4F8	NP_009184.1	p450	52..504	CDD:306555	114/482 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810