DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9b1 and tbxas1

DIOPT Version :9

Sequence 1:	NP_523645.1	Gene:	Cyp9b1 / 35634	FlyBaseID:	FBgn0015038	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_991172.2	Gene:	tbxas1 / 792041	ZFINID:	ZDB-GENE-030131-8805	Length:	546	Species:	Danio rerio

Alignment Length:	548	Identity:	159/548 - (29%)
Similarity:	261/548 - (47%)	Gaps:	77/548 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ICLVLATIGLLLFKWSTGTFKAFEGRNLYFEKPYPFLGNMAASALQKASFQKQISEFYNRTRHHK 70
            :||.|.::. ||:.:|...|...|...:...||.||:||:   .:.:..|.|..::..|  ::.:
Zfish    22 VCLFLLSLS-LLYWYSISPFSNLERCGIKHPKPLPFIGNL---MMFRNGFFKSQADLIN--KYGR 80

  Fly    71 LVGLFNLRTPMIQINDPQLIKKICVKDFDHFPNHQT---LNIPNERLVNDMLNVMRDQHWRNMRS 132
            :.|.:..|...:.|.||.:::::.||:|:.|||..|   :..|    ::|.|.:::.:.|:.:||
Zfish    81 ICGYYIGRRSTVIIADPDMLRQVMVKEFNKFPNRMTARGITKP----MSDSLIMLKGEQWKRVRS 141

  Fly   133 VLTPVFTSAKMRNMFTLMNESFAQCLEHLKSSQPIAAGENAFELDMKVLCNKLSNDVIATTAFGL 197
            :|||.|::|||:.|..|:|.:....|.:|||.   |..||:|.:.....|  .:.||||:.|||.
Zfish   142 ILTPTFSAAKMKEMVPLINTATETLLRNLKSH---AESENSFNIHKCFGC--FTMDVIASVAFGT 201

  Fly   198 KVNSFDDPENEF-HTIGKTLAFSRGLPFLKFMMC------LLAPKVFNFFKLTIFDSTNVEYFVR 255
            :|:|.::|::.| |...|..|||...|.:.|.|.      |||..:.|..:    |..| .:|.:
Zfish   202 QVDSQNNPDDPFVHQASKFFAFSFFRPIMIFFMAFPFLLRLLAGLLPNKSR----DEMN-SFFTQ 261

  Fly   256 LVVDAMQYRE--KHNITRPDMIQLLMEA------------------------------------K 282
            .:...::.|:  .....|.|.:||:::.                                    :
Zfish   262 CIQKMIKQRDDLSPEQRRKDFLQLMLDVRTNKKFLSVEHFDVVNDADEEAYDGHENSPANESTKR 326

  Fly   283 KESKDNWTDDEIVAQCFIFFFAAFENNSNLICTTAYELLRNLDIQERLYEEVKETQEALKGAPLT 347
            .:.|...|:||||.|.|||..|.:|.:||.:..|.|.|..:.:.|::|.|||.|...  :...:.
Zfish   327 SQQKRMMTEDEIVGQSFIFLVAGYETSSNTLAFTCYLLAVHPECQKKLQEEVDEFFS--RHETVD 389

  Fly   348 YDAAQEMTYMDMVISESLRKWTLSAAADRLCAKDYTLTDDEGTKLFEFKAGDNINIPICGLHWDE 412
            |...||:.|:||||.||||.:..:....|...:|..|......|      |.::.||...||:|.
Zfish   390 YANVQELKYLDMVICESLRLYPPAFRVARDVEEDTVLNGQFLPK------GASLEIPTGFLHYDP 448

  Fly   413 RFFPQPQRFDPERFSERRKKDLIPYTYLPFGVGPRSCIGNRYAVMQAKGMLYNLMLNYKIEASPR 477
            ..:.:|.:|.||||:...|....|:.|||||.|||||:|.|.|.::.|..|.::...:.:.|...
Zfish   449 EHWTEPTKFIPERFTPEAKARRHPFVYLPFGAGPRSCVGMRLAQLEIKVALVHIFRRFNVLACED 513

  Fly   478 TTRDMWESARGFNIIPTTGFWMQLVSRK 505
            |...: |......:.|..|..:::..|:
Zfish   514 TEIPL-ELKSHTTLGPKNGVMVKITERE 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	146/488 (30%)
tbxas1	NP_991172.2	p450	51..536	CDD:278495	150/512 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.720