DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9b1 and Cyp3a25

DIOPT Version :9

Sequence 1:	NP_523645.1	Gene:	Cyp9b1 / 35634	FlyBaseID:	FBgn0015038	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_062766.2	Gene:	Cyp3a25 / 56388	MGIID:	1930638	Length:	503	Species:	Mus musculus

Alignment Length:	494	Identity:	142/494 - (28%)
Similarity:	247/494 - (50%)	Gaps:	50/494 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VEICLVLATIGLLLFKWSTGTFKAFEGRNLYFEKPYPFLGNMAASALQKASFQKQISEFYN---- 64
            :|..::|.|..:|.:.:.|.:...|:...:...||.|.||.              |..:|:
Mouse     9 IETWVLLVTSLVLFYIYGTYSHGLFKKLGIPGPKPLPLLGT--------------IFNYYDGMWK 59

  Fly    65 -----RTRHHKLVGLFNLRTPMIQINDPQLIKKICVKD-FDHFPNHQTLNIPNERLVNDMLNVMR 123
                 ..::.|:.|.:....|::.|.||::||.:.||: :..|.|.:......  .:...:.:..
Mouse    60 FDEDCYKKYGKIWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRRFFGPVG--FMKKAITISE 122

  Fly   124 DQHWRNMRSVLTPVFTSAKMRNMFTLMNESFAQCLEHLKSSQPIAAGENAFELDMKVLCNKLSND 188
            |:.|:.:|::|:|.|||.|::.||.:|.:.....:.:|:..:     |....:.||.:....|.|
Mouse   123 DEEWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREE-----EKGEPISMKDIFGAYSMD 182

  Fly   189 VIATTAFGLKVNSFDDPENEF-HTIGKTLAFSRGLPFLKFMMCLLAP---KVFNFFKLTIFDSTN 249
            ||..|:||:.|:|.::|::.| ....|.|.|....|||  :..:|.|   .::.....:||...:
Mouse   183 VITGTSFGVNVDSLNNPQDPFVQKAKKILKFKIFDPFL--LSIILFPFLTPIYEMLNFSIFPRDS 245

  Fly   250 VEYFVRLVVDAMQYREKHN-ITRPDMIQLLMEAK----KESKDNWTDDEIVAQCFIFFFAAFENN 309
            :.:|.:.|....:.|...| ..|.|.:||:|..:    :||:...:|.|:.||..||.|..::..
Mouse   246 MNFFKKFVKRMKKERLASNQKNRVDFLQLMMNTQNSKGQESQKALSDLEMAAQAVIFIFGGYDAT 310

  Fly   310 SNLICTTAYELLRNLDIQERLYEEVKETQEALKGAPLTYDAAQEMTYMDMVISESLRKWTLSAAA 374
            |..|....|||..:.|:|::|.:|:..|..  ..||:||||..:|.|:|||::||||.:.::...
Mouse   311 STSISLIMYELATHPDVQKKLQDEIDRTLP--NKAPVTYDALMDMEYLDMVVNESLRLYPIAIRL 373

  Fly   375 DRLCAKDYTLTDDEGTKLFEFKAGDNINIPICGLHWDERFFPQPQRFDPERFSERRKKDLIPYTY 439
            :|:..||..:..     :| ...|..:.|||..||.:..::|:||.|.|||||:..|.::.||.|
Mouse   374 ERVSKKDVEING-----VF-IPKGTVVMIPIYPLHRNPEYWPEPQEFCPERFSKENKGNIDPYIY 432

  Fly   440 LPFGVGPRSCIGNRYAVMQAKGMLYNLMLNYKIEASPRT 478
            :|||.|||:|||.|:|::..|..:..::.|:.::....|
Mouse   433 MPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEET 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	135/459 (29%)
Cyp3a25	NP_062766.2	p450	39..493	CDD:278495	136/464 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1928
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	286	1.000	Inparanoid score	I2821
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8813
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.770