DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9b1 and cyp4v7

DIOPT Version :9

Sequence 1:	NP_523645.1	Gene:	Cyp9b1 / 35634	FlyBaseID:	FBgn0015038	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_001073465.1	Gene:	cyp4v7 / 562008	ZFINID:	ZDB-GENE-061103-88	Length:	510	Species:	Danio rerio

Alignment Length:	535	Identity:	122/535 - (22%)
Similarity:	223/535 - (41%)	Gaps:	77/535 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VLATIGLLLFKWSTGTFKAFEGRNLYFEK------------PYPFLGNMAASALQKASFQKQISE 61
            :|.|..|||...||    |:.....|..|            .||.:||..........|..||.|
Zfish    12 ILFTAVLLLLLAST----AYNPLKNYIGKWNEMRPIPGMAGAYPIIGNALQFKTNAGDFFNQIIE 72

  Fly    62 FYNRTRHHKLVGLFNLRTPMIQINDPQLIKKICVKDFDHFPNHQTLNIPNERLVNDMLNVMRDQH 126
            ..|..||..|..::....|.:.:...:.| ::.:.:..|.....:....:..|...:| ....:.
Zfish    73 GTNENRHLPLAKVWVGPVPFLILYHAENI-EVVLSNSRHLDKSYSYRFLHPWLGTGLL-TSTGEK 135

  Fly   127 WRNMRSVLTPVFTSAKMRNMFTLMNES---FAQCLEHLKSSQPIAAGENAFELDMKVLCNKLSND 188
            |||.|.:|||.|..:.:.:...:|||.   ..|.::.|:..:|.    |.|  :...||   :.|
Zfish   136 WRNRRKMLTPTFHFSILSDFLEVMNEQTDILIQKMQKLEDGEPF----NCF--NFITLC---ALD 191

  Fly   189 VIATTAFGLKVNSFDDPENEF----HTIGKTLAFSRGLPFLKFMMCLLAPKVFNFFKLTIFDSTN 249
            :|..||.|.|:.:..:.::|:    :.:...:...:..|:      |....::|..|.....:..
Zfish   192 IICETAMGKKIYAQSNADSEYVQSVYKMSDIITKRQRAPW------LWPDWIYNKLKEGKEHAKR 250

  Fly   250 VEYFVRLVVDAMQYREKHNITRPD------------MIQLLMEAKKESKDNWTDDEIVAQCFIFF 302
            ::.......:.::.|.:...:.||            .:.:|::...|:....:.::|..:...|.
Zfish   251 LKILHSFTANVIRERAEFMSSEPDSDSDQGERKRQAFLDMLLKTTYENGQKLSHEDIQEEVDTFM 315

  Fly   303 FAAFENNSNLICTTAYELLRNLDIQERLYEEVKE---TQEALKGAPLTYDAAQEMTYMDMVISES 364
            |...:..:..:....:.:..:.::|:.:..|::|   :.|...|.    :..:::.|::.||.||
Zfish   316 FEGHDTTAASMNWALHLIGSHPEVQKAVQAELQEVFGSSERHVGV----EDLKKLRYLECVIKES 376

  Fly   365 LRKW-TLSAAADRLCAKDYTLTDDEGTKLFEFKAGDNINIPIC--GLHWDERFFPQPQRFDPERF 426
            ||.: ::...|..:|         |...:..||....:|..|.  .||.|.|:||:|:.|.||||
Zfish   377 LRIFPSVPLFARSIC---------EACHINGFKVPKGVNAVIIPYALHRDPRYFPEPEEFQPERF 432

  Fly   427 SERRKKDLIPYTYLPFGVGPRSCIGNRYAVMQAKGMLYNLMLNYKIEA--SPRTTRDMWESARGF 489
            .....|...||.|:||..|||:|||.|:|:|:.|.:|..::.::.:||  |....|.:.|    .
Zfish   433 MPENSKGRHPYAYIPFSAGPRNCIGQRFAMMEEKVVLATILRHFDVEACQSREELRPLGE----L 493

  Fly   490 NIIPTTGFWMQLVSR 504
            .:.|..|.|::|..|
Zfish   494 ILRPEKGIWIKLQRR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	106/479 (22%)
cyp4v7	NP_001073465.1	p450	44..505	CDD:278495	110/494 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900